The unfolded protein response: at the intersection between endoplasmic reticulum function and mitochondrial bioenergetics
Author
dc.contributor.author
Carreras Sureda, Amado
Author
dc.contributor.author
Pihan Najle, Philippe
Author
dc.contributor.author
Hetz Flores, Claudio
Admission date
dc.date.accessioned
2019-06-03T21:11:34Z
Available date
dc.date.available
2019-06-03T21:11:34Z
Publication date
dc.date.issued
2017
Cita de ítem
dc.identifier.citation
Frontiers in Oncology April 2017 | Volume 7 | Article 55
es_ES
Identifier
dc.identifier.issn
2234-943X
Identifier
dc.identifier.other
10.3389/fonc.2017.00055
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/169767
Abstract
dc.description.abstract
Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant contribution to diseases including cancer and neurodegeneration. This functional integration is exerted through discrete interorganelle structures known as mitochondria-associated membranes (MAMs). At these domains, ER/mitochondria physically associate to dynamically adjust metabolic demands and the response to stress stimuli. Here, we provide a focused overview of how the ER shapes the function of the mitochondria, giving a special emphasis to the significance of local signaling of the unfolded protein response at MAMs. The implications to cell fate control and the progression of cancer are also discussed
es_ES
Patrocinador
dc.description.sponsorship
FONDECYT
1140549
3150113
FONDAP program
15150012
Millennium Institute
P09-015-F
European Commission RD, MSCA-RISE
734749
ALS Therapy Alliance
2014-F-059
Muscular Dystrophy Association
382453
Michael J. Fox Foundation for Parkinson's Research-Target Validation
9277
CONICYT-Brazil
441921/2016-7
US Office of Naval Research Global (ONR-G)
N62909-16-1-2003
U.S. Air Force Office of Scientific Research
FA9550-16-1-0384
FONDEF
ID16I10223
D11E1007
ALSRP Therapeutic Idea Award
AL150111