Browsing by Author "Melo, Francisco"

Now showing items 1-4 of 4

    • Dammarane triterpenes targeting α-synuclein: biological activity and evaluation of binding sites by molecular ... 
      Cornejo, Alberto; Caballero, Julio; Simirgiotis, Mario; Torres, Vanessa; Sánchez, Luisa; Díaz, Nicolás; Guimaraes, Marcela; Hernández, Marcos; Areche Medina, Carlos Alberto; Alfaro, Sergio; Caballero, Leonardo; Melo, Francisco (Taylor & Francis Ltd., 2021)
      Parkinson’s disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes 1, 1a, 1b, and we determined that 1 and 1a inhibit ...
    • Effect of ph on the electrochemical behavior of hydrogen peroxide in the presence of pseudomonas aeruginosa 
      Espinoza Vergara, Javier; Molina, Paulo; Walter, Mariana; Gulppi, Miguel; Vejar, Nelson; Melo, Francisco; Urzúa Acevedo, Marcela del Pilar; Muñoz, Hugo; Zagal, José H.; Zhou, Xiaorong; Azocar, Manuel I.; Páez, Maritza A. (Frontiers Media, 2021)
      The influence of pH on the electrochemical behavior of hydrogen peroxide in the presence of Pseudomonas aeruginosa was investigated using electrochemical techniques. Cyclic and square wave voltammetry were used to monitor ...
    • Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to beta sheet in tau ... 
      Cornejo, Alberto; Aguilar Sandoval, Felipe; Caballero, Leonardo; Machuca, Luis; Muñoz, Patricio; Caballero, Julio; Perry, George; Ardiles, Alejandro; Areche Medina, Carlos; Melo, Francisco (Taylor & Francis, 2017)
      Alzheimer’s disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts targeting amyloid-b plaques have succeeded to remove plaques but failed in clinical trials to improve ...
    • The fumarprotocetraric acid inhibits tau covalently, avoiding cytotoxicity of aggregates in cells 
      González, Camila; Cartagena, Constanza; Caballero, Leonardo; Melo, Francisco; Areche Medina, Carlos Alberto; Cornejo, Alberto (MDPI, 2021)
      Neurodegenerative disorders, including Tauopathies that involve tau protein, base their pathological mechanism on forming proteinaceous aggregates, which has a deleterious effect on cells triggering an inflammatory ...