Now showing items 4781-4800 of 4968

    • Allende Connelly, Miguel; Manzanares, Miguel; Tena, Juan J.; Feijóo, Carmen Gloria; Gómez Skarmeta, José Luis (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2006-07)
      Genes involved in vertebrate development are unusually enriched for highly conserved non-coding sequence elements. These regions are readily detected in silico, by genome-wide sequence comparisons between different ...
    • Abin Carriquiry, Juan Andrés; Voutilainen, Merja H.; Barik, Jacques; Cassels Niven, Bruce; Iturriaga-Vásquez, Patricio; Bermúdez, Isabel; Durand, Claudia; Dajas, Federico; Wonnacott, Susan (ELSEVIER, 2006)
      Neuronal nicotinic acetylcholine receptors subserve predominantly modulatory roles in the brain, making them attractive therapeutic targets. Natural products provide key leads in the quest for nicotinic receptor subtype-selective ...
    • Urbina, Daniela C.; Silva Ascencio, Herman; Lee A., Meisel (2006)
      Thapsigargin, a specific inhibitor of most animal intracellular SERCA-type Ca2+ pumps present in the sarcoplasmic/endoplasmic reticulum, was originally isolated from the roots of the Mediterranean plant Thapsia gargancia ...
    • Muñoz, Pablo; Zavala, Gabriela; Castillo, Karen; Aguirre, Pabla; Hidalgo Tapia, María Cecilia; Núñez González, Marco (2006)
      Recent evidence suggests that reactive oxygen species function as second messenger molecules in normal physiological processes. For example, activation of N-Methyl-D-Aspartate receptor results in the production of ROS, ...
    • Mena, Natalia P.; Esparza, Andrés; Núñez González, Marco (2006)
      Hepcidin (Hepc) is a 25 amino acid cationic peptide with broad antibacterial and antifungal actions. A likely role for Hepc in iron metabolism was suggested by the observation that mice having disruption of the gene encoding ...
    • Mazariegos, Dora Inés; Cabantchik, Z. Ioav; Cassels Niven, Bruce; Núñez González, Marco (2006)
      There is increasing evidence that accumulation of redox-active iron in mitochondria leads to oxidative damage and contributes to various neurodegenerative diseases, such as Friedreich’s ataxia and Parkinson’s disease. ...
    • Manríquez Soto, Germán Raúl; González Bergas, Fermín; Salinas, Juan Carlos; Espoueys, Oscar (2006)
      Intentional cranial deformation is a long lasting and worldwide form of permanent modification of the main human head distinctive anatomical attributes. In northern Chile it was extensively done during five thousand years ...
    • Guerrero, Carla; Espinoza, Luis; Niemeyer Marich, August; Simonetti Zambelli, Javier Andrés (2006)
      The distribution and habitat use by carnivores can be assessed by studying their tracks or feces. If these methods are to be used confidently, they should not only unequivocally discriminate among species, but should ...
    • Delgado Arriagada, Ricardo; Vergara Montecinos, Cecilia; Wolff Fernández, José (2006)
      Based on indirect evidence, a role for synaptically released copper and zinc as modulators of neuronal activity has been proposed. To test this proposal directly, we studied the effect of copper, zinc, and other ...
    • Aracena Parks, Paula; Aguirre, Pabla; Muñoz, Pablo; Núñez González, Marco (2006)
      Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that ...
    • Aguirre, Pabla; Mena, Natalia P.; Tapia, Victoria; Rojas, Alejandro; Arredondo Olguín, Miguel Armando; Núñez González, Marco (2006)
      Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione levels. ...
    • Vicencio Poblete, Rodrigo; Flach, Sergej; Molina Gálvez, Mario; Kivshar, Yuri S. (2007)
      We study nonlinear surface modes in two-dimensional anisotropic periodic photonic lattices and demonstrate that, in a sharp contrast to one-dimensional discrete surface solitons, the mode threshold power is lower at the ...
    • Collin, Rachel; Chaparro, Oscar R.; Winkler, Federico; Véliz Baeza, David (2007)
      Evolutionary transitions between different modes of development in marine invertebrates are thought to be biased toward the loss of feeding larvae. Because the morphology of feeding larvae is complex and nonfeeding larvae ...
    • Yarrow, Matthew M.; Marín Briano, Víctor (2007)
      Ecological transition zones are increasingly recognized as systems that play a critical role in controlling or modifying flows of organisms, materials, and energy across landscapes. Many concepts describing transitional ...
    • Ramos Jiliberto, Rodrigo; Garay Narváez, Leslie (2007)
      By means of qualitative techniques we analyze the consequences of inducible defenses of species embedded in trophic chains on the community stability and responses of population equilibrium densities to press perturbations. ...
    • Gomberoff, L. (2007)
      It is shown that in a plasma composed by electrons, a proton core, and a proton beam propagating along an external magnetic field, finite amplitude left-hand polarized waves propagating backward relative to the beam direction ...
    • Campodónico, Paola R.; Andrés, Juan; Aizman, Arie; Contreras Ramos, Renato (2007)
      We propose that a specific property of a chemical fragment, its regional electrophilicity, be taken as defining its nucleofugality index nu(PG) in alpha-elimination reactions. We tabulate this quantity for a series of ...
    • Clerc Gavilán, Marcel; Falcón Beas, Claudio; Escaff, D.; Tirapegui Zurbano, Enrique (2007)
      Interfaces in two-dimensional systems exhibit unexpected complex dynamical behaviors. We present a robust effect of noise in two dimensional extended systems: the motion of a static front connecting a stripe pattern with ...
    • Sanhueza, Magdalena; McIntyre, Charmian C.; Lisman, John E. (2007)
      Long-term potentiation (LTP) is an activity-dependent strengthening of synapses that is thought to underlie memory storage. Ca2+/ calmodulin-dependent protein kinase II (CaMKII) has been a leading candidate as a memory ...
    • Leyton, Patricio; Domingo, C.; Sánchez Cortés, S.; Campos Vallette, Marcelo; Díaz, G. F.; García Ramos, J. V. (2007)
      A vibrational study of the calix[4]arene derivative 25,26,27,28-tetracarboethoxy-p-tert-butylcalix[4]arene (TCEC) is accomplished in this work. This characterization implies a study of its adsorption on metal (Cu and Ag) ...