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Publicaciones Artículos de revistas por fecha de publicación

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Mostrando registros 1-20 de 858

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    • ArtículoThumbnail
      Protective effect of the flavonoid silybin dihemisuccinate on the toxicity of phenylhydrazine on rat liver 
      Valenzuela Bonomo, Carlos; Guerra, Ricardo (1985)
      Phenylhydrazine is a hemolytic agent whose mechanism of action is related with the formation of free radicals and the induction of lipid peroxidation. The flavonoid silybin dihemisuccinate is an antihepatotoxic principle ...
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      Human chorionic gonadotropin and free beta subunits stimulate phospholipid methylation in intact rat Leydig cells 
      Ronco Macchiavello, Ana María; Llanos Silva, Miguel; Valladares Boasi, Luis (1993)
      The effect of human chorionic gonadotropin (hCG) on intact Leydig cell phospholipid methylation was studied. Hormonal stimulation of rat Leydig cells increased the incorporation of[methyl-3H]methionine into phospholipids ...
    • ArtículoThumbnail
      Bone mineralization in adolescents suffering from postnatal malnutrition 
      Muzzo Benavides, Juan Santiago; Leiva Balich, Laura; Lillo Ganter, Ricardo; Pumarino Carte, Hugo; Ernst, Renata; Burrows, Raquel (1995)
      Bone mineralization of adolescents that suffered of early postnatal u n d ern u tritio n . The bone mineralization o f 6 male and 18 female adolescents with a mean age o f 12 years and 11 months, who had suffered severe, ...
    • ArtículoThumbnail
      Vivienda y pobreza en mujeres jóvenes 
      Álvarez Marín, María de la Luz (Universidad de Chile, 1995)
      Se estudia a familias jóvenes pobres para detectar cual es el grupo más vulnerable respecto a la vivienda. La muestra estuvo formada por 100 familias jóvenes de Peñalolén. Cincuenta de nivel socio económico (NSE) muy bajo ...
    • ArtículoThumbnail
      Soluble factors produced by PC-3 prostate cells decrease collagen content and mineralisation rate in fetal ... 
      Santibañez, J. F. (Stockton Press, 1996)
      Approximately 70% of patients with prostate cancer develop bone metastases in the advanced state of the disease. In the present study, we sought to test the hypothesis that prostatic cancer cells produce factors that ...
    • ArtículoThumbnail
      Prostate-Derived Soluble Factors Block Osteoblast Differentiation in Culture 
      Martínez Winkler, Jorge; Silva, Sofía; Santibáñez, Juan Francisco (WILEY-LISS, DIV JOHN WILEY & SONS INC, 1996-04)
      Bone metastasis is a common event and a major cause of morbidity in prostate cancer patients. After colonization of bone, prostate cells induce an osteoblastic reaction which is not associated with marrow fibrosis ...
    • ArtículoThumbnail
      The compound 14-keto-stypodiol diacetate from the algae Stypopodium flabelliforme inhibits microtubules and ... 
      Depix, María S.; Martínez, Jorge; Santibañez, Francisco; Rovirosa, Juana; San Martín Barrientos, Aurelio; Maccioni Baraona, Ricardo (1998)
      We investigated the effects of the drug 14-keto-stypodiol diacetate (SDA) extracted from the seaweed product Stypopodium flabelliforme, in inhibiting the cell growth and tumor invasive behavior of DU-145 human prostate ...
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      Urokinase Expression and Binding Activity Associated With the Transforming Growth Factor b1-Induced Migratory ... 
      Santibañez, Juan Francisco; Frontelo, Pilar; Iglesias, Maite; Martínez, Jorge; Quintanilla, Miguel (Wiley-Liss, Inc., 1999)
      Transforming growth factor b1(TGF-b1) is a stimulator of malignant progression in mouse skin carcinogenesis. TGF-b1 exerts a differential effect on cultured nontumorigenic (MCA3D cell line) and transformed (PDV cell line) ...
    • ArtículoThumbnail
      BONE EXTRACELLULAR MATRIX STIMULATES INVASIVENESS OF ESTROGEN-RESPONSIVE HUMAN MAMMARY MCF-7 CELLS 
      Martínez Winkler, Jorge; Fuentes, Mauricio; Cambiazo Ayala, Liliana; Santibáñez, J. Francisco (WILEY-LISS, DIV JOHN WILEY & SONS INC, 1999-10-08)
      Bone is the most frequent site of metastasis in breast cancer. This causes destructive osteolytic lesions. To achieve metastasis to bone, breast cancer cells must proliferate in a new microenvironment, arrest on ...
    • ArtículoThumbnail
      Transferrin modulates tumor necrosis factor-α secretion by cultured human mononuclear cells: influence of ... 
      Muñoz, C.; Olivares, M. (2000)
    • ArtículoThumbnail
      Mesenchymal Stem Cells from Osteoporotic Patients Produce a Type I Collagen-Deficient Extracellular Matrix ... 
