Browsing by Author "Olea Azar, Claudio"
Now showing items 81-100 of 106
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Folch Cano, Christian; Guerrero, Juan; Speisky Cosoy, Hernán; Jullian Matthaei, Carolina; Olea Azar, Claudio (Springer, 2013)The present study is focused on the characterization of the interaction between (-)-epigallocatechingallate (EGCG) and cyclodextrins like b-cyclodextrin (bCD), heptakis(2,6 di-O-methyl)-b-cyclodextrin (DMbCD), ...
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Folch Cano, Christian; Guerrero, Juan; Speisky Cosoy, Hernán; Jullian Matthaei, Carolina; Olea Azar, Claudio (2014)The present study is focused on the characterization of the interaction between (-)-epigallocatechingallate (EGCG) and cyclodextrins like β-cyclodextrin (βCD), heptakis(2,6 di-O-methyl)-β-cyclodextrin (DMβCD), and ...
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Acuña Rougier, C.; Mera-Adasme,; Jullian,; Olea Azar, Claudio (2010)The complexes formed by (±)-4′-hydroxyflavanone (OHFL) and heptakis-(2,6-O-dimethyl)-β-cyclodextrin (DM-β-CD) were obtained using the racemic mixture of OHFL. These complexes were able to be studied due to their ...
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Acuña Rougier, C.; Jullian,; Olea Azar, Claudio (2012)Complexes formed by (±)-4′-hydroxyflavanone (OHFL) and the cyclodextrins β-cyclodextrin and (2-hydroxypropyl)-β-CD were obtained using the racemic mixture of the OHFL. These complexes were able to be studied due to their ...
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Fernández, Mariana; Rodríguez Arce, Esteban; Sarniguet, Cynthia; Morais, Tânia S.; Tomaz, Ana Isabel; Olea Azar, Claudio; Figueroa, Roberto; Maya Arango, Juan; Medeiros, Andrea; Comini, Marcelo; Garcia, M. Helena; Otero, Lucía; Gambino, Dinorah (Elsevier, 2015)Searching for new prospective antitrypanosomal agents, three novel Ru(II)-cyclopentadienyl compounds, [Ru(eta(5)-C5H5)(PPh3)L], with HL = bioactive 5-nitrofuryl containing thiosemicarbazones were synthesized and characterized ...
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Physical properties of new ordered bimetallic phases M0.25Cd0.75PS3 (M = Zn-II, Ni-II, Co-II, Mn-II) Fuentealba Castro, Pablo; Olea Azar, Claudio; Aguilar Bolados, H.; Audebrand, N.; Santana, R. C. de; Doerenkamp, C.; Eckert, H.; Magon, C. J.; Spodine Spiridonova, Evgenia (Royal Society of Chemistry, 2020)Four bimetallic phases of the thiophosphate family have been synthesized by the cationic exchange reaction using a freshly prepared K0.5Cd0.75PS3 precursor phase and methanolic solutions of nitrates of the divalent cations ...
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Vieites, Marisol; Otero, Lucía; Santos, Diego; Olea Azar, Claudio; Norambuena, Ester; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Kemmerling Weis, Ulrike; Morello Casté, Antonio; Maya Arango, Juan; Gambino, Dinorah (2009)Eight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated. Most of the complexes showed IC50 values in the ...
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Aravena, María C.; Olea Azar, Claudio; Cerecetto, Hugo; González, Mercedes; Maya Arango, Juan; Rodríguez Becerra, Jorge (2011)Cyclic voltammetry and electron spin resonance techniques were used in the investigation of several potential antiprotozoal containing thiosemicarbazone and carbamate nitrofurans. In the electrochemical behaviour, a ...
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López Alarcón, Camilo; Speisky Cosoy, Hernán; Squella Serrano, Juan; Olea Azar, Claudio; Camargo Grandón, Rodrigo; Núñez Vergara, Luis (KLUWER ACADEMIC/PLENUM PUBL, 2004-10)Purpose. To study the reactivity of C4-substituted 1,4-dihydropyridines (1,4-DHP), with either secondary or tertiary nitrogen in the dihydropyridine ring, toward SIN-1-derived peroxynitrite in aqueous media at pH 7.4. Methods. ...
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Laurie, V. Felipe; Zúñiga, María C.; Carrasco Sánchez, Verónica; Santos, Leonardo S.; Cañete, Álvaro; Olea Azar, Claudio; Ugliano, Maurizio; Agosin Trumper, Eduardo (Elsevier, 2012)Volatile species with thiol functions are important contributors to the flavour of a wide variety of wine types. However, in spite of their importance, their fate during winemaking has not been fully elucidated. In this ...
