Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

Now showing items 4661-4680 of 5196

    • Pleiotropic effects of atorvastatin in heart failure: Role in oxidative stress, inflammation, endothelial ... 
      Castro, P.; Miranda, Rodrigo; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Alcaíno Olivares, Hernán Alejandro; Chiong Lay, Mario; Bustos Contreras, Carlos Andrés; García Nannig, Lorena; Mellado, Rose Marie; Vukasovic Ramírez, José Luis; Godoy, Iván; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2008-04)
      Background: Increased oxidative stress, a common feature in chronic heart failure, has been associated with inflammation, endothelial dysfunction, and extracellular matrix degradation. Statins have known anti-inflammatory ...
    • Perindopril regulates beta-agonist-induced cardiac apoptosis 
      Gálvez, A. S.; Fiedler Temer, Jenny; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2005-09)
      Administration of the P-adrenergic agonist isoproterenol results in cardiac apoptosis. The effect of short-term P-adrenergic stimulation by isoproterenol on the activity of plasma, lung, and left ventricular (LV) angiotensin ...
    • Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac ... 
      Sánchez Vivar, Raúl; Soto, Cristián; Copaja, Miguel; Mateluna Guajardo, María Francisca; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Letelier Vargas, Alan Gonzalo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2008-08)
      Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type I receptor (AT(1)R), and changes in its expression have been reported in ...
    • A rapid and strong apoptotic process is triggered by hyperosmotic stress in cultured rat cardiac myocytes 
      Gálvez, Anita; Morales, María Paz; Eltit Ortega, José Miguel; Ocaranza, María Paz; Carrasco Alarcón, Loreto del Pilar; Campos Bastidas, Ximena; Sapag Hagar, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (SPRINGER-VERLAG, 2001-05)
      In all cell types, the maintenance of normal cell volume is an essential homeostatic function. Relatively little is known about the induction of apoptosis by hyperosmotic stress and its molecular mechanism in terminally ...
    • Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress ... 
      Castro Agüero, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Padilla, Ivonne; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Lavandero González, Sergio (EDICIONES DOYMA S/L, 2004-11)
      Introduction and objective. Carvedilol is an antioxidant and adrenergic antagonist with demonstrated benefits in terms of mortality from heart failure (HF). The aim of the present study was to evaluate clinical parameters, ...
    • Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth ... 
      Foncea Avila, Rocío; Gálvez, Anita; Pérez Montes, Viviana; Morales, María Paz; Calixto, Andrea; Meléndez Vergara, Jaime; González Jara, Fabián Rodrigo; Díaz Araya, Guillermo; Sapag Hagar, Mario; Sugden, Peter H.; LeRoith, Derek; Lavandero González, Sergio (ACADEMIC PRESS INC, 2000-07-05)
      This study aims to elucidate the signaling pathway for insulin-like growth factor-1 (IGF-1) in cultured neonatal rat cardiomyocytes and particularly the role of IGF-1 in cardiac apoptosis, IGF-1 stimulated polyphosphoinositide ...
    • Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity 
      Hager Ribeiro, Carolina; López Bartolucci, Carolina; Ramírez Toloza, Galia; Valck Calderón, Carolina Eliana; Molina, María Carmen; Aguilar, Lorena; Rodríguez, Margarita; Maldonado, Ismael; Martínez, Ramón; González, Carlos; Troncoso Cotal, Rodrigo; Lavandero González, Sergio; Gingras, Alexandre R.; Schwaeble, Wilhelm; Ferreira, Arturo (PERGAMON-ELSEVIER SCIENCE LTD, 2009-03)
      Trypanosoma cruzi (T cruzi) is the causative agent of Chagas' disease, an endemic and chronic illness that affects 18 million people in Latin America. The mechanisms underlying its pathogenesis are controversial. There is ...
    • Effects of atorvastatin therapy in heart failure: Oxidative stress, inflammation, endothelial dysfunction ... 
      Miranda, Rodrigo; Castro, Pablo; Verdejo, Hugo; Greig, Douglas; Alcaíno Olivares, Hernán Alejandro; Bustos Contreras, Carlos Andrés; Vukasovic Ramírez, José Luis; Godoy, Iván; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2007-03-06)
      Meeting Abstract
    • Persistence of oxidative stress after heart transplantation: A comparative study of patients with heart ... 
      Pérez, Osvaldo; Castro Agüero, Pablo; Díaz Araya, Guillermo; Nettle Nettle, Daniels Maurice; Moraga, Francisco; Chiong Lay, Mario; Jalil Milad, Jorge; Zalaquett Sepúlveda, Ricardo; Morán, Sergio; Becker, Pedro; Corbalán, Ramón; Lavandero González, Sergio (EDICIONES DOYMA S/L, 2002-08)
      Introduction and objective. Chronic heart failure (CHF) is associated with oxidative stress. Heart transplantation, an important therapeutic alternative in these patients, could reduce oxidative stress by improving cardiac ...
    • Subclinical endothelial inflammation markers in a family with type I familial hyperaldosteronism caused by ... 
