Now showing items 21-36 of 36

    • Vargas, Pablo; Cortés, Claudio; Vargas, Leonardo; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (ELSEVIER GMBH, 2005-09-02)
      Dendritic cells (DCs) are the only professional antigen-presenting cells endowed with the ability to stimulate naı¨ve T cells and initiate a primary immune response. For this reason, DC-based immunization has been shown ...
    • Elgueta, Raúl; Sepúlveda, Fernando E.; Vilches, Felipe; Vargas, Leonardo; Mora, J. Rodrigo; Bono Merino, María Rosa; Rosemblatt Silber, Mario César (AMER ASSOC IMMUNOLOGISTS, 2008-05-15)
      It has recently been shown that IL-4 can educate dendritic cells (DC) to differentially affect T cell effector activity. In this study, we show that IL-4 can also act upon DC to instruct naive T cells to express the ...
    • Sauma Mahaluf, Daniela; Michea, P.; Lennon Duménil, Ana María; Fierro, A.; Morales, J.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2004)
      Dendritic cells (DCs) generated in vitro from bone marrow precursors using granulocyte-macrophage colony-stimulating factor (GM-CSF) secrete interleukin-2 (IL-2) upon activation, an event probably associated to the ...
    • Naves, Rodrigo; Reyes, Lilian I.; Rosemblatt Silber, Mario César; Jacobelli, Sergio; González, Alfonso; Bono Merino, María Rosa (OXFORD UNIV PRESS, 2006-02)
      Immune surveillance depends on still poorly understood lymphocyte-endothelium interactions required for lymphocyte transendothelial migration into secondary lymphoid organs. The nuclear factor kappa B (NF-kappa B) regulatory ...
    • Rosemblatt Silber, Mario César; Scales, Donald J. (Kluwer Academic Publishers, 1989)
      A microsomal fraction consisting of membranes of transverse tubule origin has been purified by a modification of the calcium-loading procedure initially described by Rosemblatt et al. (J Biol Chem 256:8140-8, 1981). Enzymatic ...
    • Candia, Enzo; Covian, Camila; Rodríguez, Francisco; Wainstein, Nicolás; Morales, Jorge; Rosemblatt Silber, Mario César; Fierro, Alberto (Lippicott Williams & Wilkins, 2015)
    • Faure-André, Gabrielle; Vargas, Pablo; Yuseff, Maria-Isabel; Heuzé, Mélina; Diaz, Jheimmy; Lankar, Danielle; Steri, Veronica; Manry, Jeremy; Hugues, Stéphanie; Vascotto, Fulvia; Boulanger, Jérôme; Raposo, Graça; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Piel, Matthieu; Lennon Duménil, Ana María (AMER ASSOC ADVANCEMENT SCIENCE, 2008-12-12)
      Dendritic cells ( DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We ...
    • Mora, J. Rodrigo; Bono Merino, María Rosa; Manjunath, N.; Weninger, Wolfgang; Cavanagh, Lois L.; Rosemblatt Silber, Mario César; Von Andrian, Ulrich H. (2003)
      Whereas naive T cells migrate only to secondary lymphoid organs1,2, activation by antigen confers to T cells the ability to home to non-lymphoid sites3,4. Activated effector/memory T cells migrate preferentially to ...
    • Vargas, Leonardo; Valdivieso Berríos, Nicolás Alejandro; Tempio, Fabián; Simon Zegers, María Valeska; Sauma Mahaluf, Daniela Macarena; Valenzuela Pérez, Lucía Teresita; Beltrán Muñoz, Caroll Jenny; Castillo Delgado, Loriana Cecilia; Contreras Benavides, Ximena Stella; Acevedo Acevedo, Mónica Loreto; Acevedo, Johanna; González, Rafael I.; Valiente Echeverría, Fernando Andres; Soto Rifo, Ricardo Andrés; Rosemblatt Silber, Mario César; López Nitsche, Mercedes Natalia; Osorio Olivares, Fabiola Beatriz; Bono Merino, María Rosa (BMC, 2022)
      Background Chile was severely affected by COVID19 outbreaks but was also one of the first countries to start a nationwide program to vaccinate against the disease. Furthermore, Chile became one of the fastest countries to ...
    • Nuñez, Sarah; Saez, Juan José; Fernández, Dominique; Flores Santibañez, Felipe; Álvarez, Karla; Tejón, Gabriela; Ruiz, Paulina; Maldonado, Paula; Hidalgo, Yessia; Manriquez, Valeria; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela (Blackwell Publishing, 2013)
      T helper type 17 (Th17) lymphocytes are found in high frequency in tumour-burdened animals and cancer patients. These lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, ...
    • Doñas, Cristian; Neira, Jocelyn; Osorio Barrios, Francisco; Carrasco, Macarena; Fernández, Dominique; Prado, Carolina; Loyola, Alejandra; Pacheco, Rodrigo; Rosemblatt Silber, Mario César (Nature, 2021)
      Dendritic cells (DCs) promote T-cell mediated tolerance to self-antigens and induce inflammation to innocuous-antigens. This dual potential makes DCs fundamental players in inflammatory disorders. Evidence from inflammatory ...
    • Bono Merino, María Rosa; Elgueta, Raúl; Sauma Mahaluf, Daniela; Pino, Karina; Osorio, Fabiola; Michea, Paula; Fierro, Alberto; Rosemblatt Silber, Mario César (2007)
      Knowledge of lymphocyte migration has become a major issue in our understanding of acquired immunity. The selective migration of naive, effector, memory and regulatory T-cells is a multiple step process regulated by a ...
    • Moore, C.; Sauma Mahaluf, Daniela; Morales Peña, José; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Fierro, J. A. (ELSEVIER SCIENCE INC, 2009-07)
      CD4 CD25 Foxp3 regulatory T cells (Treg) mediate immunologic self-tolerance and suppress immune responses. In the gut, a subset of dendritic cells is specialized to induce Treg in a transforming growth factor- (TGF- ...
    • Ruiz, Paulina; Maldonado, Paula; Hidalgo, Yessia; Gleisner, Alejandra; Sauma Mahaluf, Daniela; Silva, Cinthia; Saez, Juan José; Nuñez, Sarah; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (Hindawi, 2013)
      One of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival ...
    • Doñas, Cristian; Fritz, Macarena; Manríquez, Valeria; Tejón, Gabriela; Bono Merino, María Rosa; Loyola, Alejandra; Rosemblatt Silber, Mario César (Hindawi, 2013)
      Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play a crucial role in the maintenance of self-tolerance. They can be generated in the thymus as well as in the periphery through ...
    • Wilhelm, Vivian; Miquel, Alvaro; Burzio, Luis O.; Rosemblatt Silber, Mario César; Engel, Esteban; Valenzuela, Sebastían; Parada, Gustavo; Valenzuela, Pablo D.T. (ELSEVIER SCI LTD., 2006-03-29)
      We report here the protective effect against piscirickettsiosis elicited in fish by a mixture of recombinant proteins. A comparative genomics strategy was used on a genomic library of Piscirickettsia salmonis in order to ...