| Author | dc.contributor.author | Mendoza Naranjo, Ariadna | |
| Author | dc.contributor.author | González Billault, Christian | es_CL |
| Author | dc.contributor.author | Maccioni Baraona, Ricardo | es_CL |
| Admission date | dc.date.accessioned | 2011-03-23T17:11:33Z | |
| Available date | dc.date.available | 2011-03-23T17:11:33Z | |
| Publication date | dc.date.issued | 2006-10-30 | |
| Cita de ítem | dc.identifier.citation | JOURNAL OF CELL SCIENCE, Volume: 120, Issue: 2, Pages: 279-288, 2007 | en_US |
| Identifier | dc.identifier.issn | 0021-9533 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119105 | |
| Abstract | dc.description.abstract | A number of psychiatric and neurodegenerative disorders,
such as Alzheimer’s disease, are characterized by
abnormalities in the neuronal cytoskeleton. Here, we find
that the enhancement in actin polymerization induced by
fibrillar amyloid-beta peptide (A ) is associated with
increased activity of Rac1/Cdc42 Rho GTPases. Rac1
upregulation involves the participation of Tiam1, a Rac
guanine-nucleotide exchange factor, where A exposure
leads to Tiam1 activation by a Ca2+-dependent mechanism.
These results point to Rho GTPases as one of the targets in
A -induced neurodegeneration in Alzheimer’s disease
pathology, with a role in mediating changes in the actin
cytoskeletal dynamics. | en_US |
| Patrocinador | dc.description.sponsorship | This work was supported by grants from FONDECYT 1050198 to
R.B.M. and by the Millennium Institute CBB. A.M.-N. was supported
by a doctoral fellowship from the Millennium Institute for Advanced
Studies in Cell Biology and Biotechnology (CBB). | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | COMPANY OF BIOLOGISTS LTD | en_US |
| Keywords | dc.subject | Alzheimer’s disease | en_US |
| Título | dc.title | A beta(1-42) stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases | en_US |
| Document type | dc.type | Artículo de revista | |
