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Validaciones de metodologías analíticas de los productos farmacéuticos Naxelan y Sereprid mediante HPLC y espectrofotometría UV-VIS
(Universidad de ChilePrograma Cybertesis, 2006)
Obtención de conjugados de péptidos nanopartículas metálicas con potenciales aplicaciones biomédicas
(Universidad de Chile, 2007)
Uno de los avances de la nanotecnología es la aplicación de nanopartículas
metálicas (NPs) en el campo de la biomedicina. Estas NPs en presencia de campos
magnéticos oscilantes (CMO) pueden absorber energía en forma eficaz y disiparla
localmente...
Mirada actual y proyección a futuro de la farmacia independiente dirigida por un químico farmacéutico frente al oligopolio actual en el mercado chileno
(Universidad de Chile, 2016)
El presente trabajo consideró la implementación y desarrollo de una Farmacia Independiente como un modelo farmacéutico en resurgimiento, y que en los últimos años ha presentado un auge en su crecimiento debido principalmente al actual escenario en...
Obtención de conjugados péptidos-nanopartículas metálicas para el desarrollo de una nueva estrategia terapéutica para la enfermedad de Alzheimer
(Universidad de Chile, 2006)
los agregados tóxicos de A, y a dos de los isómeros de INH para evaluar si el grado de interacción con los agregados de A es secuencia dependiente. Finalmente, se evaluó la estabilidad de los conjugados obtenidos en diferentes condiciones de p...
Preparación de films de complejo polielectrolito quitosano-alginato y comparación de sus propiedades mecánicas y biológicas con films de quitosano
(Universidad de Chile, 2005)
texturas de acuerdo con la Norma Chilena Oficial NCh1151.Of76 y la ASTM D 5458-95 respectivamente. El grado de transmisión de vapor de agua (TVA) fue analizado con el método de la copa húmeda propuesto por la Norma Chilena Oficial NCh2098.Of2000. Las...
Evaluación retrospectiva de las variables asociadas al desarrollo de flebitis en pacientes adultos con nutrición parenteral periférica
(Universidad de ChilePrograma Cybertesis, 2006)
La problemática de la existencia de desnutrición en el paciente hospitalizado es un hecho ya reconocido que abarca al enfermo pre y posquirúrgico. Estos pacientes, en mayor o menor grado, sufren de períodos de ayuno y estrés, lo que conlleva a una...
Modelos de farmacias populares en Chile y Brasil y los resultados en Chile : evaluación de impacto en lo económico, social y sanitario
(Universidad de Chile, 2018)
(modelos) que han surgido en las políticas locales municipales conforme a estos nuevos establecimientos de comercialización y atención farmacéutica nombrados ―Farmacias Populares‖, centrado en las tres dimensiones del acceso a medicamentos propuestos por la...
Year 2015 saw the emergence of the first community pharmacy (―farmacia popular‖) in Chile; it’s a public policy from local government of Recoleta. Since then, this initiative has been replicated up to 145 working pharmacies in effect. One initiative prior to the Chilean experience came up in Brazil after the design of a policy of medicine access, shaping what now is known as the Brazil Community Pharmacy Program (―Programa Farmacia Popular de Brasil‖, PFPB). The goal of this investigation is to provide a integrative look at the different implementation models that have emerged in local government policies according to these new commercialization and pharmaceutical attention places called Community Pharmacies (―Farmacias Populares‖), centered in three dimensions of medicine access proposed by the WHO. This work is a descriptive, non-experimental one with a multicenter approach and a mixed design focusing on three fundamental axis. Mixed design considers a qualitative part with interviews to the Technical Directors of the community pharmacies; and a quantitative part involving price analysis, geographical location and user perception of the Community Pharmacies. A minimum of 10 % of the representative value was considered, by means of an extrapolation (effective sample of 11 %). Most Community Pharmacies are concentrated in Santiago de Chile, and the proportion in other regional areas is almost 1:1 in urban-countryside situation. It has been called to attention the benefit these programs get from supplying mechanisms which privilege demand consolidation in the commune, which is the case of the CENABAST-intermediated purchasing. It has identified that the user population reaches a spending reduction of around 35 % up to 80 % in crucial medicines, thus providing more access. It is also observed a sustained increase of registered users, along with a high index of satisfactory response and acceptability in the user population. Geographically, it cannot be determined whether the Community Pharmacies adds in coverage in a territorial level yet, but does indeed on a population level. Their operative capacity goes beyond any expectation. Finally, every analytical-quantitative and empirical-qualitative result confirm the potential of the Community Pharmacy to position themselves as a real Health Center, to contribute to the Health System and to provide a pharmacy system of high standard...
