Browsing by Subject "Endoplasmic reticulum stress"

Now showing items 1-15 of 15

    • AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation ... 
      Zuleta, Amparo; Vidal, Rene L.; Armentano, Donna; Parsons, Geoffrey; Hetz Flores, Claudio (2012)
      Huntington's disease (HD) is caused by mutations that expand a polyglutamine region in the amino-terminal domain of Huntingtin (Htt), leading to the accumulation of intracellular inclusions and progressive neurodegeneration. ...
    • Aberrant MUC1 accumulation in salivary glands of Sjogren's syndrome patients is reversed by TUDCA in vitro 
      Castro Masso, Isabel; Albornoz, Nicolás; Aguilera, Sergio; Barrera, María José; González, Sergio; Núñez, Matilde; Carvajal, Patricia; Jara, Daniela; Lagos, Carolina; Molina, Claudio; Urzúa Tobar, Ulises; Hermoso, Marcela; González Burgos, María Julieta (Oxford University Press, 2020)
      Objectives. Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate ...
    • Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents ... 
      Ayala, Pedro; Montenegro, José; Vivar, Raúl; Letelier, Alan; Urroz, Pablo Aránguiz; Copaja, Miguel; Pivet, Deisy; Humeres, Claudio; Troncoso, Rodrigo; Vicencio, José Miguel; Lavandero González, Sergio; Díaz Araya, Guillermo (2012)
      Increasing evidence indicates that endoplasmic reticulum (ER) stress is involved in various diseases. In the human heart, ischemia/reperfusion has been correlated to ER stress, and several markers of the unfolded protein ...
    • Endoplasmic reticulum proteostasis impairment in aging 
      Martínez Bravo, Gabriela; Durán Aniotz, Claudia; Cabral Miranda, Felipe; Vivar, Juan P.; Hetz Flores, Claudio (Blackwell, 2017)
      Perturbed neuronal proteostasis is a salient feature shared by both aging and protein misfolding disorders. The proteostasis network controls the health of the proteome by integrating pathways involved in protein synthesis, ...
    • Gene therapy to target ER stress in brain diseases 
      Valenzuela, Vicente; Martínez, Gabriela; Durán Aniotz, Claudia; Hetz Flores, Claudio (Elsevier B.V., 2016)
      © 2016 Elsevier B.V. Gene therapy based on the use of Adeno-associated viruses (AAVs) is emerging as a safe and stable strategy to target molecular pathways involved in a variety of brain diseases. Endoplasmic reticulum ...
    • Helicobacter pylori and gastric cancer: adaptive cellular mechanisms involved in disease progression 
      Díaz, Paula; Valenzuela Valderrama, Manuel; Bravo, Jimena; Quest, Andrew F. G. (Frontiers Media SA, 2018)
      Helicobacter pylori (H. pylori) infection is the major risk factor associated with the development of gastric cancer. The transition from normal mucosa to non-atrophic gastritis, triggered primarily by H. pylori infection, ...
    • Herp depletion protects from protein aggregation by up-regulating autophagy 
      Quiroga, Clara; Gatica, Damián; Paredes, Felipe; Bravo, Roberto; Troncoso, Rodrigo; Pedrozo Cibils, Zully; Rodríguez, Andrea E.; Toro, Barbra; Chiong Lay, Mario; Vicencio Bustamante, José Manuel; Hetz Flores, Claudio; Lavandero González, Sergio (Elsevier, 2013)
      Herp is an endoplasmic reticulum (ER) stress inducible protein that participates in the ER-associated protein degradation (ERAD) pathway. However, the contribution of Herp to other protein degradation pathways like autophagy ...
    • IRE1 signaling exacerbates Alzheimer's disease pathogenesis 
      Durán Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Alvaro O.; Medinas Bilches, Danilo; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G.; Hoozemans, Jeroen J. M.; Hetz Flores, Claudio (Springer, 2017)
      Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded ...
    • Lack of activation of the unfolded protein response in mouse and cellular models of Niemann-Pick type C disease 
      Klein, Andres; Mosqueira, Matías; Martínez, Gabriela; Robledo, Fermín; González, Marcela; Caballero, Benjamín; Cancino, Gonzalo I.; Alvarez, Alejandra R.; Hetz Flores, Claudio; Zanlungo, Silvana (2011)
      Background: Niemann-Pick type C (NPC) disease is a fatal lysosomal storage disease related to progressive neurodegeneration secondary to abnormal intracellular accumulation of cholesterol. Signs of endoplasmic reticulum ...
    • The need of a new and more physiological preclinical model for Parkinson’s disease 
      Segura Aguilar, Juan; Paris Pizarro, Irmgard; Muñoz, Patricia (Springer, 2016)
    • Pro-inflammatory cytokines enhance ERAD and ATF6 alpha pathway activity in salivary glands of Sjogren's ... 
      Barrera, María José; Aguilera, Sergio; Castro, Isabel; Cortés Araya, Juan Eliecer; Bahamondes Lorca, Verónica; Quest, Andrew F. G.; Molina, Claudio; González, Sergio; Hermoso Ramello, Marcela; Urzúa Tobar, Ulises; Leyton, Cecilia; González Burgos, María Julieta (Elsevier, 2016)
      Salivary gland (SG) acinar-cells are susceptible to endoplasmic reticulum (ER) stress related to their secretory activity and the complexity of synthesized secretory products. SGs of Sji5gren's syndrome patients (SS)-patients ...
    • The need of a new and more physiological preclinical model for Parkinson's disease 
      Segura Aguilar, Juan; Paris Pizarro, Irmgard; Muñoz, Patricia (Birkhauser Verlag AG, 2016)
    • The nerve growth factor alters calreticulin translocation from the endoplasmic reticulum to the cell surface ... 
      Vera, Carolina Andrea; Oróstica Arévalo, María Lorena; Gabler Neale, Fernando; Ferreira, Arturo; Selman,; Vega Blanco, María Margarita; Romero Osses, Carmen (Spandidos Publications, 2017)
      Ovarian cancer is the seventh most common cancer among women worldwide, causing approximately 120,000 deaths every year. Immunotherapy, designed to boost the body's natural defenses against cancer, appears to be a promising ...
    • The unfolded protein response: at the intersection between endoplasmic reticulum function and mitochondrial ... 
      Carreras Sureda, Amado; Pihan Najle, Philippe; Hetz Flores, Claudio (Frontiers Media, 2017)
      Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant contribution to diseases including cancer and neurodegeneration. This ...
    • XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy 
      Hetz Flores, Claudio; Thielen, Peter; Matus, Soledad; Nassif, Melissa; Court, Felipe; Kiffin, Roberta; Martinez, Gabriela; Cuervo, Ana María; Brown, Robert H.; Glimcher, Laurie H. (2009)
      Mutations in superoxide dismutase-1 (SOD1) cause familial amyotrophic lateral sclerosis (fALS). Recent evidence implicates adaptive responses to endoplasmic reticulum (ER) stress in the disease process via a pathway known ...