Now showing items 7465-7484 of 11553

    • Campos Estrada, Carolina; González Herrera, Fabiola; Greif, Gonzalo; Carrillo Werner, Ileana; Guzmán Rivera, Daniela; Liempi Manquel, Ana; Robello, Carlos; Kemmerling Weis, Ulrike; Castillo Rivas, Christian; Maya Arango, Juan Diego (Wiley, 2020)
      Chagas disease is a vector-borne disease caused by the protozoan parasite Trypanosoma cruzi. Current therapy involves benznidazole. Benznidazole and other drugs can modify gene expression patterns, improving the response ...
    • Gallardo Vera, Andrés; Latapiat, Verónica; Rivera, Alejandra; Fonseca, Beatriz; Roldán, Andrés; Sandoval, Patricio; Sánchez, Carolina; Matamala Capponi, José (Elsevier, 2020)
      Introduction: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary stroke disorder caused by mutations in the NOTCH3 gene. We report the first Chilean ...
    • Castillo C., Octavio A.; Ivar Vidal, M.; Rodrigo Campos, P.; Alejandro Fonerón, V.; Miguel Feria, F.; Francisco Sepúlveda, T. (Sociedad de Cirujanos de Chile, 2010)
      Introduction: Natural orifice transluminal endoscopic surgery (NOTES) and Laparoendoscopic Single Site Surgery (LESS) are emerging technologies, which allows to performed surgical procedures avoiding any surgical scars. ...
    • Altamirano Assad, Roberto (Sociedad Chilena de Obstetricia y GinecologiaRoman Diaz 205, Officina 205, 2020)
    • Huenchuguala, Sandro; Sjödin, Birgitta; Mannervik, Bengt; Segura-Aguilar, Juan (Springer New York LLC, 2019)
      © 2018, Springer Science+Business Media, LLC, part of Springer Nature.Aminochrome induces neurotoxic alpha-synuclein oligomer formation relevant to the etiology of Parkinson’s disease. Oxidative stress produces aminochrome ...
    • Cortés, Leonel A.; Castro, Lorena; Pesce Reyes, Bárbara; Maya Arango, Juan; Ferreira, Jorge; Castro Castillo, Vicente; Parra, Eduardo; Jara, José A.; López Muñoz, Rodrigo (Public Library Science, 2015)
      Chagas disease is one of the most neglected tropical diseases in the world, affecting nearly 15 million people, primarily in Latin America. Only two drugs are used for the treatment of this disease, nifurtimox and benznidazole. ...
    • Garrido, Leonardo; Toledo Araya, Héctor (BLACKWELL PUBLISHING, 2007-10)
      Helicobacter pylori is a pathogenic bacterium that infects a half of the human population. In Chile, between 55% and 79% of people are colonized by H. pylori . At present, therapeutic strategies to eradicate the ...
    • Arancibia, Sergio; Espinoza, Cecilia; Salazar, Fabián; Campo, Miguel del; Tampe, Ricardo; Zhong, Ta- Ying; Ioannes, Pablo de; Moltedo, Bruno; Ferreira Parker, Jorge; Lavelle, Ed C.; Manubens, Augusto; Ioannes, Alfredo de; Becker, María Inés (PLOS One, 2014)
      Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as immunomodulatory proteins with proven anti-cancer properties. The biodiversity of hemocyanins has promoted interest in identifying new ...
    • Carrasco, Carmen A.; González, Alexis A.; Carvajal, Cristián A.; Campusano, Claudia; Oestreicher, Eveline; Artega, Eugenio; Wohllk González, Nelson; Fardella, Carlos E. (ENDOCRINE SOC, 2004-08)
      Primary hyperparathyroidism may occur as part of hereditary syndromes, including multiple endocrine neoplasia types 1 and 2A (MEN1 and MEN2A), hyperparathyroidism-jaw tumor syndrome, and the familial isolated hyperparathyroidism ...