Year 2015 saw the emergence of the first community pharmacy (―farmacia popular‖) in Chile; it’s a public policy from local government of Recoleta. Since then, this initiative has been replicated up to 145 working pharmacies in effect. One initiative prior to the Chilean experience came up in Brazil after the design of a policy of medicine access, shaping what now is known as the Brazil Community Pharmacy Program (―Programa Farmacia Popular de Brasil‖, PFPB). The goal of this investigation is to provide a integrative look at the different implementation models that have emerged in local government policies according to these new commercialization and pharmaceutical attention places called Community Pharmacies (―Farmacias Populares‖), centered in three dimensions of medicine access proposed by the WHO. This work is a descriptive, non-experimental one with a multicenter approach and a mixed design focusing on three fundamental axis. Mixed design considers a qualitative part with interviews to the Technical Directors of the community pharmacies; and a quantitative part involving price analysis, geographical location and user perception of the Community Pharmacies. A minimum of 10 % of the representative value was considered, by means of an extrapolation (effective sample of 11 %). Most Community Pharmacies are concentrated in Santiago de Chile, and the proportion in other regional areas is almost 1:1 in urban-countryside situation. It has been called to attention the benefit these programs get from supplying mechanisms which privilege demand consolidation in the commune, which is the case of the CENABAST-intermediated purchasing. It has identified that the user population reaches a spending reduction of around 35 % up to 80 % in crucial medicines, thus providing more access. It is also observed a sustained increase of registered users, along with a high index of satisfactory response and acceptability in the user population. Geographically, it cannot be determined whether the Community Pharmacies adds in coverage in a territorial level yet, but does indeed on a population level. Their operative capacity goes beyond any expectation. Finally, every analytical-quantitative and empirical-qualitative result confirm the potential of the Community Pharmacy to position themselves as a real Health Center, to contribute to the Health System and to provide a pharmacy system of high standard...
Redacción de los manuales de organización y procedimientos para el Subdepartamento de Farmacia del Hospital El Carmen Dr. Luis Valentín Ferrada
(Universidad de Chile, 2017)
UNIVERSIDAD DE CHILE
FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS
DEPARTAMENTO DE CIENCIAS QUÍMICAS Y TECNOLOGÍA FARMACÉUTICAS
FARMACIA ASISTENCIAL HOSPITAL EL CARMEN DR. LUIS VALENTÍN FERRADA
REDACCIÓN DE LOS...
MANUALES DE ORGANIZACIÓN Y PROCEDIMIENTOS PARA EL SUBDEPARTAMENTO DE FARMACIA DEL HOSPITAL EL CARMEN DR. LUIS VALENTÍN FERRADA Supervisor de Práctica Prof. María Cristina Melendo Pérez Depto. de Ciencias y Tecnología Farmacéutica Universidad de...
MANUALES DE ORGANIZACIÓN Y PROCEDIMIENTOS PARA EL SUBDEPARTAMENTO DE FARMACIA DEL HOSPITAL EL CARMEN DR. LUIS VALENTÍN FERRADA Supervisor de Práctica Prof. María Cristina Melendo Pérez Depto. de Ciencias y Tecnología Farmacéutica Universidad de...
Síntesis y evaluación farmacológica de nuevos derivados piperazinil benzo[b]tiofenos con potencial afinidad serotoninérgica por el receptor 5-HT1A
(Universidad de Chile, 2008)
tesis, se abordó la síntesis y ensayos farmacológicos exploratorios de nuevos derivados de piperazinil benzo[b]tiofenos como potenciales ligandos del receptor serotoninérgico 5HT1A.
Específicamente, se sintetizaron los derivados (I), (II) y (III), por...
Depression is a common mental disorder consisting in depressed mood with a lack of interest and pleasure in activities of daily living and mainly attributed to a disorder in the serotonergic neurotransmission. The present thesis encompassed the synthesis and pharmacological assays of new piperazinyl benzothiophenes as potential 5-HT1A receptor ligands. The synthesized compounds (I), (II), (III), were obtained by a microwave – assisted Michael addition reaction of piperazine benzothiophenes in the presence of 1- (4,7-dimetho-xybenzo[b]thiophen-2-yl)-2-propen-1-one acting as Michael’s acceptor. Compounds (I-III), were obtained in good yield (75-86%), with short reaction times. The affinity of the new compounds, was evaluated in vitro through radioligand binding assays, carried out in homogenized rat cerebral cortex, using 3[H]-8-OH-DPAT as standard radioligand. The studied compounds showed a moderate affinity I: 32%, II = 14% y III = 39% and 1.6% (IV) against the 92% displacement exhibited for the 8-OHDPAT...
Depression is a common mental disorder consisting in depressed mood with a lack of interest and pleasure in activities of daily living and mainly attributed to a disorder in the serotonergic neurotransmission. The present thesis encompassed the synthesis and pharmacological assays of new piperazinyl benzothiophenes as potential 5-HT1A receptor ligands. The synthesized compounds (I), (II), (III), were obtained by a microwave – assisted Michael addition reaction of piperazine benzothiophenes in the presence of 1- (4,7-dimetho-xybenzo[b]thiophen-2-yl)-2-propen-1-one acting as Michael’s acceptor. Compounds (I-III), were obtained in good yield (75-86%), with short reaction times. The affinity of the new compounds, was evaluated in vitro through radioligand binding assays, carried out in homogenized rat cerebral cortex, using 3[H]-8-OH-DPAT as standard radioligand. The studied compounds showed a moderate affinity I: 32%, II = 14% y III = 39% and 1.6% (IV) against the 92% displacement exhibited for the 8-OHDPAT...