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Seguro de desempleo con cuentas de ahorro óptimo: análisis normativo del sistema chileno
(Universidad de Chile, 2014)
incentivos de las cuentas de ahorro son efectivos . Se obtiene que los beneficios en el desempleo deberían disminuir en el período de desempleo. Pero, si la rentabilidad de los ahorros individuales es baja, el esquema óptimo es similar al tradicional (UI...
Igual como marcador discursivo en el habla de Santiago de Chile: función pragmáticodiscursiva y estratificación social de su empleo
(Universidad de Chile, 2004)
En este artículo se analizan la función pragmática y la estratificación sociolingüística del uso de la partícula igual como marcador del discurso en el habla coloquial de Santiago de Chile. Por un lado, se estudia la función que dicha partícula...
Requerimiento de Slit en la morfogénesis del lóbulo óptico de Drosophila melanogaster
(Universidad de Chile, 2017)
La vía de señalización Slit/Robo es una vía conservada en muchas especies que está involucrada en la guía de axones y dendritas durante el desarrollo del SNC. Estudios previos han demostrado que esta vía cumple un rol importante en la formación y...
The Slit/Robo pathway is a widely conserved across species. It is involved in axon guidance during the development of the Central Nervous System (CNS). Previous studies have demonstrated the importance of this pathway in the formation and maintenance of boundaries in the optic lobe during early developmental stages in Drosophila melanogaster. During this thesis we focused on the characterization of the ligand of this pathway, the Slit protein, which is secreted to the extracellular medium and proteolytically processed. We observed that Slit is important in the establishment of boundaries in the optic lobe during the entire development of the animal. Through rescue experiments using the Gal4/UAS system, we evaluated the role of Slit in different optic lobe subpopulations where is expressed: glia, medulla neurons and photoreceptors. Thereby, we found out that the main source of Slit expression are medulla neurons, even though previous studies suggested that Slit is secreted by glial cells. Then, we assessed if the role of Slit is performed at short-range. For this aim we performed rescue experiments in medulla neurons using a Slit construct bound to a transmembrane domain to keep it attached to the plasma membrane. We observed that this construct did not rescue the mutant phenotype when expressed in medulla neurons. Finally, we performed rescue experiments using a Slit construct that cannot be processed because it lacks the cleavage site, and found that the proteolytic cleavage is not necessary in this cellular context. In summary, we found that during the development of the optic lobe, Slit protein is mainly secreted by medulla neurons, acts as a long-range cue and does not require proteolytic processing for its activity...
The Slit/Robo pathway is a widely conserved across species. It is involved in axon guidance during the development of the Central Nervous System (CNS). Previous studies have demonstrated the importance of this pathway in the formation and maintenance of boundaries in the optic lobe during early developmental stages in Drosophila melanogaster. During this thesis we focused on the characterization of the ligand of this pathway, the Slit protein, which is secreted to the extracellular medium and proteolytically processed. We observed that Slit is important in the establishment of boundaries in the optic lobe during the entire development of the animal. Through rescue experiments using the Gal4/UAS system, we evaluated the role of Slit in different optic lobe subpopulations where is expressed: glia, medulla neurons and photoreceptors. Thereby, we found out that the main source of Slit expression are medulla neurons, even though previous studies suggested that Slit is secreted by glial cells. Then, we assessed if the role of Slit is performed at short-range. For this aim we performed rescue experiments in medulla neurons using a Slit construct bound to a transmembrane domain to keep it attached to the plasma membrane. We observed that this construct did not rescue the mutant phenotype when expressed in medulla neurons. Finally, we performed rescue experiments using a Slit construct that cannot be processed because it lacks the cleavage site, and found that the proteolytic cleavage is not necessary in this cellular context. In summary, we found that during the development of the optic lobe, Slit protein is mainly secreted by medulla neurons, acts as a long-range cue and does not require proteolytic processing for its activity...
La experiencia de los estudiantes del programa talento e inclusión UC en carreras de la Facultad de Medicina
(Universidad de Chile, 2016)
El presente estudio se centra en la implementación de programas de inclusión dentro de la educación superior. Específicamente, en el Programa Talento e Inclusión desarrollado por la Pontificia Universidad Católica de Chile, creado con el propósito...