    • Mendoza, Carolina; Olguín, Patricio; Lafferte, Gabriela; Thomas, Ulrich; Ebitsch, Susanne; Gundelfinger, Eckart D.; Kukuljan Padilla, Manuel; Sierralta, Jimena (2003)
      Drosophila discs-large (dlg) mutants exhibit multiple developmental abnormalities, including severe defects in neuronal differentiation and synaptic structure and function. These defects have been ascribed to the loss of ...
    • Visser, W. Edward; Jansen, Jurgen; Friesema, Edith C.H.; Kester, Monique H.A.; Mancilla, Edna; Lundgren, Johan; Van Der Knaap, Marjo S.; Lunsing, Roelineke J.; Brouwer, Oebele F.; Visser, Theo J. (2009)
      Monocarboxylate transporter 8 (MCT8; approved symbol SLC16A2) facilitates cellular uptake and efflux of 3,3′,5-triiodothyronine (T3). Mutations in MCT8 are associated with severe psychomotor retardation, high serum T3 and ...
    • Westermeier, Francisco; Bustamante, Mario; Pavez, Mario; García Nannig, Lorena; Chiong Lay, Mario; Ocaranza, María Paz; Lavandero González, Sergio (Elsevier, 2015)
      Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic ...
    • Vidal Álvarez, Roberto; Roessler, Patricia; Solari, Verónica; Vollaire, Jimena; Jiang, Xi; Matson, David O.; Mamani, Nora; Prado Jiménez, Valeria; O'Ryan Gallardo, Miguel (AMER SOC MICROBIOLOGY, 2006-06)
      Capsid and polymerase (RdRp) genes of 13 norovirus outbreak strains from Chile were compared. The genes sequences were discordant for five strains, and recombination was confirmed for two of them by amplification of a ...
    • Vera, Sergio; Martinez, Rolando; Gormaz, Juan Guillermo; Gajardo, Abraham; Galleguillos, Fernanda; Rodrigo Salinas, Ramón (Informa Healthcare, 2015)
      © 2015 Informa UK, Ltd. Sepsis is a systemic uncontrolled inflammatory response in the presence of an infection. It remains a major cause of morbidity and mortality in hospitalized patients. According to its severity, ...
    • Morales, Javier O.; McConville, Jason T. (Informa Healthcare, 2014)
      For years now, the delivery of small molecules through the buccal mucosal route has been described in the literature, but it has only been over the past decade that investigations into macromolecule delivery via the buccal ...
    • Spritzer, P. M.; Motta, A. B.; Sir Petermann, Teresa; Diamanti Kandarakis, E. (Edizioni Minerva Medica, 2015)
      Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting reproductive-aged women. PCOS has been recognized as a syndrome combining reproductive and metabolic abnormalities with lifelong health implications. ...
    • Fernández Gajardo, Rodrigo; Matamala, José Manuel; Carrasco, Rodrigo; Gutiérrez, Rodrigo; Melo, Rómulo; Rodrigo Salinas, Ramón (2014)
      Traumatic brain injury (TBI) is the most important cause of disability in individuals under the age of 45 years and thus represents a significant social and economic burden. Evidence strongly suggests that oxidative stress ...
    • Rojas, X.; Marín, G.; Wallman, J. (2009)
      We studied the stimulus characteristics necessary for the expression of c-fos protein in optokinetic system neurons using immunocytochemistry. Using whole-field visual motion as a stimulus, we found substantial c-fos ...
    • Prado Guzmán, Jorge Ignacio (2012)
    • Henríquez Olguín, Carlos; Díaz Vegas, Alexis; Utreras Mendoza, Yildy; Campos Acevedo, Cristian; Arias Calderón, Manuel; Llanos Vidal, Paola; Contreras Ferrat, Ariel Eduardo; Espinosa Escalona, Alejandra; Altamirano, Francisco; Jaimovich Pérez, Enrique; Valladares Ide, Denisse (Frontiers Media, 2016)
      Reactive oxygen species (ROS) participate as signaling molecules in response to exercise in skeletal muscle. However, the source of ROS and the molecular mechanisms involved in these phenomena are still not completely ...