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Polarographic study of nifurtimox

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1990
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Squella Serrano, Juan
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Polarographic study of nifurtimox
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Author
  • Squella Serrano, Juan;
  • Muñoz, W.;
  • Núñez Vergara, Luis;
  • Paulos, Claudio;
Abstract
Nifurtimox is polarographically reducible over the whole pH range, the nitro group being reduced to the hydroxylamine group in a 4ē process and subsequently the amine being formed in a 2ē process at a pH value below 4. The C=N-N linkage is reduced by a mechanism involving reductive fission of the N-N bond. The differential pulse polarographic peaks for the reduction of the nitro group to the hydroxylamine group at pH 6 were used in developing a new polarographic method for the determination of nifurtimox in pharmaceutical forms.
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Artículo de publicación ISI.
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URI: https://repositorio.uchile.cl/handle/2250/121220
ISSN: 0022-3549
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JOURNAL OF PHARMACEUTICAL SCIENCES 79 (9): 837-839
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