Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

Now showing items 901-920 of 5193

    • Associations of six adiposity-related markers with incidence and mortality from 24 cancers—findings from ... 
      Parra Soto, Solange Liliana; Cowley, Emma S.; Rezende, Leandro F. M.; Ferreccio Keadi, Catterina; Mathers, John C.; Pell, Jill P.; Ho, Frederick K.; Celis Morales, Carlos (BMC, 2021)
      Background: Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on ...
    • New quinone antibiotics against methicillin-resistant S. aureus 
      Campanini Salinas, Javier Andrés; Andrades Lagos, Juan Andrés; Hinojosa Torres, Nicolás Antonio; Moreno Ruz, Fabián Eduardo; Alarcón, Pedro; González Rocha, Gerardo; Burbulis, Ian E.; Vásquez Velásquez, David (MDPI, 2021)
      There is an urgent need for the development of new antibiotics. Here, we describe the inhibitory activity of new quinone compounds against methicillin-resistant Staphylococcus aureus (ATCC(R) 43300), methicillin-sensitive ...
    • Toll-like receptor 4 activation prevents rat cardiac fibroblast death induced by simulated ischemia/reperfusion 
      Parra Flores, Pablo Ignacio; Espitia Corredor, Jenaro Antonio; Espinoza Pérez, Claudio Andrés; Queirolo, Cristian; Ayala, Pedro; Brüggendieck, Francisca; Salas Hernández, Aimee; Pardo Jiménez, Viviana Gladys; Díaz Araya, Guillermo Antonio (Frontiers Media, 2021)
      Death of cardiac fibroblasts (CFs) by ischemia/reperfusion (I/R) has major implications for cardiac wound healing. In in vivo models of myocardial infarction, toll-like receptor 4 (TLR4) activation has been reported as ...
    • Thermal behavior improvement of fortified commercial avocado (persea americana Mill.) oil with maqui ... 
      Flores, Marcos; Reyes García, Luis; Ortiz Viedma, Jaime Alejandro; Romero Palacios, Nalda Marcela; Vilcanqui Chura, Yesica Luz; Rogel, Cristian; Echeverría, Javier; Forero Doria, Óscar (MDPI, 2021)
      Avocado oil is considered a highly prized food due to its nutritional contribution. On the other hand, Aristotelia chilensis (Molina) Stuntz (Elaeocarpaceae), common name “maqui”, is an endemic fruit in Chile, well known ...
    • Preliminary investigation of different drying systems to preserve hydroxytyrosol and its derivatives in ... 
      López Salas, Lucía; Cea, Inés; Borrás Linares, Isabel; Emanuelli, Tatiana; Robert Canales, Paz Soledad; Segura Carretero, Antonio; Lozano Sánchez, Jesús (MDPI, 2021)
      Phenolic compounds present in extra virgin olive oil (EVOO) could be retained in its byproducts during processing. Among them, hydroxytyrosol and its derivatives deserve special attention due to their health benefits ...
    • Outbreak: a user‑friendly georeferencing online tool for disease surveillance 
      Arias Carrasco, Raúl Rubén; Giddaluru, Jeevan; Cardozo, Lucas E.; Martins Moraes, Felipe; Maracaja Coutinho, Vinicius; Nakaya, Helder I. (Sociedad de Biología de Chile, 2021)
      The current COVID-19 pandemic has already claimed more than 3.7 million victims and it will cause more deaths in the coming months. Tools that track the number and locations of cases are critical for surveillance and help ...
    • Endoplasmic reticulum-mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells 
      López Crisosto, Camila Paz; Díaz Vegas, Alexis; Castro, Pablo F.; Rothermel, Beverly A.; Bravo Sagua, Roberto Francisco; Lavandero González, Sergio Alejandro (SpringerNature, 2021)
      Subcellular organelles communicate with each other to regulate function and coordinate responses to changing cellular conditions. The physical-functional coupling of the endoplasmic reticulum (ER) with mitochondria allows ...
    • Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy 
      Fernández, Carolina; Torrealba, Natalia; Altamirano, Francisco; Garrido Moreno, Valeria Soraya; Vásquez Trincado, César; Flores Vergara, Raúl Alejandro; López Crisosto, Camila; Ocaranza, María Paz; Chiong Lay, Mario Martin; Pedrozo Cibils, Zully Rocío Evangelina; Lavandero González, Sergio (Public Library Science, 2021)
      Cardiac hypertrophy is the result of responses to various physiological or pathological stimuli. Recently, we showed that polycystin-1 participates in cardiomyocyte hypertrophy elicited by pressure overload and mechanical ...
    • Oligoarginine peptide conjugated to BSA improves cell penetration of gold nanorods and nanoprisms for ... 
      Bolaños, Karen; Sánchez Navarro, Macarena; Tapia Arellano, Andreas; Giralt, Ernest; Kogan, Marcelo Javier; Araya, Eyleen (MDPI, 2021)
      Gold nanoparticles (AuNPs) have been shown to be outstanding tools for drug delivery and biomedical applications, mainly owing to their colloidal stability, surface chemistry, and photothermal properties. The biocompatibility ...
    • Determination of antioxidant activity by Oxygen Radical Absorbance Capacity (ORAC-FL), Cellular Antioxidant ... 
      Pilaquinga, Fernanda; Morey, Jeroni; Fernández, Lenys; Espinoza Montero, Patricio; Moncada Basualto, Mauricio Javier; Pozo Martínez, Josué Santiago; Olea Azar, Claudio Alberto; Bosch, Rafael; Meneses, Lorena; Debut, Alexis; Piña, María de las Nieves (Dove Medical, 2021)
      Purpose: The importance of studying polyphenolic compounds as natural antioxidants has encouraged the search for new methods of analysis that are quick and simple. The synthesis of silver nanoparticles (AgNPs) using plant ...
    • A phenolic-rich extract from ugni molinae berries reduces abnormal protein aggregation in a cellular model ... 
      Pérez Arancibia, Rodrigo Nicolás; Ordóñez, José Luis; Rivas, Alexis; Pihán, Philippe; Sagredo, Alfredo; Ahumada, Ulises; Barriga, Andrés; Seguel, Ivette; Cárdenas, César; Vidal, René L.; Hetz Flores, Claudio Andres; Delporte Vergara, Carla Luz (Public Library Science, 2021)
      Accumulation of misfolded proteins in the brain is a common hallmark of most age-related neurodegenerative diseases. Previous studies from our group identified the presence of anti-inflammatory and antioxidant compounds ...
    • UHPLC-MS chemical fingerprinting and antioxidant, antiproliferative, and enzyme inhibition potential of ... 
      Fernández Galleguillos, Carlos; Quesada Romero, Luisa; Puerta, Adrián; Padrón, José M.; Souza, Ernane; Romero Parra, Javier Hernán; Simirgiotis, Mario J. (MDPI, 2021)
      Gaultheria pumila (Ericaceae) (known as Chaura or Mutilla) is a Chilean native small shrub that produces berry fruits consumed by local Mapuche people. In this study, the chemical fingerprinting and antioxidant, enzyme ...
    • Analysis of carotenoids in haloarchaea species from Atacama saline lakes by high resolution UHPLC-Q-Orbitrap-Mass ... 
      Lizama, Catherine; Romero Parra, Javier Hernán; Andrade, Daniel; Riveros, Felipe; Bórquez, Jorge; Ahmed, Shakeel; Venegas Salas, Luis; Cabalín, Carolina; Simirgiotis, Mario J. (MDPI, 2021)
      Haloarchaea are extreme halophilic microorganisms belonging to the domain Archaea, phylum Euryarchaeota, and are producers of interesting antioxidant carotenoid compounds. In this study, four new strains of Haloarcula sp., ...
    • Nanoparticles as potential novel therapies for urinary tract infections 
      Sánchez, Sofía V.; Navarro Martínez, Nicolás Matías; Catalán Figueroa, Johanna; Morales Montecinos, Javier Octavio (Frontiers Media, 2021)
      Urinary tract infection (UTI) is one of the most common reasons for antibiotic treatment. Nevertheless, uropathogens are steadily becoming resistant to currently available therapies. In this context, nanotechnology emerges ...
