Now showing items 9882-9901 of 11166

    • Cortes Troncoso, Juan; Jang, Shyh-Ing; Pérez, Paola; Hidalgo, Jorge; Ikeuchi, Tomoko; Greenwell-Wild, Teresa; Warner, Blake M.; Moutsopoulos, Niki M.; Alevizos, Ilias (The American Society for Clinical Investigation, 2020)
      Sjogren's syndrome (SS) is a systemic autoimmune disease that mainly affects exocrine salivary and lacrimal glands. Local inflammation in the glands is thought to trigger glandular dysfunction and symptoms of dryness. ...
    • Giraudon, Pascale; Szymocha, Raphaël; Buart, Stéphanie; Bernard, Arlette; Cartier Rovirosa, Luis; Belin, Marie Françoise; Akaoka, Hideo (American Association of Immunologists, 2000)
      Activation of T lymphocytes by human pathogens is a key step in the development of immune-mediated neurologic diseases. Because of their ability to invade the CNS and their increased secretion of proinflammatory cytokines, ...
    • Fones, Elizabeth; Amigo, Hannelore; Gallegos, Kimie; Guerrero, Anibal; Ferreira, Jorge (1989)
      The effect of t-butyl-4-hydroxyanisole (BHA), a widely used food antioxidant additive, on the culture growth, oxygen consumption, and redox state of some electron carriers of intact TA3 and 786A ascites tumor cells has ...
    • Aldunate, Jorge; Ferreira, Jorge; Letelier Muñoz, María Eugenia; Repetto Scaramelli, Yolanda; Morello Casté, Antonio (1986)
      t-Butyl-4-hydroxyanisole, an antioxidant food additive, inhibited the growth of Trypanosoma cruzi by almost 100% at 0.5 mM concentration. This compound inhibited 70% of oxygen consumption of epimastigotes. The redox level ...
    • Ibberson, Mark R.; Copier, John P.; Llop Romero, Elena; Navarrete, Cristina; Hill, Adrian V.S.; Cruickshank, J. Kennedy; So, Alex K.L. (1998)
      Interactions involving the T-cell receptor (TCR) and major histocompatibility complex (MHC) are fundamental to the generation of a specific immune response. The study of interpopulation differences in TCR genes may identify ...
    • Aravena, Mauricio; Pérez, C.; Pérez, V.; Acuña Castillo, Claudio; Gómez, Christian; Leiva Salcedo, Elías; Nishimura, Sumiyo; Sabaj, B.; Walter, Robin Ann (ELSEVIER SCI IRELAND LTD, 2005-03)
      T-kininogen (T-KG) is a precursor of T-kinin, the most abundant kinin in rat serum, and also acts as a strong and specific cysteine proteinase inhibitor. Its expression is strongly induced during aging in rats, and expression ...
    • Pérez, Viviana; Leiva Salcedo, Elías; Acuña Castillo, Claudio; Aravena, Mauricio; Gómez, Christian; Sabaj Diez, Valeria; Colombo, Alicia; Nishimura, Sumiyo; Pérez Núñez, Claudio; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2006-03)
      Basal proliferation of endothelial cells increases with age, and this might play a role in the etiology of age-related vascular diseases, as well as angiogenesis. Serum kininogen levels increase during aging in rats and ...
    • Leiva-Salcedo, Elias; Perez, Viviana; Acuña Castillo, Claudio; Walter, Robin Ann; Sierra, Felipe (Society of Biology of Chile, 2002)
      Serum levels of T-kininogen increase dramatically as rats approach the end of their lifespan. Stable expression of the protein in Balb/c 3T3 fibroblasts leads to a dramatic inhibition of cell proliferation, as well as ...
    • Acuña Castillo, Claudio; Aravena, Mauricio; Leiva Salcedo, Elías; Pérez, Viviana; Gómez, Christian; Sabaj Diez, Valeria; Nishimura, Sumiyo; Pérez Núñez, Claudio; Colombo, Alicia; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2005-12)
      Plasma levels of kininogens increase with age in both rats and humans. Kininogens are inhibitors of cysteine proteinases, and filarial cysteine proteinase inhibitors (cystatins) reduce the proliferation of T cells. We ...
