Browsing by Author "Ocaranza, María Paz"
Now showing items 1-20 of 26
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(LIPPINCOTT WILLIAMS & WILKINS, 2002-03)Background and objective In humans, the insertion/ deletion polymorphism in the anglotensin (Ang) I converting enzyme (ACE) gene significantly determines ACE activity. The deletion allele induces higher ACE levels and is ...
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(International Medical Science for Experimental and Clinical Research, 2002)The insertion/delection ACE polymorphism (ACE I/D) regulates different levels of circulating and tissue ACE activities, which may induce diverse adrenergic responses to physiological stimuli. The aim of this study was ...
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(LIPPINCOTT WILLIAMS & WILKINS, 2001-09)Angiotensin I is a substrate for both ACE and for neutral endopeptidase 24.11 (NEP). We hypothesized that high ACE expression is related to low NEP activity. Accordingly, circulating and tissue NEP and ACE activities were ...
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(SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), 2020)
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(Frontiers Media, 2021)An increased risk of atrial fibrillation (AF) has been demonstrated in high-performance athletes. Soluble vascular adhesion molecule-1 (sVCAM-1), a biomarker involved in inflammation and cardiac remodeling, is associated ...
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(EDICIONES DOYMA S/L, 2001-11)Introduction. Angiotensin II levels can be partially inhibited during chronic administration of angiotensin converting enzyme (ACE) inhibitors, limiting from a clinical point of view its efficacy in the treatment of ...
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(PERGAMON-ELSEVIER SCIENCE LTD, 2006-02-28)To determine circulating angiotensin-(1-7) [Ang-(1,7)] levels in rats with different angiotensin converting enzyme (ACE) genotypes and to evaluate the effect of hypertension on levels of this heptapeptide, plasma levels ...
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(ACADEMIC PRESS INC, 2000-04-21)Insulin-like growth factor-1 (IGF-1) is a natural protectant of cardiac myocytes that has been shown to improve cardiac function. The role of IGF-1 in attenuating apoptosis induced by osmotic stress (sorbitol, SOR) or by ...
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(LIPPINCOTT WILLIAMS & WILKINS, 2005-12)In humans and rats, angiotensin I-converting enzyme activity is significantly determined by a gene polymorphism. Homozygous Brown Norway rats have higher plasma angiotensin I-converting enzyme activity and circulating ...
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(LIPPINCOTT WILLIAMS & WILKINS, 2002-08)This study investigated whether long-term administration of isoproterenol (ISO) induces differential expression of angiotensin-converting enzyme (ACE) in lung, plasma, and left ventricle (LV) during development of left ...
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(EXCERPTA MEDICA INC, 2003-09-15)In patients with hypertension who have the DD-ACE genotype (higher angiotensin-converting enzyme [ACE] activity), plasma levels of angiotensin-(1-7) are 4 times lower than in patients with the II-ACE genotype (lower ACE ...
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(MOSBY-ELSEVIER, 2011-05)Background The small guanosine triphosphatase Rho and its target Rho-kinase have significant roles in experimental remodeling and ventricular dysfunction, but no data are available on Rho-kinase activation in patients with ...
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(Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2003)La mayor actividad de la enzima convertidora de angiotensina I (ECA) determina mayores niveles de angiotensina (Ang) II y menores de Ang-(1-7). Hemos observado mayores niveles de Ang II en ratas normotensas con mayor ...
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(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008-07-25)Changes in cardiac osmolarity occur in myocardial infarction. Osmoregulatory mechanisms may, therefore, play a crucial role in cardiomyocyte survival. Tonicity-responsive enhancer binding protein (TonEBP) is a key ...
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(LIPPINCOTT WILLIAMS & WILKINS, 2005-09)Administration of the P-adrenergic agonist isoproterenol results in cardiac apoptosis. The effect of short-term P-adrenergic stimulation by isoproterenol on the activity of plasma, lung, and left ventricular (LV) angiotensin ...
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(Sociedad Chilena de Cardilología y Cirugía Cardiovascular, 2005)Los polimorfismos de los receptores β Adrenérgicos (AR) influencian el grado de actividad del receptor. Los βAR tienen un rol importante en la regulación de la contractilidad y podrían tener implicancias en el riesgo de ...
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(Public Library Science, 2021)Cardiac hypertrophy is the result of responses to various physiological or pathological stimuli. Recently, we showed that polycystin-1 participates in cardiomyocyte hypertrophy elicited by pressure overload and mechanical ...
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Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats (AMER PHYSIOLOGICAL SOC, 2004-02-01)In humans, the effect of angiotensin-converting enzyme (ACE) gene polymorphisms in cardiovascular disease is still controversial. In the rat, a microsatellite marker in the ACE gene allows differentiation of the ACE gene ...
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(Sociedad Española de Cardiología, 2001)En este modelo experimental de HVI hipertensiva mixta existe una activación temprana de la ECA plasmática y cardíaca. La administración precoz de un IECA previene el desarrollo de hipertensión e HVI al inhibir el aumento ...
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(SPRINGER-VERLAG, 2001-05)In all cell types, the maintenance of normal cell volume is an essential homeostatic function. Relatively little is known about the induction of apoptosis by hyperosmotic stress and its molecular mechanism in terminally ...
