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Autordc.contributor.authorMazariegos, Dora Inés 
Autordc.contributor.authorCabantchik, Z. Ioav es_CL
Autordc.contributor.authorCassels Niven, Brucees_CL
Autordc.contributor.authorNúñez González, Marco es_CL
Fecha ingresodc.date.accessioned2008-12-01T17:08:19Z
Fecha disponibledc.date.available2008-12-01T17:08:19Z
Fecha de publicacióndc.date.issued2006
Cita de ítemdc.identifier.citationBiol Res 39: 199-201, 2006en
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/118744
Resumendc.description.abstractThere is increasing evidence that accumulation of redox-active iron in mitochondria leads to oxidative damage and contributes to various neurodegenerative diseases, such as Friedreich’s ataxia and Parkinson’s disease. In this work, we examined the existence of regulatory mechanisms for mitochondrial iron uptake and storage. To that end, we used rhodamine B-[(1,10-phenanthrolin-5-yl)amino carbonyl] benzyl ester, a new fluorescent iron-sensitive probe that is targeted specifically to the mitochondrion. We found that extracellular iron was incorporated readily into mitochondria in an apparently saturable process. Moreover, the rate of iron incorporation responded to the Fe status of the cell, an indication that the mitochondrion actively regulates its iron content.en
Patrocinadordc.description.sponsorshipThis work was financed by FONDECYT grant 1040448 and ICM grant P99-031.en
Idiomadc.language.isoenen
Palabras clavesdc.subjectMitochondriaen
Títulodc.titleCharacterization of mitochondrial iron uptake in HepG2 cellsen
Tipo de documentodc.typeArtículo de revista


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