The unfolded protein response: at the intersection between endoplasmic reticulum function and mitochondrial bioenergetics
Artículo

Open/ Download
Publication date
2017Metadata
Show full item record
Cómo citar
Carreras Sureda, Amado
Cómo citar
The unfolded protein response: at the intersection between endoplasmic reticulum function and mitochondrial bioenergetics
Abstract
Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant contribution to diseases including cancer and neurodegeneration. This functional integration is exerted through discrete interorganelle structures known as mitochondria-associated membranes (MAMs). At these domains, ER/mitochondria physically associate to dynamically adjust metabolic demands and the response to stress stimuli. Here, we provide a focused overview of how the ER shapes the function of the mitochondria, giving a special emphasis to the significance of local signaling of the unfolded protein response at MAMs. The implications to cell fate control and the progression of cancer are also discussed
Patrocinador
FONDECYT
1140549
3150113
FONDAP program
15150012
Millennium Institute
P09-015-F
European Commission RD, MSCA-RISE
734749
ALS Therapy Alliance
2014-F-059
Muscular Dystrophy Association
382453
Michael J. Fox Foundation for Parkinson's Research-Target Validation
9277
CONICYT-Brazil
441921/2016-7
US Office of Naval Research Global (ONR-G)
N62909-16-1-2003
U.S. Air Force Office of Scientific Research
FA9550-16-1-0384
FONDEF
ID16I10223
D11E1007
ALSRP Therapeutic Idea Award
AL150111
Indexation
Artículo de publicación ISI Artículo de publicación SCOPUS
Identifier
URI: https://repositorio.uchile.cl/handle/2250/169767
DOI: 10.3389/fonc.2017.00055
ISSN: 2234-943X
Quote Item
Frontiers in Oncology April 2017 | Volume 7 | Article 55
Collections
The following license files are associated with this item: