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Authordc.contributor.authorSekler, Alejandra 
Authordc.contributor.authorJiménez, José M. es_CL
Authordc.contributor.authorRojo, Leonel es_CL
Authordc.contributor.authorPastene, Edgard es_CL
Authordc.contributor.authorFuentes, Patricio es_CL
Authordc.contributor.authorSlachevsky Chonchol, Andrea es_CL
Authordc.contributor.authorMaccioni Baraona, Ricardo es_CL
Admission datedc.date.accessioned2011-04-07T11:11:32Z
Available datedc.date.available2011-04-07T11:11:32Z
Publication datedc.date.issued2008
Cita de ítemdc.identifier.citationNeuropsychiatric Disease and Treatment, 2008:4( 4) 715-722en_US
Identifierdc.identifier.issn1178-2021
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/119152
Abstractdc.description.abstractOxidative stress has be en implicated in the progression of a number of neurodegenerative diseases, inc1uding Alzheimer's disease (AD), Parkinson's disease and amyotrophic lateral sclerosis. We carried out a~ in-depth study of cognitive impainnent and its relationships with oxidative stress markers such as ferric-reducing ability of plasma (FRAP), plasma malondialdehyde and total antioxidative capacity (T AC), as well as cholesterol parameters, in two subsets ofsubjects, AD patients (n = 59) and a control group ofneurologically normal subjects (n = 29), attending thc University Hospital Salvador in Santiago, Chile. Cognitivc impairment was assessed by a sct of neuropsychological tests (Mini-Mental State Examination, Boston Naming Test, Ideomotor Praxia by imitatíoll, Semantic Verbal Fluency of animals or words with initial A, Test ofMcmory Alteration, Frontal Asscssmcnt Battcry), whilc the levels ofthose oxidative stress markers and cholesterol metabolism parameters were determined according with standard bioassays in fresh plasma samples of the two subgroups of patients. No significant differences were observed when the cholesterol parameters (low-, high-density lipoprotein, total cholesterol) of the AD group were compared with normal controls. Interestingly, a correlation was evidenced when the levels of cognitive impairment were analyzed with respect to the plasma antioxidant capacity (AOC) ofpatients. In this context, the subset of subjects exhibiting cognitive impairment were divided into two subgroups according with their Global Dementia Scale performance: a subgroup with mild AD and a subgroup with moderate to severc AD. Significant differences in AOC were found between subgroups. The different correlations between cognitive impainnent of subgroups of subjects with the oxidative stress profilc are discussed in the context of AD pathogenesis.en_US
Patrocinadordc.description.sponsorshipResearch was supported by grants 1050198 and 1080254 from FONDECYT, the International Center for Biomedicine (to RBM) and by the Bicentennial Project IPC-79 of PBCT -CONICYT (to AS). The authors report no conflicts of interest in this work.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherBioMed Centralen_US
Keywordsdc.subjectoxidative stressen_US
Títulodc.titleCognitive impairment and Alzheimer's disease: Links with oxidative stress and cholesterol metabolismen_US
Document typedc.typeArtículo de revista


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