Browsing by Subject "Neurodegenerative diseases"

Now showing items 1-6 of 6

    • Clock genes, inflammation and the immune system-implications for diabetes, obesity and neurodegenerative diseases 
      Vieira, Elaine; Mirizio, Gerardo Gabriel; Barin, Geovana Reichert; De Andrade, Rosangela Vieira; Nimer, Nidah Fawzi Said; La Sala, Lucía (MDPI, 2020)
      Inflammation is a common feature of several diseases, including obesity, diabetes and neurodegenerative disorders. Circadian clock genes are expressed and oscillate in many cell types such as macrophages, neurons and ...
    • Feeling, learning from and being aware of inner states: interoceptive dimensions in neurodegeneration and stroke 
      García Cordero, Indira; Sedeño, Lucas; De La Fuente, Laura; Slachevsky Chonchol, Andrea; Forno, Gonzalo; Klein, Francisco; Lillo Zurita, Patricia; Ferrari, Jesica; Rodríguez, Clara; Bustin, Julian; Torralva, Teresa; Báez, Sandra; Yoris, Adrián; Esteves, Sol; Melloni, Margherita; Salamone, Paula; Huepe, David; Manes, Facundo; García, Adolfo; Ibáñez, Agustín (Royal Society, 2016)
      Interoception is a complex process encompassing multiple dimensions, such as accuracy, learning and awareness. Here, we examined whether each of those dimensions relies on specialized neural regions distributed throughout ...
    • Imaging biomarkers in neurodegeneration: current and future practices 
      Young, Peter N. E.; Estarellas, Mar; Coomans, Emma; Srikrishna, Meera; Beaumont, Helen; Maass, Anne; Venkataraman, Ashwin V.; Lissaman, Rikki; Jiménez Fernández, Daniel; Betts, Matthew J.; McGlinchey, Eimear; Berron, David; O’Connor, Antoinette; Fox, Nick c.; Pereira, Joana B.; Jagust, William; Carter, Stephen F.; Paterson, Ross W.; Schöll, Michael (BMC, 2020)
      There is an increasing role for biological markers (biomarkers) in the understanding and diagnosis of neurodegenerative disorders. The application of imaging biomarkers specifically for the in vivo investigation of ...
    • Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications ... 
      Ferrada, Evandro; Arancibia, Verónica; Loeb, Bárbara; Norambuena, Ester; Olea Azar, Claudio; Huidobro Toro, Juan Pablo (2007)
      Successful trials with 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, CQ) for Alzheimer's disease treatment prompted renewed interest in assessing whether its therapeutic action is related to the coordination of neurotoxic ...
    • Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer's disease 
      Durán Aniotz, Claudia; Cornejo, Víctor Hugo; Hetz Flores, Claudio (Oxford University Press, 2016)
      This scientific commentary refers to 'Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse', by Peng et al. (doi:10.1093/brain/awv385).
    • Upregulation of γ-glutamate-cysteine ligase as part of the long-term adaptation process to iron accumulation ... 
      Aguirre, Pabla; Valdés, Pamela; Aracena Parks, Paula; Tapia, Victoria; Núñez González, Marco (2007)
      Reactive iron is an important prooxidant factor, whereas GSH is a crucial component of a long-term adaptive system that allows cells to function during extended periods of high oxidative stress. In this work, the adaptive ...