Now showing items 1211-1230 of 2801

    • Amaral, Paulo P.; Leonardi, Tommaso; Han, Namshik; Vire, Emmanuelle; Gascoigne, Dennis K.; Arias Carrasco, Raúl; Buscher, Magdalena; Pandolfini, Luca; Zhang, Anda; Pluchino, Stefano; Maracaja Coutinho, Vinicius; Nakaya, Helder I.; Hemberg, Martin; Shiekhattar, Ramin; Enright, Anton J.; Kouzarides, Tony (BIOMED Central Ltd., 2018)
      Background: The mammalian genome is transcribed into large numbers of long noncoding RNAs (lncRNAs), but the definition of functional lncRNA groups has proven difficult, partly due to their low sequence conservation and ...
    • López -Escobar, Leopoldo; Frey, Frederick A.; Oyarzún, Jorge (Springer-Verlag, 1979)
      Seventeen granitoid samples from batholiths in central Chile (33 °-34 ° S) have been analyzed for trace element content. The samples range in age from Paleozoic to Tertiary, and in rock type from quartz diorite to granite. ...
    • Rivera, L. A.Patricio; Hernandez, G. Rosario (1996)
      In this work, we report on the isolation and identification of the sesquiterpene 6-Oxo-germacra-1(10)E,4(15)-diene (1). This compound was isolated for the first time from a Chilean Baccharis, B. Sphacrocephala.
    • Piquer Franco, Beatriz Gabriela; Ruz Baltra, Freddy Antonio; Barra Pezo, Rafael Antonio; Lara Peñaloza, Hernán Enrique (MDPI, 2022)
      The exposure to sympathetic stress during the entire period of gestation (4 degrees C/3 h/day) strongly affects the postnatal reproductive performance of the first generation of female offspring and their fertility capacity. ...
    • Arias, Paulina; Ferreyra, Nancy F.; Rivas, Gustavo A.; Bollo Dragnic, Soledad (Elsevier, 2009)
      In this work we report the optimization of a chitosan (CHI) and carbon nanotubes (CNT) modified electrode, CNT-CHI, to study the dsDNA interaction with methylene blue (MB), a well-known DNA intercalator. The analytical ...
    • Jalit, Yamile; Rodríguez, Marcela C.; Rubianes, María D.; Bollo Dragnic, Soledad; Rivas, Gustavo A. (WILEY-V C H VERLAG GMBH, 2008-08)
      We report the analytical performance of glassy carbon electrodes (GCE) modified with a dispersion of multiwall carbon nanotubes (MWCNT) in polylysine (Plys) (GCE/MWCNT-Plys). The resulting electrodes show an excellent ...
    • Troncoso Cotal, Rodrigo; Moraga, Francisco; Chiong Lay, Mario; Roldán S., Juan; Bravo Méndez, Roberto; Valenzuela, Rodrigo; Díaz Araya, Guillermo; Campo Sfeir, Andrea Estefanía del; Sanhueza Muñoz, Carlos Joaquín; Rodríguez Villarroel, Andrea Elizabeth; Vukasovic Ramírez, José Luis; Mellado, Rose Marie; Greig, Douglas; Castro, Pablo; Lavandero González, Sergio (WILEY-BLACKWELL PUBLISHING, 2009-05)
      We investigated the clinical response of chronic heart failure patients with beta(2)- adrenergic receptor Gln(27)-> Glu polymorphism treated for 6 months with carvedilol, a alpha/beta-antagonist with antioxidant properties. ...
    • Alaniz, Alberto J.; Carvajal, Mario A.; Bacigalupo, Antonella; Cattan Ayala, Pedro (Cambridge University Press, 2019)
      Zika virus (ZIKV) is an arbovirus transmitted mainly by Aedes aegypti mosquitoes. Recent scientific evidence on Culex quinquefasciatus has suggested its potential as a vector for ZIKV, which may change the current risk ...
    • Cornejo, Pablo; Meier, Sebastián; Borie B., Gilda; Rillig, Matthias C.; Borie, Fernando (ELSEVIER, 2008-11-15)
      The amount of glomalin-related soil protein (GRSP), a glycoprotein produced by arbuscular mycorrhizal fungi (AMF), its contribution to the sequestering of Cu and Zn in the soil, and the microsite variation of other soil ...
    • Morales, Pablo E.; Torres, Gloria; Sotomayor Flores, Cristian Alejandro; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Paredes, Felipe; Chiong Lay, Mario (Academic Press Inc., 2014)
      Incretin GLP-1 has important metabolic effects on several tissues, mainly through the regulation of glucose uptake and usage. One mechanism for increasing cell metabolism is modulating endoplasmic reticulum (ER)-mitochondria ...
    • Morales, Pablo E.; Torres, Gloria; Sotomayor Torres, Cristian; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Paredes, Felipe; Chiong Lay, Mario (Elsevier, 2014)
      Incretin GLP-1 has important metabolic effects on several tissues, mainly through the regulation of glucose uptake and usage. One mechanism for increasing cell metabolism is modulating endoplasmic reticulum (ER)–mitochondria ...
