Browsing by Subject "Neurodegeneration"
Now showing items 1-20 of 32
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(Elsevier, 2018)Alterations in the buffering capacity of the proteostasis network are a salient feature of Alzheimer's disease, associated with the occurrence of chronic endoplasmic reticulum (ER) stress. To cope with ER stress, cells ...
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(Bentham Science, 2016)The pharmacological treatment of Parkinson's disease (PD) is limited to dopamine agonists and anti-cholinergic drugs that do not stop the progress of disease. L-Dopa was introduced to the treatment in 1967; this drug is ...
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(Bentham Science Publishers B.V., 2016)© 2016 Bentham Science Publishers.The pharmacological treatment of Parkinsońs disease (PD) is limited to dopamine agonists and anti-cholinergic drugs that do not stop the progress of disease. LDopa was introduced to the ...
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(Impact Journals LLC, 2017)
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(Springer New York LLC, 2016)© 2015, Springer Science+Business Media New York.In this study, we investigated the role of adducts formation between aminochrome and tubulin and its interference in microtubules assembly and stability in aminochrome-induced ...
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(2013)Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta and the accumulation of intracellular ...
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(American Chemical Society, 2017)© 2017 American Chemical Society. In 1967, L-dopa was introduced as part of the pharmacological therapy of Parkinson's disease (PD) and, in spite of extensive research, no additional effective drugs have been discovered ...
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(Public Library Science, 2020)Caenorhabditis elegans and its cognate bacterial diet comprise a reliable, widespread model to study diet and microbiota effects on host physiology. Nonetheless, how diet influences the rate at which neurons die remains ...
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(Frontiers Media S.A., 2016)
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(Frontiers Media, 2016-04)
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(Frontiers Media S.A., 2017)
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(Springer, 2015)Neurodegenerative diseases of the central nervous system are characterized by pathogenetic cellular and molecular changes in specific areas of the brain that lead to the dysfunction and/or loss of explicit neuronal ...
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(Taylor and Francis Inc., 2012)Huntington disease (HD) is caused by an extended polyglutamine [poly(Q)] stretch in the Huntingtin (HTT) protein, and is associated with the accumulation of intracellular protein aggregates, onset of progressive chorea, ...
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(MDPI, 2021)The role of docosahexaenoic acid (DHA) and arachidonic acid (AA) in neurogenesis and brain development throughout the life cycle is fundamental. DHA and AA are long-chain polyunsaturated fatty acids (LCPUFA) vital for ...
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DT-diaphorase protects against autophagy induced by aminochrome dependent alpha synuclein oligomers (Springer, 2017)Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both their formation and their neurotoxicity. However, ...
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(Wiley, 2018)Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid- peptides or phosphorylated tau proteins. Accumulating ...
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(Frontiers Media S.A., 2018)Copyright © 2018 García-González, Cabral-Miranda, Hetz and Osorio. Emerging evidence suggests that the immune and nervous systems are in close interaction in health and disease conditions. Protein aggregation and proteostasis ...
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(Taylor and Francis Inc., 2012)Protein folding stress is a salient feature of the most frequent neurodegenerative diseases. Although the accumulation of abnormally folded proteins is a well-characterized event underlying the pathology, the way cells ...
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(Frontiers Media S.A., 2018)© 2018 Müller, Ahumada-Castro, Sanhueza, Gonzalez-Billault, Court and Cárdenas.Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several ...