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Biological evaluation of novel 6-arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion

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2008
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Galarce, Gloria D.
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Biological evaluation of novel 6-arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion
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Author
  • Galarce, Gloria D.;
  • Foncea, Rocío;
  • Edwards, Ana María;
  • Pessoa Mahana, Hernán;
  • Pessoa Mahana, Carlos David;
  • Ebensperger González, Roberto;
Abstract
This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-alpha) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-alpha secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo[1,2-c]quinazoline, coded as G1, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo[1,2-c]quinazoline derivatives may have a potential as anti-inflammatory agents.
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URI: https://repositorio.uchile.cl/handle/2250/120861
ISSN: 0716-9760
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BIOLOGICAL RESEARCH Volume: 41 Issue: 1 Pages: 43-50 Published: 2008
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