      Rodríguez, J. Pablo; Montecinos, Luis; Ríos, Susana; Reyes, Patricio; Martínez, Jorge (Wiley-Liss, 2000)
      Mesenchymal stem cells (MSCs), precursor cells resident in the bone marrow, have the capacity to differentiate into bone, cartilage, fat, and connective tissue. We have recently reported that MSCs from "healthy" donors ...
    • ArtículoThumbnail
      Prevalence of anemia in elderly subjects living at home: role of micronutrient deficiency and inflammation 
      Olivares Grohnert, Manuel; Hertrampf, E.; Capurro Spadaro, María Teresa; Wegner, D. (2000-11)
      Objective: Aging is associated with increased risk of developing anemia and micronutrient deficiencies. Wheat-based staple foods are iron fortified in Chile. We aimed to establish the prevalence and etiology of anemia in ...
    • ArtículoThumbnail
      Bone metabolism in children with epidermolysis bullosa 
      Reyes, M. Loreto; Cattani, Andreína; Gajardo, Héctor; García, Cristián; McGrath, John A.; Palisson, Francis (Mosby Elsevier, 2002)
      We evaluated bone mineral density, vitamin D status, and biochemical markers of bone turnover in seven children with epidermolysis bullosa (EB). Four had osteopenia (Z score, -1.5) and four 25(OH) vitamin D <34 nmol/L ...
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      A frameshift insertion in the cone cyclic nucleotide gated cation channel causes complete achromatopsia in ... 
      Rojas, Cecilia V.; Santa María, Lorena; Santos, José Luis; Cortés, Fanny; Alliende, María Angélica (2002)
      Complete achromatopsia is genetically heterogeneous and segregates with mutations in CNGA3 or CNGB3 genes, which respectively encode for α- and β-subunits of the cyclic-nucleotide-gated (CNG) cation channel expressed in ...
    • ArtículoThumbnail
      No Evidence for an Association Between Genetic Polymorphisms of 
      Santos, José Luis; Pérez Bravo, Francisco; Martínez, J. A.; Montalvo, Domingo; Albala Brevis, Cecilia; Carrasco, Elena (Elsevier Science Inc., 2002)
      OBJECTIVE: We assessed the association between Gln27Glu and Trp64Arg genetic polymorphisms of the 2 (ADRB2) and 3 (ADRB3) adrenergic receptor genes with body mass index and other cardiovascular risk factors. METHODS: ...
    • ArtículoThumbnail
      Long-term n-3 FA deficiency modifies peroxisome proliferator-activated receptor beta mRNA abundance in rat ... 
      Rojas Baechler, Cecilia; Greiner, Rebecca S.; Fuenzalida, Lidia C.; Martínez, Jessica I.; Salem, Norman; Uauy Dagach-Imbarack, Ricardo (AMER OIL CHEMISTS SOC A O C S PRESS, 2002-04)
      Peroxisomal proliferator-activated receptors (PPAR) are a FA-response system involved in diverse cellular responses. FA regulate PPAR activity and modulate PPAR mRNA abundance. Increasing evidence indicates that PUFA are ...
    • ArtículoThumbnail
      TGF-L1 and Smad4 overexpression induce a less invasive phenotype in highly invasive spindle carcinoma cells 
      Santibáñez, Juan Francisco; Quintanilla, Miguel; Martínez, Jorge (Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies., 2002-04-18)
      We have examined the effect of transforming growth factor L1 (TGF-L1) and overexpression of the Smad4 gene on the phenotype of Car C, a ras mutated highly malignant spindle carcinoma cell line. TGF-L1-treated Car C cells ...
    • ArtículoThumbnail
      Transforming growth factor-b1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling ... 
      Santibañez, Juan Francisco; Guerrero, Javier; Quintanilla, Miguel; Fabra, Angels; Martínez, Jorge (Elsevier Science (USA), 2002-07-15)
      Mouse transformed keratinocytes cultured in the presence of transforming growth factor-b1 (TGF-b1) acquire a set ofmorphological and functional properties giving rise to a more motile phenotype that expresses mesenchymal ...
    • ArtículoThumbnail
      Suppressive effect of frequent ingestion of Lactobacillus johnsonii La1 on Helicobacter pylori colonization ... 
      Gotteland, Martin; Cruchet, Sylvia (Oxford University Press, 2003)
    • ArtículoThumbnail
      Gene Expression Analysis in Human Fetal Retinal Explants Treated with Docosahexaenoic Acid 
      Rojas Baechler, Cecilia; Martínez, Jessica I.; Flores, Ingrid; Hoffman, Dennis R.; Uauy Dagach-Imbarack, Ricardo (ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2003-07)
      PURPOSE. To explore the effect of docosahexaenoic acid (DHA) on gene expression during human fetal retinal maturation. METHODS. Human fetal retinal explants were cultured in serum-free Waymouth's medium supplemented ...
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