Browsing by Author "Mena, Natalia P."

Now showing items 1-11 of 11

    • Antioxidant responses of cortex neurons to iron loading 
      Aguirre, Pabla; Mena, Natalia P.; Tapia, Victoria; Rojas, Alejandro; Arredondo Olguín, Miguel Armando; Núñez González, Marco (2006)
      Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione levels. ...
    • Coumarin-Based Fluorescent Probes for Dual Recognition of Copper(II) and Iron(III) Ions and Their Application ... 
      García Beltrán, Olimpo; Cassels Niven, Bruce; Pérez, Claudio; Mena, Natalia P.; Núñez González, Marco; Martínez, Natalia P.; Pizarro Pavez, Paulina Ignacia; Aliaga, Margarita E. (MDPI, 2014)
      Two new coumarin-based “turn-off” fluorescent probes, (E)-3-((3,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS1) and (E)-3-((2,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS2), were synthesized ...
    • Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent ... 
      García Beltrán, Olimpo; Mena, Natalia P.; Yáñez, Osvaldo; Caballero, Julio; Vargas Cortés, Víctor; Núñez González, Marco; Cassels Niven, Bruce (2013)
      A new coumarin-based ‘turn-off’ fluorescent probe, 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl) propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ...
    • Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease 
      Salazar, Julio; Mena, Natalia P.; Hunot, Stephane; Prigent, Annick; Alvarez Fischer, Daniel; Arredondo Olguín, Miguel Armando; Duyckaerts, Charles; Sazdovitch, Veronique; Zhao, Lin; Garrick, Laura M.; Núñez González, Marco; Garrick, Michael D.; Raisman Vozari, Rita; Hirsch, Etienne C. (NATL ACAD SCIENCES, 2008-11-25)
      Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson’s disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells ...
    • Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central ... 
      Urrutia, Pamela J.; Aguirre, Pabla; Esparza, Andrés; Tapia, Victoria; Mena, Natalia P.; Arredondo Olguín, Miguel Armando; González Billault, Christian; Núñez González, Marco (2013)
      Inflammation and iron accumulation are present in a variety of neurodegenerative diseases that include Alzheimer’s disease and Parkinson’s disease. The study of the putative association between inflammation and iron ...
    • Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP plus /MPTP-Lesioned ... 
      Aguirre, Pabla; Mena, Natalia P.; Carrasco, Carlos M.; Muñoz, Yorka; Pérez Henríquez, Patricio; Morales, Rodrigo A.; Cassels Niven, Bruce; Méndez Gálvez, Carolina; García Beltrán, Olimpo; González Billault, Christian; Núñez González, Marco (Public Library Science, 2015)
      Neuronal death in Parkinson's disease (PD) is often preceded by axodendritic tree retraction and loss of neuronal functionality. The presence of non-functional but live neurons opens therapeutic possibilities to recover ...
    • Iron homeostasis in neuronal cells: a role for IREGI 
      Aguirre, Pabla; Mena, Natalia P.; Tapia, Victoria; Arredondo Olguín, Miguel Armando; Núñez González, Marco (BIOMED CENTRAL LTD, 2005-01-24)
      Background: Iron is necessary for neuronal function but in excess generates neurodegeneration. Although most of the components of the iron homeostasis machinery have been described in neurons, little is known about the ...
    • Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders 
      Mena, Natalia P.; Urrutia, Pamela J.; Lourido, Fernanda; Carrasco, Carlos M.; Núñez González, Marco (Elsevier, 2015)
      Synthesis of the iron-containing prosthetic groups—heme and iron–sulfur clusters—occurs in mitochondria. The mitochondrion is also an important producer of reactive oxygen species (ROS), which are derived fromelectrons leaking ...
    • The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against ... 
      Mena, Natalia P.; García Beltrán, Olimpo; Lourido, Fernanda; Urrutia, Pamela J.; Mena, Raúl; Castro Castillo, Vicente; Cassels Niven, Bruce; Núñez González, Marco (Elsevier, 2015)
      Abundant evidence indicates that iron accumulation, oxidative damage and mitochondrial dysfunction are common features of Huntington's disease, Parkinson's disease, Friedreich's ataxia and a group of disorders known as ...
    • Regulation of transepithelial transport of iron by hepcidin 
      Mena, Natalia P.; Esparza, Andrés; Núñez González, Marco (2006)
      Hepcidin (Hepc) is a 25 amino acid cationic peptide with broad antibacterial and antifungal actions. A likely role for Hepc in iron metabolism was suggested by the observation that mice having disruption of the gene encoding ...
    • Regulation of transepithelial transport of iron by hepcidin 
      Mena, Natalia P.; Esparza, Andrés L; Núñez González, Marco (SOCIEDAD BIOLGIA CHILE, 2005-05-24)
      Hepcidin (Hepc) is a 25 amino acid cationic peptide with broad antibacterial and antifungal actions. A likely role for Hepc in iron metabolism was suggested by the observation that mice having disruption of the gene encoding ...