Now showing items 1933-1952 of 2801

    • Vieites, Marisol; Otero, Lucía; Santos, Diego; Toloza, Jeannette; Figueroa, Roberto; Norambuena, Ester; Olea Azar, Claudio; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Morello Casté, Antonio; Maya Arango, Juan; Garat, Beatriz; Gambino, Dinorah (ELSEVIER SCIENCE INC, 2008-05)
      In the search for new therapeutic tools against Chagas’ disease (American Trypanosomiasis) two series of new platinum(II) complexes with bioactive 5-nitrofuryl containing thiosemicarbazones as ligands were synthesized, ...
    • Vieites, Marisol; Otero, Lucía; Santos, Diego; Olea Azar, Claudio; Norambuena, Ester; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Kemmerling Weis, Ulrike; Morello Casté, Antonio; Maya Arango, Juan; Gambino, Dinorah (2009)
      Eight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated. Most of the complexes showed IC50 values in the ...
    • Castro, P.; Miranda, Rodrigo; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Alcaíno Olivares, Hernán Alejandro; Chiong Lay, Mario; Bustos Contreras, Carlos Andrés; García Nannig, Lorena; Mellado, Rose Marie; Vukasovic Ramírez, José Luis; Godoy, Iván; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2008-04)
      Background: Increased oxidative stress, a common feature in chronic heart failure, has been associated with inflammation, endothelial dysfunction, and extracellular matrix degradation. Statins have known anti-inflammatory ...
    • Squella Serrano, Juan; Benavente, G.; Gallo, B.; Paredes, S.; Núñez Vergara, Luis (1988)
      The enthalpies of the reaction between glutathione and amoxycillin have been measured directly using a flow microcalorimeter. Comparative results are obtained by using an ac polarographic method previously developed in our ...
    • Squella Serrano, Juan; Núñez Vergara, Luis; Rodríguez Bustos, Héctor; Márquez, Amelia; Rodríguez Mellado, J. M.; Blazquez, M.; Roldán, E.; Domínguez, M. (INST ORGANIC CHEM AND BIOCHEM, ACAD SCI CZECH REPUBLIC, 1991-12)
      Five N-p-phenyl substituted benzamidines were studied by DC and DP polarography in a wide pH range. Coulometric results show that the overall processes are four-electron reductions. Logarithmic analysis of the waves indicate ...
    • Núñez Vergara, Luis; Squella Serrano, Juan; Silva, Miranethy (1980)
    • Morales, Alfonso; Toral Ponce, María; Richter Duk, Pablo (1984)
      The polarographic behaviour of nitrofurantoin and chloramphenicol have been studied in pyridine - formic acid buffer and tetramethylammonium chloride solution at pH 4.3. The E<inf>1/2</inf> versus pH and iym ...
    • Richter Duk, Pablo; Toral Ponce, María; Muñoz-Vargas, Fernando (1994)
      A polarographic method for the determination of ranitidine is described, based on the reduction of the nitro group at a dropping-mercury electrode. The proposed method permits the drug to be determined, without any prior ...
    • Carrera, M. Eugenia; Momberg, Astrid; Toral Ponce, María; Richter Duk, Pablo (1991)
      A preconcentration method based on the adsorption on activated carbon of a binary complex of copper(I) with 2,2’-biquinoline, and subsequent polarographic determination of microamounts of copper has been developed. The ...
    • Carrera, M. E.; Momberg, Astrid; Toral Ponce, María; Richter Duk, Pablo (Marcel Dekker, 1991)
      A preconcentration method based on the adsorption on activated carbon of a binary complex of copper(I) with 2,2¡-boquinoline, and subsequent polarographic determination of microamounts of copper has been developed. The ...
    • Squella Serrano, Juan; Sturm,; Diaz, Eloisa; Pessoa,; Núñez Vergara, Luis (Elsevier B.V., 1996)
      Loratadine, a potent antihistamine drug, is not directly electroreducible at a dropping mercury electrode; however, by means of a nitration procedure it is possible to obtain a nitro-loratadine derivative which has been ...
    • Morales, A.; Richter Duk, Pablo; Toral Ponce, María (Royal Society of Chemistry, 1987)
      In pyridine - formic acid buffer and tetramethylammonium chloride solution over the pH range 0-8.5, nitrofurazone, furazolidone and other nitrofuran derivatives are reduced in a six-electron process, giving rise to a well ...
    • Bollo Dragnic, Soledad; Núñez Vergara, Luis; Bontá, M.; Chauviere, G.; Perie, J.; Squella Serrano, Juan (WILEY-V C H VERLAG GMBH, 2001-07)
      Megazol (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazol, CAS 19622-55-0), a highly active compound used against several of Trypanosoma cruzi, the causative agent of Chagas disease, is electrochemically studied ...
    • Squella Serrano, Juan; Muñoz, W.; Núñez Vergara, Luis; Paulos, Claudio (AMER PHARMACEUTICAL ASSN, 1990)
      Nifurtimox is polarographically reducible over the whole pH range, the nitro group being reduced to the hydroxylamine group in a 4ē process and subsequently the amine being formed in a 2ē process at a pH value below 4. The ...
    • Zanocco Loyola, Antonio; Diaz, L.; Lopez, M.; Núñez Vergara, Luis; Squella Serrano, Juan (1992)
      Nimodipine, a calcium antagonist belonging to the dihydropyridine family, produces a well‐defined polarographic peak due to the four‐electron reduction of the nitro group. This peak was used to track the photodecomposition ...
    • Squella Serrano, Juan; Núñez Vergara, Luis (1990)
      The exposure of drugs to light produces photodecomposition processes in several cases: the drugs undergo important chemical changes with a parallel change in their activities or potencies and generally with a loss of their ...
    • Castro Gálvez, Pablo; Greig, Douglas; Copaja, Miguel; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo Hernán; Chiong Lay, Mario; Mellado, Rose Marie; Pérez, Osvaldo; Vukasovic Ramírez, José Luis; Díaz Araya, Guillermo; Corbalán, Ramón; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio (Sociedad Chilena de Cardilología y Cirugía Cardiovascular, 2005)
      Los polimorfismos de los receptores β Adrenérgicos (AR) influencian el grado de actividad del receptor. Los βAR tienen un rol importante en la regulación de la contractilidad y podrían tener implicancias en el riesgo de ...
    • Santa Ana, María Angélica; Benavente Espinosa, Eglantina; Gómez Romero, Pedro; González Moraga, Guillermo (2006)
      The synthesis, characterization and electrochemistry of a novel nanocomposite based on the co-intercalation of lithium and poly(acrylonitrile) (PAN) in molybdenum disulfide [Li0.6MoS2(PAN) 1.2·0.5H2O] is described. The ...
    • Villar, V.; Opazo, A.; Gargallo, L.; Radić, D.; Rios, H.; Clavijo Campos, Ernesto (Taylor and Francis Inc., 1998)
      Interpolymer complex (IC) formation between poly(ethylene-co-maleic acid) and poly(4-vinylpiridine) (P4VPy) has been observed and characterized. Data from viscosity, infrared spectroscopy and thermogravimetric analysis ...
    • Marambio, Oscar G.; Pizarro, Guadalupe del Carmen; Jeria Orell, Manuel; Huerta, Margarita R.; Olea Azar, Claudio; Habicher, W. D. (0887-624X, 2005-10-15)
      The free-radical copolymerization of N-phenylmaleimide (N-PhMI) with acrylic acid was studied in the range of 25-75 mol % in the feed. The interactions of these copolymers with Cu(H) and Co(H) ions were investigated as a ...