Author | dc.contributor.author | Lisbona, Fernanda | |
Author | dc.contributor.author | Rojas Rivera, Diego | es_CL |
Author | dc.contributor.author | Thielen, Peter | es_CL |
Author | dc.contributor.author | Zamorano, Sebastián | es_CL |
Author | dc.contributor.author | Todd, Derrick | es_CL |
Author | dc.contributor.author | Martinon, Fabio | es_CL |
Author | dc.contributor.author | Glavic Maurer, Álvaro | es_CL |
Author | dc.contributor.author | Kress, Christina | es_CL |
Author | dc.contributor.author | Lin, Jonathan H. | es_CL |
Author | dc.contributor.author | Walter, Peter | es_CL |
Author | dc.contributor.author | Reed, John C. | es_CL |
Author | dc.contributor.author | Glimcher, Laurie H. | es_CL |
Author | dc.contributor.author | Hetz Flores, Claudio | es_CL |
Admission date | dc.date.accessioned | 2011-04-25T16:41:40Z | |
Available date | dc.date.available | 2011-04-25T16:41:40Z | |
Publication date | dc.date.issued | 2009-03-27 | |
Cita de ítem | dc.identifier.citation | MOLECULAR CELL, Volume: 33, Issue: 6, Pages: 679-691, 2009 | es_CL |
Identifier | dc.identifier.issn | 1097-2765 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119179 | |
Abstract | dc.description.abstract | Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal
transduction pathway known as the unfolded protein response (UPR). Bax inhibitor-1 (BI-1) is an
evolutionarily conserved ER-resident protein that suppresses cell death. Here we have investigated
the role of BI-1 in the UPR. BI-1 expression suppressed IRE1α activity in fly and mouse models
of ER stress. BI-1 deficient cells displayed hyperactivation of the ER stress sensor IRE1α, leading
to increased levels of its downstream target X-Box binding protein-1 (XBP-1) and upregulation of
UPR target genes. This phenotype was associated with the formation of a stable protein complex
between BI-1 and IRE1α, decreasing its ribonuclease activity. Finally, BI-1 deficiency increased
the secretory activity of primary B cells, a phenomenon regulated by XBP-1. Our results suggest a
new role for BI-1 in early adaptive responses against ER stress which contrasts with its known
downstream function in apoptosis. | es_CL |
Patrocinador | dc.description.sponsorship | Funding Agency Grant Number
V. Harold and Leila Y. Mathers Charitable Foundation
NIHA132412
FONDECYT
1070444
FONDAP
15010006
Millennium Nucleus
P07-048-F
Muscular Dystrophy Association
Michael J. Fox Foundation for Parkinson's Research, National Parkinson's Disease
High Q Foundation
ICM P06-039
AI-15353
National Institutes of Health and the U.S. Department of Defense | es_CL |
Lenguage | dc.language.iso | en | es_CL |
Publisher | dc.publisher | CELL PRESS | es_CL |
Keywords | dc.subject | UNFOLDED PROTEIN RESPONSE | es_CL |
Título | dc.title | BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1 alpha | es_CL |
Document type | dc.type | Artículo de revista | |