Now showing items 2121-2140 of 11593

    • Garrido, Maritza P.; Vera, Carolina; Vega Blanco, María Margarita; Quest, Andrew F. G.; Romero Osses, Carmen (SAGE Publications Inc., 2018)
      © The Author(s), 2018. Background: Epithelial ovarian cancer (EOC) is characterized by exacerbated angiogenesis regulated by proangiogenic and growth factors. Nerve growth factor (NGF) is overexpressed in EOC where it ...
    • Bruna, Bárbara; Lobos, Pedro; Herrera Molina, Rodrigo; Hidalgo Tapia, María Cecilia; Paula Lima, Andrea; Adasme, Tatiana (Elsevier B.V., 2018)
      © 2018 Elsevier Inc. The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) induces complex neuronal signaling cascades that are critical for the cellular changes underlying synaptic plasticity. These pathways include ...
    • Echeverría, F.; Valenzuela, R.; Espinosa, A.; Bustamante, A.; Álvarez, D.; González Mañan, Daniel; Ortiz, M.; Soto Alarcón, Sandra A.; Videla Cabrera, Luis (Elsevier Inc., 2019)
      © 2018 Elsevier Inc. High-fat diet (HFD)-fed mice show obesity with development of liver steatosis and a proinflammatory state without establishing an inflammatory reaction. The aim of this work was to assess the hypothesis ...
    • Villanueva, Andrea A.; Puvogel, Sofía; Lois, Pablo; Muñoz-Palma, Ernesto; Ramírez Orellana, Manuel; Lubieniecki, Fabiana; Casco Claro, Fernando; Gallegos, Iván; García-Castro, Javier; Sanchez-Gomez, Pilar; Torres, Vicente A.; Palma, Verónica (Taylor and Francis Inc., 2018)
      © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Neuroblastoma (NB) is the most common pediatric extracranial solid tumor. It arises during development of the sympathetic nervous system. Netrin-4 (NTN4), ...
    • Catalan-Figueroa, Johanna; Boisset, Constanza B.; Jara, Miguel O.; Flores, Mario E.; Moreno-Villoslada, Ignacio; Fiedler, Jenny L.; Morales, Javier O. (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In ...
    • Benites, Julio; Toledo, Héctor; Salas, Felipe; Guerrero, Angélica; Rios, David; Valderrama, Jaime A.; Calderon, Pedro Buc (2018)
      Infection by Helicobacter pylori increases 10 times the risk of developing gastric cancer. Juglone, a natural occurring 1,4-naphthoquinone, prevents H. pylori growth by interfering with some of its critical metabolic ...
    • Stoore, Caroll; Andrade, Constanza; Hidalgo, Christian; Corrêa, Felipe; Jiménez, Mauricio; Hernandez, Marcela; Paredes, Rodolfo (BioMed Central Ltd., 2018)
      © 2018 The Author(s). Background: Natural parasite infection occurs in wild and domestics animals with more than one parasite species at the same time, generating an infection called polyparasitism. Cystic echinococcosis ...
    • Chaparro, Alejandra; Zúñiga, Edgardo; Varas-Godoy, Manuel; Albers, Daniela; Ramírez, Valeria; Hernández, Marcela; Kusanovic, Juan Pedro; Acuña-Gallardo, Stephanie; Rice, Gregory; Illanes, Sebastián E. (Wiley-Blackwell, 2018)
      © 2018 American Academy of Periodontology. Background: Gestational diabetes mellitus (GDM) affects around 7% to 10% of all pregnancies. Early detection of predisposition to GDM is the first step in developing efficacious ...
    • Estica R., Marcos; Seelenfreund H., Daniela; Durruty A., Pilar; Briones B., Gloria (Sociedad Medica de Santiago, 2018)
      We report a 21 years old woman, without offspring, with diabetes mellitus diagnosed at 17 years of age, without ketosis or weight loss. Her body mass index was 18 kg/m2. Her C peptide was normal (2.3 ng/ml) and diabetes ...
    • Brahm Barril, Javier; Urzúa Manchego, Álvaro; Poniachik Teller, Jaime; Cáceres, Dante D.; Carreño, Laura; Luca Venegas, Mauricio Pascual de (Sociedad Medica de Santiago, 2018)
      © 2018, Sociedad Medica de Santiago. All rights reserved. Background. Host genetic predispositions may be important determinants of liver fibrosis in patients with chronic hepatitis C (CHC). The association between ...