      Stehr, Carlos B.; Carvajal, Cristián A.; Lacourt, Patricia; Alcaíno Olivares, Hernán Alejandro; Mellado, Rose Marie; Cattani, Andreína; Mosso, Lorena; Lavandero González, Sergio; Fardella, Carlos E. (SOC MEDICA SANTIAGO, 2008-09)
      Background: Type I familial hyperaldosteronism is caused by the presence of a chimaeric gene CYP11B1/CYP11B2 which encodes an enzyme with aldosterone synthetase activity regulated by adernocorticotrophic hormone (ACTH). ...
    • Activity of metalloproteinase-9 is related to oxidative stress in the acute coronary syndrome 
      Bittner, Alex; Castro Agüero, Pablo; Pérez, Osvaldo; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (OXFORD UNIV PRESS, 2006-08)
      Meeting Abstract
    • IGF-1 regulates apoptosis of cardiac myocyte induced by osmotic-stress 
      Morales, María Paz; Gálvez, Anita; Eltit Ortega, José Miguel; Ocaranza, María Paz; Díaz Araya, Guillermo; Lavandero González, Sergio (ACADEMIC PRESS INC, 2000-04-21)
      Insulin-like growth factor-1 (IGF-1) is a natural protectant of cardiac myocytes that has been shown to improve cardiac function. The role of IGF-1 in attenuating apoptosis induced by osmotic stress (sorbitol, SOR) or by ...
    • Rho/Rho kinase signal transduction pathway in cardiovascular disease and cardiovascular remodeling. La ... 
      Jalil Milad, Jorge; Lavandero González, Sergio; Chiong Lay, Mario; Ocaranza, María Paz (EDICIONES DOYMA S/L, 2005-08)
      The small guanosine triphosphatase Rho and its target, Rho kinase, play important roles in both blood pressure regulation and vascular smooth muscle contraction. Rho is activated by agonists of receptors coupled to cell ...
    • Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial ... 
      Ocaranza, María Paz; Díaz Araya, Guillermo; Chiong Lay, Mario; Muñoz, David; Riveros, Juan Pablo; Ebensperger González, Roberto; Sabat, Sebastián; Irarrázabal, Pablo; Jalil Milad, Jorge; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2002-08)
      This study investigated whether long-term administration of isoproterenol (ISO) induces differential expression of angiotensin-converting enzyme (ACE) in lung, plasma, and left ventricle (LV) during development of left ...
    • Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives. ... 
      Miranda, Rodrigo; Castro, Pablo; Verdejo, Hugo; Chiong Lay, Mario; Díaz Araya, Guillermo; Mellado, Rose Marie; Rojas, Diego; Concepción, Roberto; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2007-08)
      Despite advances in treatment, chronic heart failure still is associated with a pool- prognosis and remains a leading cause of cardiovascular death. Cumulatingi evidence sugigest,; that imbalances in redox state lead to a ...
    • Early prevention of experimental left ventricular hypertrophy in experimental hypertension and angiotensin ... 
      Gálvez, Anita; Ocaranza, María Paz; Lavandero González, Sergio; Jalil Milad, Jorge (EDICIONES DOYMA S/L, 2001-11)
      Introduction. Angiotensin II levels can be partially inhibited during chronic administration of angiotensin converting enzyme (ACE) inhibitors, limiting from a clinical point of view its efficacy in the treatment of ...
    • Angiotensin II triggers apoptosis in cardiac fibroblast but not in myofibroblast overexpressing the type 1 receptor 
      Díaz Araya, Guillermo; Vivar Sánchez, Raúl; Soto, C.; Copaja, Miguel; Mateluna, F.; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; Thomas, W. G.; Lavandero González, Sergio (BLACKWELL PUBLISHING, 2007-07)
      Meeting Abstract
    • Carvedilol corrects interventricular and interventricular dyssynchrony in chronic heart failure. 
      Castro, Pablo; Mc-Nab, Pablo; Bittner, Alex; Greig, Douglas; Quintana, Juan Carlos; Chiong Lay, Mario; Díaz Araya, Guillermo; Valenzuela, Rodrigo; Vergara, I.; Corbalán, Ramón; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2005-02-01)
      Meeting Abstract
    • Increased Oxidative Stress Correlates With Pulmonary Vascular Response to Vasodilators in Pulmonary Artery ... 
      Castro Agüero, Pablo; Gabrielli, Luigi; Fasce, Fabrizio; Verdejo, Hugo; Greig, Douglas; Llevaneras, Silvana; Ferrada, Marcela; Hernández, Claudia; Godoy, Iván; García Nannig, Lorena; Mellado, Rose Marie; Sepúlveda, Pablo; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2009-03-10)
      Meeting Abstract
    • The inositol trisphosphate receptor in the control of autophagy 
      Criollo Céspedes, Alfredo; Vicencio, José Miguel; Tasdemir, E.; Maiuri, M. C.; Lavandero González, Sergio; Kroemer, Guido (LANDES BIOSCIENCE, 2007-07)
      The second messenger myo-inositol-1,4,5-trisphosphate (IP3) acts on the IP3 receptor (IP3R), an IP3-activated Ca2+ channel of the endoplasmic reticulum (ER). The IP3R agonist IP3 inhibits starvation-induced autophagy. The ...