    • Acuña Castillo, Claudio; Leiva-Salcedo, Elias; Gómez, Christian R.; Pérez, Viviana; Li, Min; Torres, Claudio; Walter, Robin Ann; Murasko, Donna M.; Sierra, Felipe (Gerontological Society of America, 2006)
      T-kininogen (T-KG) is a reliable biomarker of aging in male Sprague-Dawley rats. Here we confirm, in a longitudinal study, a similar behavior in Fisher 344 rats of both sexes. In males, the increase in serum levels of T-KG ...
    • Díaz Zúñiga, Jaime; Melgar Rodríguez, Samanta; Alvarez, C.; Monasterio, G.; Benítez, A.; Ciuchi, P.; Díaz, C.; Mardones, J.; Escobar, A.; Sanz, M.; Vernal Astudillo, Rolando (Blackwell Munksgaard, 2015)
      & Sons Ltd. Background and Objective: Based on lipopolysaccharide (LPS) antigenicity, different Aggregatibacter actinomycetemcomitans serotypes have been described. Serotype b strains have demonstrated a stronger capacity ...
    • Maldonado Maldonado, Edio Luis; Rojas, Diego A.; Urbina, Fabiola; Solari Illescas, Aldo Gerónimo (Public Library Science, 2021)
      The unicellular protozoan Trypanosoma cruzi is the causing agent of Chagas disease which affects several millions of people around the world. The components of the cell signaling pathways in this parasite have not been ...
    • Deborggraeve, Stijn; Coronado, Ximena; Solari Illescas, Aldo; Zulantay Alfaro, Inés; Apt Baruch, Werner; Mertens, Pascal; Laurent, Thierry; Leclipteux, Thierry; Stessens, Tim; Dujardin, Jean Claude; Herdewijn, Piet; Büscher, Philippe (2009)
      Background: PCR has evolved into one of the most promising tools for T. cruzi detection in the diagnosis and control of Chagas disease. However, general use of the technique is hampered by its complexity and the lack of ...
    • Hollander, C. S.; Mitsuma, T.; Shenkman, L.; Stevenson, C.; Pineda, G.; Silva, E. (1972)
      In contrast to experience in New York where the frequency of triiodothyronine (T3) toxicosis among hyperthyroid patients is 4%, 56 (12·5%) of 449 patients in Chile, an area of iodine deficiency, were hyperthyroid by clinical ...
    • Erazo Bahamondes, Marcia; Amigo Cartagena, Hugo; Oyarzún Gómez, Manuel; Peruga U., Armando (SOC MEDICA SANTIAGO, 2008-10)
      Background: The association between lung cancer and smoking is well documented. However there is less information about the estimation of its attributable fraction and population burden. Aim: To estimate the attributable ...
    • Amigo Cartagena, Hugo; Erazo Bahamondes, Marcia; Oyarzún Gómez, Manuel; Bello S., Sergio; Peruga U., Armando (2006)
      Background: Smoking is the main risk factor for Chronic Obstructive Pulmonary Disease (COPD), an important cause of morbidity and mortality. Aim: To estimate smoking attributable risk and population attributable risk in ...
    • Lizama, Carlos; Rojas-Benítez, Diego; Antonelli, Marcelo; Ludwig, Andreas; Bustamante-Marín, Ximena; Brouwer-Visser, Jurriaan; Moreno, Ricardo D. (2010)
      The pathways leading to male germ cell apoptosis in vivo are poorly understood, but are highly relevant for the comprehension of sperm production regulation by the testis. In this work, we show the evidence of a mechanism ...
    • Sánchez, Gina; Pedrozo Cibils, Zully; Domenech Lira, Raúl; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2005-12)
      We have shown previously that electrically induced tachycardia effectively produces myocardial preconditioning. Among other effects, tachycardia increases calcium release rates in microsomal fractions enriched in sarcoplasmic ...
    • Domenech Lira, Raúl; Macho Fisher, Pilar; Vélez, Diego; Sánchez, Gina; Liu, Xueliang; Dhalla, Naranjan (Lippincott Williams and Wilkins, 1998)
      Background - Myocardial ischemic preconditioning is a well-known phenomenon, however there is scant information in regard to nonischemic preconditioning. Methods and Results - We studied in anesthetized dogs the preconditioning ...
    • Meyer, Lital; Concepción, Roberto; Zamorano, Nibaldo; Armstrong, Macarena; Castro, Leonardo; Mujica, Maximiliano; Asenjo, Rene (2012)
      Tachycardiomyopathy is a potentially reversible cause of heart failure. It can be induced by supraventricular or ventricular arrhythmias. When these are treated, systolic function improves or normalizes. We report a 20 ...