| Author | dc.contributor.author | Molina Salinas, Gloria María | |
| Author | dc.contributor.author | Bórquez, Jorge | es_CL |
| Author | dc.contributor.author | Ardiles, Alejandro | es_CL |
| Author | dc.contributor.author | Said Fernández, Salvador | es_CL |
| Author | dc.contributor.author | Loyola, Luis Alberto | es_CL |
| Author | dc.contributor.author | Yam Puc, Alejandro | es_CL |
| Author | dc.contributor.author | Becerril Montes, Pola | es_CL |
| Author | dc.contributor.author | Escalante Erosa, Fabiola | es_CL |
| Author | dc.contributor.author | San Martín Barrientos, Aurelio | es_CL |
| Author | dc.contributor.author | González Collado, Isidro | es_CL |
| Author | dc.contributor.author | Peña Rodríguez, Luis Manuel | es_CL |
| Admission date | dc.date.accessioned | 2011-08-24T13:04:18Z | |
| Available date | dc.date.available | 2011-08-24T13:04:18Z | |
| Publication date | dc.date.issued | 2010-02-17 | |
| Cita de ítem | dc.identifier.citation | PHYTOCHEMISTRY REVIEWS, Volume: 9, Issue: 2, Special Issue: SI, Pages: 271-278, 2010 | es_CL |
| Identifier | dc.identifier.issn | 1568-7767 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119268 | |
| General note | dc.description | Artículo de publicación ISI. | es_CL |
| Abstract | dc.description.abstract | Natural products are recognized as an
important source of new and better pharmaceuticals
for the treatment of diseases such as tuberculosis. The
azorellane and mulinane diterpenoids represent an
interesting group of bioactive metabolites produced
by Andean plants belonging to the Azorella, Mulinum,
Laretia and Bolax genus. Testing of natural and
semisynthetic azorellanes and mulinanes against two
Mycobacterium tuberculosis strains showed that
while most changes in the structure of the natural
metabolites result in the loss of antituberculosis
activity, methylation of the C-20 carboxyl group
improves the biological activity of the corresponding
derivatives. | es_CL |
| Patrocinador | dc.description.sponsorship | LAL wishes to
acknowledge FONDECYT-Chile support for this project (Grant
No. 1060339). The evaluation of antituberculosis activity in this
collaborative work was supported by Instituto Mexicano del
Seguro Social (Project 2008-1908-4). Research was performed
under the auspices of the EULADIV Alfa Project, FOMIXYucata
´n Project No. 66262 and Programa de Cooperacio´n
Bilateral Mexico-Chile. | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | SPRINGER | es_CL |
| Keywords | dc.subject | Apiaceae | es_CL |
| Título | dc.title | Bioactive metabolites from the Andean flora. Antituberculosis activity of natural and semisynthetic azorellane and mulinane diterpenoids | es_CL |
| Document type | dc.type | Artículo de revista | |
