Author | dc.contributor.author | Muñoz, Pablo | |
Author | dc.contributor.author | Zavala, Gabriela | es_CL |
Author | dc.contributor.author | Castillo, Karen | es_CL |
Author | dc.contributor.author | Aguirre, Pabla | es_CL |
Author | dc.contributor.author | Hidalgo Tapia, María Cecilia | es_CL |
Author | dc.contributor.author | Núñez González, Marco | es_CL |
Admission date | dc.date.accessioned | 2008-12-02T10:10:39Z | |
Available date | dc.date.available | 2008-12-02T10:10:39Z | |
Publication date | dc.date.issued | 2006 | |
Cita de ítem | dc.identifier.citation | Biol Res 39: 189-190, 2006 | en |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/118746 | |
Abstract | dc.description.abstract | Recent evidence suggests that reactive oxygen species function as second messenger molecules in normal
physiological processes. For example, activation of N-Methyl-D-Aspartate receptor results in the production
of ROS, which appears to be critical for synaptic plasticity, one of the cellular mechanisms that underlie
learning and memory. In this work, we studied the effect of iron in the activation of MAPK/ERK pathway and
on Ca2+ signaling in neuronal PC12 cells. We found that iron-dependent generation of hydroxyl radicals is
likely to modulate Ca2+ signaling through RyR calcium channel activation, which, in turn, activates the
MAPK/ERK pathway. These findings underline the relevance of iron in normal neuronal function. | en |
Patrocinador | dc.description.sponsorship | This work was supported by grants FONDAP CEMC 15010006, MECESUP UCH001, and ICM P99-031F. | en |
Lenguage | dc.language.iso | en | en |
Keywords | dc.subject | NMDA receptor | en |
Título | dc.title | Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells | en |
Document type | dc.type | Artículo de revista | |