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Detección de fatiga mental en tareas atencionales a través de cambio de la temperatura corporal periférica
(Universidad de Chile, 2019)
El fenómeno de fatiga mental impone riesgos y dificultades muy importantes para diversos rubros de la sociedad actual (aviación, industria de maquinaria pesada, conducción vehicular). Es por esto que su detección eficiente adquiere un especial...
The phenomenon of mental fatigue imposes very important risks and difficulties for various sectors of today's society (aviation, heavy machinery industry, vehicular driving). That is why special attention must be paid to its efficient detection. At present, mainly physiological parameters are used for its detection, such as electroencephalographic records, ocular behavior and cardiac monitoring. Although these methods are sensitive, they present limitations for their mass application in activities of daily live, such as the late signaling of indicators of mental fatigue or technical difficulties of implementation (such as the interference caused by automated panels in the registry of encephalography). This is why it is particularly important to study simple, low-cost, minimally invasive methodologies that adapt to the context in which they are used, in order to favor their mass and practical implementation. Recent studies suggest that peripheral body temperature can be an interesting candidate as a marker of mental fatigue that meets these characteristics. This is because it reflects the autonomic variations associated with cognitive processes, allowing prediction of performance for different types of attentional activities, which constitute precisely the most sensitive area to the deleterious effects of mental fatigue. That is why, as a general objective of this study, it was proposed to determine the association between the variation of peripheral body temperature and performance, an operational parameter of mental fatigue, during the execution of different attentional tasks. Specifically, their characteristics are compared as a physiological marker with another already established: long-lasting blinks. For this, an exploratory analysis of the predictive importance of attentional performance of different variables of temperature and flicker was carried out, through the "machine-learning" technique, “random forest”. Subsequently, conditional inference trees were constructed with physiological variables of greater predictive importance, in order to verify this predictive importance for the database used. This methodology allowed us to establish that the variation of peripheral body temperature during the course of tasks has a predictive importance of attentional performance, particularly in terms of response time, which could be verified for the constructed database. In addition, the results support the exclusive use of the temperature record at the index finger (peripheral temperature) as a marker of mental fatigue, since its variation was sufficient to determine the predictive importance of attentional performance and it is not necessary to normalize its records with the temperature of the forehead of the subjects (central edge temperature) Thus, these results support the use of peripheral thermal variation as a physiological marker of mental fatigue. This is expected to contribute to the development of detection systems that can be implemented in various scenarios of daily life, in the long term....
The phenomenon of mental fatigue imposes very important risks and difficulties for various sectors of today's society (aviation, heavy machinery industry, vehicular driving). That is why special attention must be paid to its efficient detection. At present, mainly physiological parameters are used for its detection, such as electroencephalographic records, ocular behavior and cardiac monitoring. Although these methods are sensitive, they present limitations for their mass application in activities of daily live, such as the late signaling of indicators of mental fatigue or technical difficulties of implementation (such as the interference caused by automated panels in the registry of encephalography). This is why it is particularly important to study simple, low-cost, minimally invasive methodologies that adapt to the context in which they are used, in order to favor their mass and practical implementation. Recent studies suggest that peripheral body temperature can be an interesting candidate as a marker of mental fatigue that meets these characteristics. This is because it reflects the autonomic variations associated with cognitive processes, allowing prediction of performance for different types of attentional activities, which constitute precisely the most sensitive area to the deleterious effects of mental fatigue. That is why, as a general objective of this study, it was proposed to determine the association between the variation of peripheral body temperature and performance, an operational parameter of mental fatigue, during the execution of different attentional tasks. Specifically, their characteristics are compared as a physiological marker with another already established: long-lasting blinks. For this, an exploratory analysis of the predictive importance of attentional performance of different variables of temperature and flicker was carried out, through the "machine-learning" technique, “random forest”. Subsequently, conditional inference trees were constructed with physiological variables of greater predictive importance, in order to verify this predictive importance for the database used. This methodology allowed us to establish that the variation of peripheral body temperature during the course of tasks has a predictive importance of attentional performance, particularly in terms of response time, which could be verified for the constructed database. In addition, the results support the exclusive use of the temperature record at the index finger (peripheral temperature) as a marker of mental fatigue, since its variation was sufficient to determine the predictive importance of attentional performance and it is not necessary to normalize its records with the temperature of the forehead of the subjects (central edge temperature) Thus, these results support the use of peripheral thermal variation as a physiological marker of mental fatigue. This is expected to contribute to the development of detection systems that can be implemented in various scenarios of daily life, in the long term....
Desarrollo e implementación de un sistema de control de producción online para Embotelladora Andina S.A.
(Universidad de Chile, 2015)
diez embotelladoras más grandes de Coca-Cola en el mundo. El presente trabajo se enfoca a nivel operativo, dentro de la Gerencia de Operaciones de Planta Renca, Chile, y consistió en diseñar e implementar un sistema de control de producción online, que...
Implementación de servidor EPP para la administración de dominios.cl
(Universidad de Chile, 2019)
En el contexto de la administración de nombres de dominio, existe preocupación por NIC Chile respecto de la robustez y del rendimiento de la plataforma de software actual de su Registro. Se predice un aumento de sus canales de inscripción de nombres...