    • Study of different chitosan/sodium carboxymethyl cellulose proportions in the development of polyelectrolyte ... 
      Guarnizo Herrero, Víctor; Torrado Salmeron, Carlos; Torres Pabón, Norma; Torrado Durán, Guillermo; Morales, Javier; Torrado-Santiago, Santiago (MDPI, 2021)
      This study investigated the combination of different proportions of cationic chitosan and anionic carboxymethyl cellulose (CMC) for the development of polyelectrolyte complexes to be used as a carrier in a sustained-release ...
    • A brief review on the high-energy electromagnetic radiation-shielding materials based on polymer nanocomposites 
      Acevedo del Castillo, Ángel; Águila Toledo, Ernesto; Maldonado Magnere, Santiago Ignacio; Aguilar Bolados, Héctor Esteban (MDPI, 2021)
      This paper revises the use of polymer nanocomposites to attenuate high-energy electromagnetic radiation (HE-EMR), such as gamma radiation. As known, high-energy radiation produces drastic damage not only in facilities or ...
    • Loss of social/non-social context discrimination by movement acceleration in the valproate model of autism 
      Quezada, Nelva T.; Salas Ortiz, Sebastiana F.; Peralta, Francisco A.; Aguayo Abarca, Felipe Ignacio; Morgado Gallardo, Katherine P.; Mac-Rae, Catherine A.; Fiedler Temer, Jenny Lucy; Aliaga, Esteban E. (Frontiers Media, 2021)
      Autism spectrum disorder (ASD) is a neurodevelopmental alteration characterized by social/communicative deficits, repetitive/stereotyped movements, and restricted/obsessive interests. However, there is not much information ...
    • Deletion of hippocampal glucocorticoid receptors unveils sex-biased microRNA expression and neuronal ... 
      Tejos Bravo, Macarena Verónica Monserrat; Oakley, Robert H.; Whirledge, Shannon D.; Corrales Ibáñez, Wladimir Antonio; Silva, Juan Pablo; García Rojo, Gonzalo Javier; Toledo, Jorge; Sánchez, Wendy; Román Albasini, Luciano Paolo; Aliaga, Esteban; Aguayo Abarca, Felipe Ignacio; Olave Olave, Felipe Antonio; Maracaja Coutinho, Vinicius; Cidlowski b, John A.; Fiedler Temer, Jenny Lucy (Elsevier, 2021)
      Sex differences in the brain have prompted many researchers to investigate the underlying molecular actors, such as the glucocorticoid receptor (GR). This nuclear receptor controls gene expression, including microRNAs ...
    • Development and validation of a multi-locus PCR-HRM method for species identification in mytilus genus with ... 
      Quintrel Curinao, Marianela Verónica; Jilberto, Felipe; Sepúlveda, Matías; Marín Sánchez, María Elisa; Véliz Baeza, David Enrique; Araneda Tolosa, Cristian; Larraín Barth, María Angélica (MDPI, 2021)
      DNA-based methods using informative markers such as single nucleotide polymorphism (SNPs) are suitable for reliable species identification (SI) needed to enforce compliance with seafood labelling regulations (EU No.1379/2013). ...
    • Cooperative binding of ETS2 and NFAT links erk1/2 and calcineurin signaling in the pathogenesis of cardiac ... 
      Luo, Yuxuan; Jiang, Nan; May, Herman I.; Luo, Xiang; Ferdous, Anwerul; Schiattarella, Gabriele G.; Chen, Guihao; Li, Qinfeng; Li, Chao; Rothermel, Beverly A.; Jiang, Dingsheng; Lavandero González, Sergio Alejandro; Gillette, Thomas G.; Hill, Joseph A. (Lippincott Williams & Wilkins, 2021)
      Background: Cardiac hypertrophy is an independent risk factor for heart failure, a leading cause of morbidity and mortality globally. The calcineurin/NFAT (nuclear factor of activated T cells) pathway and the MAPK ...