    • Torres, Gloria; Morales, Pablo E.; García Miguel, Marina; Norambuena Soto, Ignacio; Cartes Saavedra, Benjamin; Vidal Pena, Gonzalo; Moncada Ruff, David; Sanhueza Olivares, Fernanda; San Martín, Alejandra; Chiong Lay, Mario (PERGAMON-ELSEVIER SCIENCE LTD., 2016)
      Glucagon-like peptide-1 (GLP-1) is a neuroendocrine hormone produced by gastrointestinal tract in response to food ingestion. GLP-1 plays a very important role in the glucose homeostasis by stimulating glucose-dependent ...
    • Marambio, Paola; Toro, Barbra; Sanhueza, Carlos; Troncoso, Rodrigo; Parra, Valentina; Verdejo, Hugo; García Nannig, Lorena; Quiroga, Clara; Munafo, Daniela; Díaz Elizondo, Jessica; Bravo Sagua, Roberto; González Burgos, María Julieta; Díaz Araya, Guillermo; Pedrozo Cibils, Zully; Chiong Lay, Mario; Co (2010)
      Aggresomes are dynamic structures formed when the ubiquitin-proteasome system is overwhelmed with aggregation-prone proteins. In this process, small protein aggregates are actively transported towards the microtubule-organizing ...
    • Mancilla, Héctor; Maldonado, Rodrigo; Cereceda, Karina; Villarroel Espíndola, Franz; Montes de Oca, Marco; Angulo, Constanza; Castro, Maite A.; Slebe, Juan C.; Vera, Juan C.; Lavandero González, Sergio (Wiley-Blackwell, 2015)
      The development and survival of male germ cells depend on the antioxidant capacity of the seminiferous tubule. Glutathione (GSH) plays an important role in the antioxidant defenses of the spermatogenic epithelium. Autophagy ...
    • Lara, Pablo; Palma Florez, Sujey; Salas Huenuleo, Edison; Polakovicova, Iva; Guerrero, Simón; Lobos González, Lorena; Campos, América; Muñoz, Luis; Jorquera Cordero, Carla; Varas Godoy, Manuel; Cancino, Jorge; Arias, Eloísa; Villegas, Jaime; Cruz, Luis J.; Albericio, Fernando; Araya, Eyleen; Corvalán, Alejandro H.; Quest, Andrew F. G.; Kogan Bocian, Marcelo (BMC, 2020)
      Background Extracellular vesicles (EVs) have shown great potential for targeted therapy, as they have a natural ability to pass through biological barriers and, depending on their origin, can preferentially accumulate at ...
    • Riveros, Ana; Dadlani, Komal; Salas, Edison; Caballero, Leonardo; Melo, Francisco; Kogan Bocian, Marcelo (American Scientific Publishers, 2013)
      There has been an increase in the research towards the use of nanoparticles as a promising tool for nanomedicine, from imagenology, drug and gene delivery, to phototherapy. Little is known regarding the interaction between ...
    • Araya, Eyleen; Olmedo, Ivonne; Bastus, Neus G.; Guerrero, Simón; Puntes, Víctor F.; Giralt, Ernest; Kogan Bocian, Marcelo (SPRINGER, 2008-11)
      Peptide-Gold nanoparticles selectively attached to beta-amyloid protein (A beta) amyloidogenic aggregates were irradiated with microwave. This treatment produces dramatic effects on the A beta aggregates, inhibiting both ...
    • Pérez Ortiz, Magdalena; Zapata Urzua, Claudio; Acosta, Gerardo A.; Álvarez Lueje, Alejandro; Albericio, Fernando; Kogan Bocian, Marcelo (Elsevier, 2017)
      In this work, the potential application of gold nanoparticles for GLP-1 analogues delivery was studied. For this purpose, the original sequence of the incretin GLP-1 was slightly modified in the C-terminal region by adding ...
    • Guerrero, Ariel R.; Hassan, Natalia; Escobar, Carlos A.; Albericio, Fernando; Kogan Bocian, Marcelo; Araya, Eyleen (Future Medicine Ltd., 2014)
      © 2014 Future Medicine Ltd. In this article, we describe how nanoparticles work in photothermally triggered drug delivery, starting with a description of the plasmon resonance and the photothermal effect, and how this is ...
    • Bastus, Neus G.; Kogan Bocian, Marcelo; Amigo, Roger; Grillo-Bosch, Dolors; Araya, Eyleen; Turiel, Antonio; Labarta, Amilcar; Giralt, Ernest; Puntes, Victor F. (2007)
      Nanoparticles can be made to respond resonantly to a time-varying electromagnetic field with advantageous results related to the transfer of energy from the exciting field to the nanoparticles. The surface of each particle ...