Structure-reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets

Author	dc.contributor.author	Campodónico, Paola R.
Author	dc.contributor.author	Contreras Ramos, Renato	es_CL
Admission date	dc.date.accessioned	2010-01-12T14:56:34Z
Available date	dc.date.available	2010-01-12T14:56:34Z
Publication date	dc.date.issued	2008-03-15
Cita de ítem	dc.identifier.citation	BIOORGANIC & MEDICINAL CHEMISTRY Volume: 16 Issue: 6 Pages: 3184-3190 Published: MAR 15 2008	en_US
Identifier	dc.identifier.issn	0968-0896
Identifier	dc.identifier.other	10.1016/j.bmc.2007.12.018
Identifier	dc.identifier.uri	https://repositorio.uchile.cl/handle/2250/118913
Abstract	dc.description.abstract	The global electrophilicity index that incorporates electrostatic and polarizability contributions shows a quantitative correlation with antiviral and cytotoxic activities of electrophilic sugars. The model is applied to a series of compounds that behave as Michael acceptors in interaction with biological nucleophilic targets.	en_US
Lenguage	dc.language.iso	en	en_US
Publisher	dc.publisher	Pergamon-Elsevier	en_US
Keywords	dc.subject	Density-Functional-Theory	en_US
Título	dc.title	Structure-reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets	en_US
Document type	dc.type	Artículo de revista