Browsing by Subject "Unfolded protein response"

Now showing items 21-25 of 25

    • Targeting the unfolded protein response for disease intervention 
      Rivas, Alexis; Vidal, René; Hetz Flores, Claudio (Taylor & Francis, 2015)
      Introduction: The accumulation of misfolded proteins in the endoplasmic reticulum (ER) generates a stress condition that engages the unfolded protein response (UPR). The UPR is an adaptive reaction that aims to reestablish ...
    • The unfolded protein response: at the intersection between endoplasmic reticulum function and mitochondrial ... 
      Carreras Sureda, Amado; Pihan Najle, Philippe; Hetz Flores, Claudio (Frontiers Media, 2017)
      Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant contribution to diseases including cancer and neurodegeneration. This ...
    • TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the ... 
      Rojas Rivera, Diego; Armisen Yáñez, Ricardo; Colombo, A.; Martínez, G.; Eguiguren, A. L.; Díaz, A.; Kiviluoto, S.; Rodríguez, D.; Patron, M.; Rizzuto, R.; Bultynck, G.; Concha Nordemann, Miguel; Sierralta, J.; Stutzin Schottlander, Andrés; Hetz Flores, Claudio (2012)
      Transmembrane BAX inhibitor motif-containing (TMBIM)-6, also known as BAX-inhibitor 1 (BI-1), is an anti-apoptotic protein that belongs to a putative family of highly conserved and poorly characterized genes. Here we report ...
    • XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy 
      Hetz Flores, Claudio; Thielen, Peter; Matus, Soledad; Nassif, Melissa; Court, Felipe; Kiffin, Roberta; Martinez, Gabriela; Cuervo, Ana María; Brown, Robert H.; Glimcher, Laurie H. (2009)
      Mutations in superoxide dismutase-1 (SOD1) cause familial amyotrophic lateral sclerosis (fALS). Recent evidence implicates adaptive responses to endoplasmic reticulum (ER) stress in the disease process via a pathway known ...
    • Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ... 
      Schiattarella, Gabriele G.; Altamirano, Francisco; Young Kim, Soo; Tong, Dan; Ferdous, Anwarul; Piristine, Hande; Dasgupta, Subhajit; Wang, Xuliang; French, Kristin M.; Villalobos, Elisa; Spurgin, Stephen B.; Waldman, Maayan; Jiang, Nan; May, Herman I.; Hill, Theodore M.; Luo, Yuxuan; Yoo, Heesoo; Zaha, Vlad G.; Lavandero González, Sergio Alejandro; Gillette, Thomas G.; Hill, Joseph A. (Nature, 2021)
      Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF. However, molecular ...