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Authordc.contributor.authorMazariegos, Dora Inés 
Authordc.contributor.authorCabantchik, Z. Ioav es_CL
Authordc.contributor.authorCassels Niven, Brucees_CL
Authordc.contributor.authorNúñez González, Marco es_CL
Admission datedc.date.accessioned2008-12-01T17:08:19Z
Available datedc.date.available2008-12-01T17:08:19Z
Publication datedc.date.issued2006
Cita de ítemdc.identifier.citationBiol Res 39: 199-201, 2006en
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/118744
Abstractdc.description.abstractThere is increasing evidence that accumulation of redox-active iron in mitochondria leads to oxidative damage and contributes to various neurodegenerative diseases, such as Friedreich’s ataxia and Parkinson’s disease. In this work, we examined the existence of regulatory mechanisms for mitochondrial iron uptake and storage. To that end, we used rhodamine B-[(1,10-phenanthrolin-5-yl)amino carbonyl] benzyl ester, a new fluorescent iron-sensitive probe that is targeted specifically to the mitochondrion. We found that extracellular iron was incorporated readily into mitochondria in an apparently saturable process. Moreover, the rate of iron incorporation responded to the Fe status of the cell, an indication that the mitochondrion actively regulates its iron content.en
Patrocinadordc.description.sponsorshipThis work was financed by FONDECYT grant 1040448 and ICM grant P99-031.en
Lenguagedc.language.isoenen
Keywordsdc.subjectMitochondriaen
Títulodc.titleCharacterization of mitochondrial iron uptake in HepG2 cellsen
Document typedc.typeArtículo de revista


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