Browsing by Author "Tapia, Victoria"

Now showing items 1-8 of 8

    • Antioxidant responses of cortex neurons to iron loading 
      Aguirre, Pabla; Mena, Natalia P.; Tapia, Victoria; Rojas, Alejandro; Arredondo Olguín, Miguel Armando; Núñez González, Marco (2006)
      Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione levels. ...
    • Apical distribution of HFE–b2-microglobulin is associated with inhibition of apical iron uptake in intestinal ... 
      Arredondo Olguín, Miguel Armando; Tapia, Victoria; Rojas, Alejandro; Aguirre, Pabla; Reyes, Francisca; Marzolo Canales, María Paz; Núñez González, Marco (SPRINGER, 2005-10-03)
      Mutations in the HFE gene result in hereditary hemochromatosis, a disorder of iron metabolism characterized by increased intestinal iron absorption. Based on the observation that ectopic expression of HFE strongly inhibits ...
    • Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central ... 
      Urrutia, Pamela J.; Aguirre, Pabla; Esparza, Andrés; Tapia, Victoria; Mena, Natalia P.; Arredondo Olguín, Miguel Armando; González Billault, Christian; Núñez González, Marco (2013)
      Inflammation and iron accumulation are present in a variety of neurodegenerative diseases that include Alzheimer’s disease and Parkinson’s disease. The study of the putative association between inflammation and iron ...
    • Iron homeostasis in neuronal cells: a role for IREGI 
      Aguirre, Pabla; Mena, Natalia P.; Tapia, Victoria; Arredondo Olguín, Miguel Armando; Núñez González, Marco (BIOMED CENTRAL LTD, 2005-01-24)
      Background: Iron is necessary for neuronal function but in excess generates neurodegeneration. Although most of the components of the iron homeostasis machinery have been described in neurons, little is known about the ...
    • Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ... 
      Núñez González, Marco; Tapia, Victoria; Rojas, Alejandro; Aguirre, Pabla; Gómez, Francisco; Nualart, Francisco (2010)
      00168.2009.—Intestinal iron absorption comprises the coordinated activity of the influx transporter divalent metal transporter 1 (DMT1) and the efflux transporter ferroportin (FPN). In this work, we studied the movement ...
    • Mathematical modeling of the dynamic storage of iron in ferritin 
      Salgado, J. Cristián; Olivera Nappa, Álvaro; Gerdtzen Hakim, Ziomara; Tapia, Victoria; Theil, Elizabeth C.; Conca Rosende, Carlos; Núñez González, Marco (BIOMED CENTRAL LTD, 2010-11-03)
      Background: Iron is essential for the maintenance of basic cellular processes. In the regulation of its cellular levels, ferritin acts as the main intracellular iron storage protein. In this work we present a mathematical ...
    • Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells 
      Núñez González, Marco; Gallardo, Vivian; Muñoz, Patricia; Tapia, Victoria; Esparza, Andrés; Salazar, Julio; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2004-10-01)
      Glutathione (GSH) constitutes the single most important antioxidant in neurons, whereas iron causes oxidative stress that leads to cell damage and death. Although GSH and iron produce opposite effects on redox cell status, ...
    • Upregulation of gamma-glutamate-cysteine ligase as part of the long-term adaptation process to iron ... 
      Aguirre, Pabla; Valdés, Pamela; Aracena Parks, Paula; Tapia, Victoria; Núñez González, Marco (2007)
      Reactive iron is an important prooxidant factor, whereas GSH is a crucial component of a long-term adaptive system that allows cells to function during extended periods of high oxidative stress. In this work, the adaptive ...