    • Werlinger, Fabiola; Cáceres, Dante D. (Sociedad Medica de Santiago, 2018)
      © 2018, Sociedad Medica de Santiago. All rights reserved. Background: Confusion in observational epidemiological studies distorts the relationship between exposure and event. “Step by step” regression models, diverts the ...
    • Macias-Kauffer, Luis R.; Villamil-Ramírez, Hugo; León-Mimila, Paola; Jacobo-Albavera, Leonor; Posadas-Romero, Carlos; Posadas-Sánchez, Rosalinda; López-Contreras, Blanca E.; Morán-Ramos, Sofía; Romero-Hidalgo, Sandra; Acuña Alonzo, Víctor; del-Río-Navarro, Blanca E (Elsevier Ireland Ltd, 2018)
      © 2018 Elsevier B.V.Background: Serum uric acid (SUA) is a heritable trait associated with cardiovascular risk factors and coronary artery disease (CAD). Genome wide association studies (GWAS) have identified several genes ...
    • Russell, Ashley L.; Tasker, Jeffrey G.; Lucion, Aldo B.; Fiedler, Jenny; Munhoz, Carolina D.; Wu, Tao yiao John; Deak, Terrence (Blackwell Publishing Ltd, 2018)
      © 2018 British Society for Neuroendocrinology Effective coordination of the biological stress response is integral for the behavioural well-being of an organism. Stress reactivity is coordinated by an interplay of the ...
    • Casanova, José Patricio; Aguilar-Rivera, Marcelo; Rodríguez, María de los Ángeles; Coleman, Todd P.; Torrealba, Fernando (American Physiological Society, 2018)
      © 2018 American Physiological Society. All rights reserved. The interoceptive insular cortex is known to be involved in the perception of bodily states and emotions. Increasing evidence points to an additional role for the ...
    • Ovalle, J. Tomás; La Cruz, Nikita L.; Reich Morales, Martín; Barra, Fernando; Simon, Adam C.; Konecke, Brian A.; Rodriguez-Mustafa, María A.; Deditius, Artur P.; Childress, Tristan M.; Morata Céspedes, Diego (Nature Publishing Group, 2018)
      © 2018, The Author(s). The genetic link between magmas and ore deposit formation is well documented by studies of fossil hydrothermal systems associated with magmatic intrusions at depth. However, the role of explosive ...
    • Sotomayor, Camilo G.; Gomes-Neto, António W.; Gans, Rijk O.B.; de Borst, Martin H.; Berger, Stefan P.; Rodrigo Salinas, Ramón; Navis, Gerjan J.; Touw, Daan J.; Bakker, Stephan J.L. (MDPI AG, 2018)
      © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with cardiovascular and all-cause mortality in renal transplant recipients ...
    • Binder, Alexandra M.; Stiemsma, Leah T.; Keller, Kristen; Van Otterdijk, Sanne D.; Mericq, Verónica; Pereira, Ana; Santos, José Luis; Shepherd, John; Michels, Karin B. (BioMed Central Ltd., 2018)
      © 2018 The Author(s). Background: Estrogen receptor-α (ER-α) is a transcriptional regulator, which mediates estrogen-dependent breast development, as well as breast tumorigenesis. The influence of epigenetic regulation of ...
    • Sagredo, Eduardo A.; Blanco, Alejandro; Sagredo, Alfredo I.; Pérez, Paola; Sepúlveda-Hermosilla, Gonzalo; Morales, Fernanda; Müller, Bettina; Verdugo, Ricardo; Marcelain Cubillos, Katherine; Harismendy, Olivier; Armisén, Ricardo (NLM (Medline), 2018)
      RESULTS: We characterized A to G(I) mRNA editing in 81 breast cell lines, showing increased editing at 3'UTR and exonic regions in breast cancer cells compared to immortalized non-malignant cell lines. In addition, tumors ...
    • Rubio Álvarez, Eduardo; Amaro, José; Villavicencio, Leonel (Sociedad Chilena de Infectología, 2018)
      In the last eleven months, we have diagnosed 9 cases of Histoplasmosis in our country. All patients affected were from endemic areas of South-America. Here, we wish to inform and prevent to all clinical laboratories ...
    • Lucero, Yalda; O'Ryan Gallardo, Miguel; Liparoti, Giulia; Huerta, Nicole; Mamani, Nora; Ramani, Sasirekha; Lagomarcino, Anne J.; Del Canto, Felipe; Quense, Jorge (Mosby Inc., 2018)
      © 2018 Elsevier Inc. Rotavirus G8P[8] infection has been common in Africa, but rare in the Americas. Among 23 rotavirus episodes observed during 18 months of surveillance of 100 families in Chile, 11 (48%) were identified ...