Browsing by Author "Benites, Julio"

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    • Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly 
      Gutiérrez, Eunices; Benites, Julio; Valderrama, Jaime; Buc Calderón, Pedro; Verrax, Julien; Nova Martínez, Esteban; Villanelo Lizana, Felipe; Maturana Middleton, Daniel; Escobar, Cristian; Lagos Mónaco, Rosalba; Monasterio Opazo, Octavio (Elsevier, 2015)
      Dihydroxynaphthyl aryl ketones 1e5 have been evaluated for their abilities to inhibit microtubule assembly and the binding to tubulin. Compounds 3, 4 and 5 displayed competitive inhibition against colchicine binding, and ...
    • Studies on quinones. Part 38: Synthesis and leishmanicidal activity of sesquiterpene 1,4-quinones 
      Valderrama, Jaime A.; Benites, Julio; Cortés, Manuel; Pessoa Mahana, Hernán; Prina, Eric; Fournet, Alain (PERGAMON-ELSEVIER SCIENCE LTD, 2003-11-03)
      The reaction of (+)-euryfuran 1 with several benzo-, naphtho- and benzo[b]thiophene-1,4-quinones in acetic acid yields the corresponding euryfuryl-1.4-quinones 3, 5, 7, 8, 10, 12, and 14. The structure of compounds 7, 8, ...