Now showing items 1-14 of 14

    • Paredes Zúñiga, Susana; Trost, Nils; Paz, Javiera F. de la; Alcayaga Urbina, Julio; Allende Connelly, Miguel (Elsevier, 2019)
      Triadimefon (TDF) is a triazole fungicide extensively used in agriculture that has been found as a pollutant in numerous water sources. In mammals, it inhibits monoamine uptake through binding to the dopamine transporter, ...
    • Ortiz Severín, Javiera Rocío; Tandberg, Julia I.; Winther Larsen, Hanne C.; Chávez Espinosa, Francisco; Cambiazo Ayala, Liliana Verónica (MDPI, 2021)
      Piscirickettsia salmonis is the etiologic agent of piscirickettsiosis, a disease that causes significant losses in the salmon farming industry. In order to unveil the pathogenic mechanisms of P. salmonis, appropriate ...
    • Young, Rodrigo M.; Hawkins, Thomas A.; Cavodeassi, Florencia; Stickney, Heather L.; Schwarz, Quenten; Lawrence, Lisa M.; Wierzbicki, Claudia; Cheng, Bowie; Luo, Jingyuan; Ambrosio, Elizabeth Mayela; Klosner, Allison; Sealy, Ian M.; Rowell, Jasmine; Trivedi, Chintan A.; Bianco, Isaac H.; Allende Connelly, Miguel; Busch-Nentwich, Elisabeth M.; Gestri, Gaia; Wilson, Stephen W. (Elife Sciences Publ., 2019)
      The vertebrate eye originates from the eye field, a domain of cells specified by a small number of transcription factors. In this study, we show that Tcf7l1a is one such transcription factor that acts cell-autonomously to ...
    • González, David; Allende Connelly, Miguel (MDPI, 2021)
      Following an injury, axons of both the central nervous system (CNS) and peripheral nervous system (PNS) degenerate through a coordinated and genetically conserved mechanism known as Wallerian degeneration (WD). Unlike ...
    • Rojas Benítez, Diego; Allende Connelly, Miguel L. (MDPI, 2020)
      Transfer RNAs (tRNAs) are the most post-transcriptionally modified RNA species. Some of these modifications, especially the ones located in the anti-codon loop, are required for decoding capabilities of tRNAs. Such is the ...
    • Valenzuela, María José; Caruffo, Mario; Herrera, Yoani; Medina, Daniel A.; Coronado, Maximo; Feijoo, Carmen G.; Muñoz, Salomé; Garrido, Daniel; Troncoso, Miriam; Figueroa, Guillermo; Toro Ibaceta, Magaly Alejandra; Reyes Jara, Angélica; Magne, Fabien; Navarrete, Paola (Frontiers Media, 2018-05-29)
      In this study we evaluated if zebrafish larvae can be colonized by human gut microorganisms. We tested two strategies: (1) through transplantation of a human fecal microbiota and (2) by successively transplanting aerotolerant ...
    • Parada-Kusz, Margarita; Penaranda, Cristina; Hagedorn, Elliott J.; Clatworthy, Anne; Nair, Anil V.; Henninger, Jonathan E.; Ernst, Christoph; Li, Brian; Riquelme, Raquel; Jijon, Humberto; Villablanca, Eduardo J.; Zon, Leonard I.; Hung, Deborah; Allende Connelly, Miguel (Company of Biologists Ltd, 2018)
      © 2018. Published by The Company of Biologists Ltd. Xenografts of the hematopoietic system are extremely useful as disease models and for translational research. Zebrafish xenografts have been widely used to monitor blood ...
    • Castillo, Hozana A.; Cravo, Roberta M.; Azambuja, Ana P.; Simões-Costa, Marcos S.; Sura-Trueba, Sylvia; Gonzalez, Jose; Slonimsky, Esfir; Almeida, Karla; Abreu, José G.; Afonso de Almeida, Marcio A.; Sobreira, Tiago P.; de Oliveira, Saulo H.Pires; de Oliveira, Paulo (Company of Biologists Ltd, 2010)
      Comparative studies of the tetrapod raldh2 (aldh1a2) gene, which encodes a retinoic acid (RA) synthesis enzyme, have led to the identification of a dorsal spinal cord enhancer. Enhancer activity is directed dorsally to the ...
    • Valdivia, Leonardo E.; Young, Rodrigo M.; Hawkins, Thomas A.; Stickney, Heather L.; Cavodeassi, Florencia; Schwarz, Quenten; Pullin, Lisa M.; Villegas, Rosario; Moro, Enrico; Argenton, Francesco; Allende Connelly, Miguel; Wilson, Stephen W. (2011)
      During tissue morphogenesis and differentiation, cells must self-renew while contemporaneously generating daughters that contribute to the growing tissue. How tissues achieve this precise balance between proliferation and ...
    • Sánchez, Mario; Ceci, Maria Laura; Gutiérrez, Daniela; Anguita Salinas, Consuelo; Allende Connelly, Miguel (BioMed Central, 2016)
      Background: Regenerating damaged tissue is a complex process, requiring progenitor cells that must be stimulated to undergo proliferation, differentiation and, often, migratory behaviors and morphological changes. Multiple ...
    • Viscarra, Franco; González Gutiérrez, Juan; Esparza, Erica; Figueroa, Carla; Paillali, Pablo; Hödar Salazar, Martín; Céspedes, Camilo; Quiroz, Gabriel; Sotomayor Zárate, Ramón; Reyes Parada, Miguel; Bermúdez, Isabel; Iturriaga-Vásquez, Patricio (MDPI, 2020)
      Zebrafish is becoming a popular animal model in neuropharmacology and drug discovery, mainly due to its ease of handling and low costs involved in maintenance and experimental work. This animal displays a series of complex ...
    • Guerrero, N.; Meynard, M. M.; Borgonovo, J.; Palma, K.; Concha Nordemann, Miguel; Hetz Flores, Claudio (Bentham Science Publishers B.V., 2017)
      © 2017 Bentham Science Publishers. More than thirty years have passed since the discovery of the prion protein (PrP) and its causative role in transmissible spongiform encephalopathy. Since a combination of both gain- and ...
    • Feijóo, Carmen G.; Oñate, Maritza G.; Milla, Luis A.; Palma, Verónica A. (2011)
      Despite considerable progress, the mechanisms that control neural progenitor differentiation and behavior, as well as their functional integration into adult neural circuitry, are far from being understood. Given the ...
    • Paz Montt, Javiera de la; Beiza Canelo, Natalia; Paredes Zúñiga, Susana; Hoare, Misque S.; Allende Connelly, Miguel (MDPI, 2017-04)
      In animals, hatching represents the transition point from a developing embryo to a free-living individual, the larva. This process is finely regulated by many endogenous and environmental factors and has been shown to be ...