Browsing by Author "Pessoa Mahana, Carlos David"
Now showing items 1-12 of 12
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Galarce, Gloria D.; Foncea, Rocío; Edwards, Ana María; Pessoa Mahana, Hernán; Pessoa Mahana, Carlos David; Ebensperger González, Roberto (SOC BIOLGIA CHILE, 2008)This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-alpha) production inhibitors. The newly synthesized compounds were tested for their in vitro ...
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Mella Raipán, Jaime A.; Lagos, Carlos F.; Recabarren Gajardo, Gonzalo Iván; Espinosa Bustos, Christian; Romero Parra, Javier; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David (2013)A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 ...
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Mella Raipán, Jaime A.; Lagos, Carlos F.; Recabarren Gajardo, Gonzalo Iván; Espinosa Bustos, Christian; Romero Parra, Javier; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David (2013)A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 ...
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Espinosa Bustos, Christian; Lagos, Carlos F.; Romero Parra, Javier; Zárate, Ana M.; Mella Raipán, Jaime A.; Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Iturriaga-Vásquez, Patricio; Tapia, Ricardo A.; Pessoa Mahana, Carlos David (Wiley-VCH Verlag, 2015)© 2015 Wiley-VCH Verlag GmbH & Co. KGaA. A series of N-acyl-2,5-dimethoxyphenyl-1H-benzimidazoles were designed based on a CoMFA model for cannabinoid receptor type 1 (CB1) ligands. Compounds were synthesized and radioligand ...
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López Alarcón, Camilo; Lissi, E.; Hoffmann, P.; Mella, J.; Pessoa Mahana, Carlos David; Speisky Cosoy, Hernán; Möller, M.; Ferrer-Sueta, G.; Denicola, A. (2011)The reaction of 5-aminosalicylic acid (5-ASA) with nitrous acid has been studied at low pH under conditions that simulate a gastric environment. The course of the reaction was followed by UV-visible and fluorescence ...
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Méndez-Rojas, Claudio; Quiroz, Gabriel; Faúndez, Mario; Gallardo Garrido, Carlos Andrés; Pessoa Mahana, Carlos David; Chung, Hery; Gallardo Toledo, Eduardo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Kogan Bocian, Marcelo; Zúñiga López, María C.; Iturriaga-Vásquez, Patricio; (Wiley-VCH Verlag, 2018)© 2018 Deutsche Pharmazeutische Gesellschaft With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer's disease, we synthesized and evaluated ...
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Synthesis and Biological Screening of Novel Indolalkyl Arenes Targeting the Serotonine Transporter Ojeda Gómez, Claudia; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David; Recabarren Gajardo, Gonzalo Iván; Méndez Rojas, Claudio (Wiley, 2014)A series of functionalized indolylalkylarenes 3–16(a and b) were synthesized and their affinities for the serotonin transporter were investigated in vitro. Compounds 3–12(a and b) were obtained by nucleophilic substitution ...
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Pessoa Mahana, Hernán; Silva Matus, Paul Eduardo; Pessoa Mahana, Carlos David; Chung, Hery; Iturriaga-Vásquez, Patricio; Quiroz, Gabriel; Möller-Acuña, Patricia; Zapata Torres, Gerald; Saitz Barría, Claudio; Araya Maturana, Ramiro; Reyes Parada, Miguel (Wiley, 2017)A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the ...
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Pessoa Mahana, Hernán; Cuevas M., Ignacio; Pessoa Mahana, Carlos David; Araya Maturana, Ramiro; Almodovar, Iriux; Saitz Barría, Claudio (2011)The synthesis of a series of functionalized 1-Benzyl-3-[4-Aryl-1-piperazingl]carbonyl-1H-Indoles 6(a-f), as a potential new class of bioactive ligands at D4 receptors is reported. The synthetic strategy took place through ...
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Pessoa Mahana, Hernán; González Lira, Christian; Fierro, Angélica; Zapata Torres, Gerald Amilcar; Pessoa Mahana, Carlos David; Ortiz Severin, Javiera; Iturriaga-Vásquez, Patricio; Reyes Parada, Miguel; Silva Matus, Paul; Saitz Barría, Claudio; Araya Maturana, Ramiro (Elsevier, 2013)A series of 3-(3-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)propyl)-1H-indole derivatives (3a–d and 5a– f) as homo- and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter ...
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Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Temer, Jenny Fiedler; Zapata Torres, Gerald; Pessoa Mahana, Carlos David; Barría, Claudio Saitz; Araya Maturana, Ramiro (2012)A series of novel benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1- one derivatives 6a-f, 7a-f and their corresponding alcohols 8a-f were synthesized and evaluated for their affinity towards 5-HT 1A receptors. The ...
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Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Fiedler Temer, Jenny; Zapata Torres, Gerald Amilcar; Pessoa Mahana, Carlos David; Saitz Barría, Claudio; Araya Maturana, Ramiro (2012)A series of novel benzobthiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one derivatives 6a–f, 7a–f and their corresponding alcohols 8a–f were synthesized and evaluated for their affinity towards 5-HT1A receptors. The ...