Plan de negocios para un emprendimiento de un sistema en línea de cobranza y recaudación en Chile
(Universidad de Chile, 2019)
Este trabajo consiste en el diseño de un plan de negocios para un emprendimiento de una plataforma en línea de cobranza y recaudación en Chile, que utiliza la automatización para resolver la problemática transversal que tienen pequeñas y medianas...
Análisis crítico del régimen jurídico de videovigilancia de las fuerzas de orden y seguridad pública
(Universidad de Chile, 2007)
de usos que da la Fuerza Pública a los sistemas de captación de imagen y sonido, distinguiéndose según se trate, de videovigilancia policial con fines preventivos, para la investigación de los delitos y las faltas, el control del cumplimiento de las...
Rediseño del sistema de control y manejo multibodega para Farmoquímica del Pacífico
(Universidad de Chile, 2018)
los problemas definidos en las etapas de entrada de mercadería, almacenamiento, picking, registro de inventario y trazabilidad de los productos en sus 2 bodegas. Además se incluye una propuesta de indicadores logísticos para un correcto control de los...
Sistematización de la captura de parámetros hemodinámicos para pacientes de alto riesgo
(Universidad de Chile, 2020)
pacientes. Estos datos son registrados por los profesionales de la salud, enfermeras, técnicos en enfermería y médicos en el Registro Clínico Electrónico. La información registrada es utilizada para la toma de decisiones clínicas en los tratamientos y...
Sistema de Pago de la Pensión Básica Solidaria
(Universidad de ChileCyberDocs, 2010-01-15)
El trabajo consiste del desarrollo de un sistema para el pago de algunos beneficios otorgados en la Reforma Previsional de la Ley 20.255 del 2008, por el Instituto de Previsión Social, IPS (ex INP). En este proyecto, realizado por la empresa...
Colaboración fluida: formalización, aplicación y validación
(Universidad de Chile, 2021)
para conseguir un trabajo de colaboración provechoso. A partir de estos, formalizamos el concepto de Colaboración Fluida, definido como un sistema de crowdsourcing con tareas divisibles, distribuidas, moderadas y positivas, capaz de (1) fomentar la...
Inclusión de nanopartículas de oro en microgeles para controlar la liberación de curcumina por radiación electromagnética
(Universidad de Chile, 2015)
Uno de los grandes desafíos para mejorar los tratamientos actuales es el desarrollo de sistemas de liberación de fármaco sitio-específico que aumenten la efectividad y reduzcan los efectos adversos de las terapias convencionales. Los microgeles son...
One of the great challenges to improve current treatments is the development of site-specific drug delivery systems that increase effectiveness and reduce side effects of conventional therapies. Microgels are attractive systems for drug delivery because they allow to protect drugs from the external environment improving its stability and modifying their release profile in response to various stimulus. In this research we aim to incorporate gold nanoparticles (AuNPs) in microgels to assess its response to the local heat generation produced by irradiating the AuNPs, promoting the release of another co-incorporated molecule. This way we can obtain spatial and temporaly controled drug release. Alginate microgels were developed and loaded with AuNPs that were linked to the CLPFFD peptide which allows the selective recognition of toxic amyloid protein. We also incroporate the lipofilic drug curcumin encapsulated in oil-core nanocarriers From a pharmaceutical point of view, we have shown that by using automated equipment several variables can be controled in microgels formulations (size, polydispersity and reproducibility), allowing highly stable and applicable to industrial scale systems. In release tests, we observed that upon irradiation (532 nm laser) microgels had a significant and sustained release in presence of AuNPs compared to non-irradiated assays or irradiated without AuNPs. These findings allow us to conclude that microgels loaded whith AuNPs could be a promising tool for spatial and temporally controlled drug release...
One of the great challenges to improve current treatments is the development of site-specific drug delivery systems that increase effectiveness and reduce side effects of conventional therapies. Microgels are attractive systems for drug delivery because they allow to protect drugs from the external environment improving its stability and modifying their release profile in response to various stimulus. In this research we aim to incorporate gold nanoparticles (AuNPs) in microgels to assess its response to the local heat generation produced by irradiating the AuNPs, promoting the release of another co-incorporated molecule. This way we can obtain spatial and temporaly controled drug release. Alginate microgels were developed and loaded with AuNPs that were linked to the CLPFFD peptide which allows the selective recognition of toxic amyloid protein. We also incroporate the lipofilic drug curcumin encapsulated in oil-core nanocarriers From a pharmaceutical point of view, we have shown that by using automated equipment several variables can be controled in microgels formulations (size, polydispersity and reproducibility), allowing highly stable and applicable to industrial scale systems. In release tests, we observed that upon irradiation (532 nm laser) microgels had a significant and sustained release in presence of AuNPs compared to non-irradiated assays or irradiated without AuNPs. These findings allow us to conclude that microgels loaded whith AuNPs could be a promising tool for spatial and temporally controlled drug release...