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Núñez Vergara, Luis; Bollo Dragnic, Soledad; Olea Azar, Claudio; Santander, Paola; Gunckel, Soledad; Squella Serrano, Juan (Sociedad Chilena de Química, 1998)This paper reports the scavenging of the nitro radical anion of nisoldipine by N-acetylcysteine assessed by cyclic volatammetry (CV) and EPR spectroscopic techniques. Studies by CV on the reactivity of the radical were ...
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Aliaga, Margarita E.; López Alarcón, Camilo; Barriga, Germán; Olea Azar, Claudio; Speisky Cosoy, Hernán (2010)Prompted by the recently reported capacity of the physiologically occurring Cu(I)-[glutathione]2 complex (Cu(I)-[GSH)]2) to reduce oxygen, the effect of various GSH-binding metals (Co2+, Cd2+, Zn2+, Pb2+, Al3+, Hg2+ and ...
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Fernández, Luciana A.; Santo, Marisa R.; Reta, Mario; Giacomelli, Liliana; Cattana, Rosa; Silber, Juana J.; Risso, Mariela; Cerecetto, Hugo; González, Mercedes; Olea Azar, Claudio (MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL, 2005-09)The relationship between the herbicidal activity of a number of novel 1,2,5- oxadiazole N-oxides and some physicochemical properties potentially related with this bioactivity, such as polarity, molecular volume, proton ...
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Speisky Cosoy, Hernán; López Alarcón, Camilo; Olea Azar, Claudio; Sandoval-Acua, Cristian; Aliaga, Margarita E. (2011)The physiologically occurring copper-glutathione complex, [Cu(I)-[GSH]2], has the ability to react continually with oxygen, generating superoxide anions (O 2 -). We addressed here the effects that superoxide removal has ...
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Núñez Vergara, Luis; Díaz Araya, Guillermo; Olea Azar, Claudio; Atria Salas, Ana María; Bollo Dragnic, Soledad; Squella Serrano, Juan (1998)Purpose. To determine the formation of the one-electron reduction product from nisoldipine and its reactivity with relevant thiols in mixed medium. Methods. Cyclic voltammetry (CV) and electron paramagnetic resonance (EPR) ...
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Jullian Matthaei, Carolina; Cifuentes, Constanza; Alfaro, Muriel; Miranda, Sebastián; Barriga, Germán; Olea Azar, Claudio (2010)The inclusion complexes of Luteolin (LU) with cyclodextrins (CDs) including β-cyclodextrin (βCD), hydroxypropyl-β-cyclodextrin (HPβCD) and dimethyl-β-cyclodextrin (DMβCD), Scheme 1, have been investigated using the method ...
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Ferrada, Evandro; Arancibia, Verónica; Loeb, Bárbara; Norambuena, Ester; Olea Azar, Claudio; Huidobro Toro, Juan Pablo (ELSEVIER SCIENCE BV, 2007-05)Successful trials with 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, CQ) for Alzheimer’s disease treatment prompted renewed interest in assessing whether its therapeutic action is related to the coordination of ...
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Rodríguez, Jorge; Gerpe, Alejandra; Aguirre, Gabriela; Kemmerling Weis, Ulrike; Piro, Oscar; Arán, Vicente; Maya Arango, Juan; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo (2009)New indazole derivatives have been developed to know about structural requirements for adequate anti-Trypanosoma cruzi activity. In relation to position 1 of indazole ring, we have observed that a butylaminopentyl substituent ...
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Aliaga, Margarita; Carrasco Pozo, Catalina; López Alarcón, Camilo; Olea Azar, Claudio; Speisky Cosoy, Hernán (2011)The intracellularly-occurring Cu(I)-glutathione complex (Cu(I)-[GSH](2)) has the ability to reduce molecular oxygen into superoxide radicals (O-2(center dot-)). Based on such ability, we addressed the potential of this ...
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Pérez Cruz, Karina Angélica; Moncada-Basualto, Mauricio; Morales Valenzuela, Javier; Barriga González, Germán; Navarrete Encina, Patricio; Núñez Vergara, Luis; Squella Serrano, Juan; Olea Azar, Claudio (Elsevier, 2018-05)The antioxidant capacity of hydroxylated coumarins and hydroxybenzoic acids has been widely described. However, there is little information on the antioxidant activity when both systems are functionalized. In this work, ...