This research focuses on the implementation of inclusion programs in higher education. Specifically, in the Programa Talento e Inclusión developed by Pontificia Universidad Católica de Chile, created to incorporate outstanding students from disadvantaged backgrounds. The aim of the study is to understand the personal, academic and social experiences of the first year of university life for students in the Programa Talento e Inclusión UC of the Faculty of Medicine. The methodology is based on a qualitative approach through case studies. The study population corresponds to the students of the careers of the Faculty of Medicine admitted through the Programa Talento e Inclusión in admissions from 2014 to 2015. The information was collected through document analysis and group interview. Across content analysis, units of meaning were determine and a categorization system that complies with the principles of Rodríguez, Gil & García (1996) was built. The results show that the experience of university life in first year was fraught with tension. Regarding personal lives of the students, it seems they found difficulties out of relocation, like separation from their families and support networks; as well as time constraints and transportation problems. Academically, students fail to meet the high standards despite the constant effort, getting generally poor academic performance. They are conflicted by the deficit of knowledge in the basic science and study strategies and methods. This generated a state of frustration and listlessness. The social experience proved to be highly valued by students. Prior to entering classes they felt insecurity and prejudice, but then the majority felt welcomed. In some cases they felt excluded due to socioeconomic differences. Another difficulty is preforming peer group coming from close circles. Overall, the experience is enhanced by personal elements such as motivation, effort and perseverance of students. Also for institutional support, mainly summer camp, academic support program, academic leveling and welcoming ceremonies....
This research focuses on the implementation of inclusion programs in higher education. Specifically, in the Programa Talento e Inclusión developed by Pontificia Universidad Católica de Chile, created to incorporate outstanding students from disadvantaged backgrounds. The aim of the study is to understand the personal, academic and social experiences of the first year of university life for students in the Programa Talento e Inclusión UC of the Faculty of Medicine. The methodology is based on a qualitative approach through case studies. The study population corresponds to the students of the careers of the Faculty of Medicine admitted through the Programa Talento e Inclusión in admissions from 2014 to 2015. The information was collected through document analysis and group interview. Across content analysis, units of meaning were determine and a categorization system that complies with the principles of Rodríguez, Gil & García (1996) was built. The results show that the experience of university life in first year was fraught with tension. Regarding personal lives of the students, it seems they found difficulties out of relocation, like separation from their families and support networks; as well as time constraints and transportation problems. Academically, students fail to meet the high standards despite the constant effort, getting generally poor academic performance. They are conflicted by the deficit of knowledge in the basic science and study strategies and methods. This generated a state of frustration and listlessness. The social experience proved to be highly valued by students. Prior to entering classes they felt insecurity and prejudice, but then the majority felt welcomed. In some cases they felt excluded due to socioeconomic differences. Another difficulty is preforming peer group coming from close circles. Overall, the experience is enhanced by personal elements such as motivation, effort and perseverance of students. Also for institutional support, mainly summer camp, academic support program, academic leveling and welcoming ceremonies....
Modelamiento numérico del comportamiento triaxial verdadero de roca intacta mediante elementos discretos y sus implicancias en el diseño minero
(Universidad de Chile, 2015)
En una serie de problemas de diseño relacionados con la mecánica de rocas tales como: la estabilidad de caserones y pilares, galerías, dilución de vetas, entre otros, se asume que el esfuerzo principal intermedio (σ2) no tiene impacto alguno en el...
Edificio mixto Plaza Chacabuco : el respeto del vacío en la ciudad
(Universidad de Chile, 2019)
oportunidad para el ordenamiento de las ciudades versus
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la dispersión y las grandes demandas de tiempo requeridas
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Pero entonces, ¿Por qué no utilizar una tipología
arquitectónica que mezcle los usos de suelo...
Hutton Nest We Grow - College of E n v i r o n m e n t a l Design UC Arquitectos: Berkeley + Kengo Kuma & Associates V. CIERRE 98 C IE RR E CONCLUSIONES Si bien al momento de entregar la memoria, el proyecto aún está inacabado, y todavía faltas...
Hutton Nest We Grow - College of E n v i r o n m e n t a l Design UC Arquitectos: Berkeley + Kengo Kuma & Associates V. CIERRE 98 C IE RR E CONCLUSIONES Si bien al momento de entregar la memoria, el proyecto aún está inacabado, y todavía faltas...
Enfrentando el desajuste entre la oferta del sistema educacional técnico y la demanda de capital humano en la industria minera
(Universidad de Chile, 2012)
El propósito de este estudio es generar una propuesta de política estratégica entre los actores del Sistema Educacional Técnico Profesional y los de la Industria Minera para enfrentar el desajuste actual y proyectado al año 2020, entre la oferta y...
Quimera : diseño de una pipa de agua en cerámica para los usuarios recreativos de cannabis sativa
(Universidad de Chile, 2019)
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tac he d f ro m the pr od uc t, p hy sic al an d o fte n e mo tio na lly Ke ep a clo ck in a dr aw er , p ro vid ing a old la pto p wi tho ut a d efi ne d p er iod of re pa ym en t. Se pa ra tio n Tim e o f u se r-p ro du ct fin...
Impacto en el diseño empírico de caserones abiertos considerando modelos de esfuerzos en tres dimensiones
(Universidad de Chile, 2019)
El Sublevel Stoping (SLS) es el método de explotación subterráneo ampliamente utilizado por la mediana minería en Chile. Uno de los aspectos claves del SLS es mantener el control de la recuperación y dilución minera, mientras se resguarda la...
Aprovechamiento humano de aves marinas durante el Holoceno medio en el litoral árido del norte de Chile
(Sociedad de Biología de Chile, 2013)
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