| Author | dc.contributor.author | Cavodeassi, Florencia | |
| Author | dc.contributor.author | Carreira-Barbosa, Filipa | es_CL |
| Author | dc.contributor.author | Young, Rodrigo M. | es_CL |
| Author | dc.contributor.author | Concha, Miguel L. | es_CL |
| Author | dc.contributor.author | Allende Connelly, Miguel | es_CL |
| Author | dc.contributor.author | Houart, Corinne | es_CL |
| Author | dc.contributor.author | Tada, Masazumi | es_CL |
| Author | dc.contributor.author | Wilson, Stephen W. | es_CL |
| Admission date | dc.date.accessioned | 2011-03-31T12:12:48Z | |
| Available date | dc.date.available | 2011-03-31T12:12:48Z | |
| Publication date | dc.date.issued | 2005-07-07 | |
| Cita de ítem | dc.identifier.citation | NEURON, Volume: 47, Issue: 1, Pages: 43-56, 2005 | en_US |
| Identifier | dc.identifier.issn | 0896-6273 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119124 | |
| Abstract | dc.description.abstract | During regional patterning of the anterior neural plate, a medially positioned domain of cells is
specified to adopt retinal identity. These eye field cells remain coherent as they undergo
morphogenetic events distinct from other prospective forebrain domains. We show that two branches
of the Wnt signaling pathway coordinate cell fate determination with cell behavior during eye field
formation. Wnt/β-catenin signaling antagonizes eye specification through the activity of Wnt8b and
Fz8a. In contrast, Wnt11 and Fz5 promote eye field development, at least in part, through local
antagonism of Wnt/β-catenin signaling. Additionally, Wnt11 regulates the behavior of eye field cells,
promoting their cohesion. Together, these results allow us to postulate a model in which Wnt11 and
Fz5 signaling promotes early eye development through the coordinated antagonism of signals that
suppress retinal identity and promotion of coherence of eye field cells. | en_US |
| Patrocinador | dc.description.sponsorship | This work was supported by a European Community Marie
Curie Fellowship and a Human Frontiers Program Fellowship to F.C. and by grants from the Wellcome Trust, BBSRC,
and European Community to S.W.W. F.C.B. was supported by Programa Gulbenkian de Doutoramento em Biologia
e Medicina; R.M.Y. was supported by a Fondecyt 2010058 Grant, a Company of Biologists Travel Fellowship, and
a Boehringer Ingelheim Travel Allowance; M.L.A. is funded by FONDECYT Chile (1020902) and Wellcome Trust;
M.L.A. was supported by Fondecyt 1031003, ICM P02-050, ICGEB; M.T. had a Career Development Fellowship of
the MRC; and S.W.W. was a Wellcome Trust Senior Research Fellow. | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | CELL PRESS | en_US |
| Keywords | dc.subject | CONVERGENT EXTENSION MOVEMENTS | en_US |
| Título | dc.title | Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway | en_US |
| Document type | dc.type | Artículo de revista | |
