Author | dc.contributor.author | Sarrazín, Andrés F. | |
Author | dc.contributor.author | Núñez, Viviana A. | es_CL |
Author | dc.contributor.author | Sapède, Dora | es_CL |
Author | dc.contributor.author | Tassin, Valériane | es_CL |
Author | dc.contributor.author | Dambly-Chaudiere, Christine | es_CL |
Author | dc.contributor.author | Ghysen, Alain | es_CL |
Admission date | dc.date.accessioned | 2011-09-13T18:46:09Z | |
Available date | dc.date.available | 2011-09-13T18:46:09Z | |
Publication date | dc.date.issued | 2010-01-11 | |
Cita de ítem | dc.identifier.citation | JOURNAL OF NEUROSCIENCE, Volume: 30, Issue: 24, Pages: 8234-8244, 2010 | es_CL |
Identifier | dc.identifier.issn | 0270-6474 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119295 | |
General note | dc.description | Artículo de publicación ISI | es_CL |
Abstract | dc.description.abstract | The lateral line system of teleosts has recently become a model system to study patterning and morphogenesis. However, its embryonic
origins are still not well understood. In zebrafish, the posterior lateral line (PLL) system is formed in two waves, one that generates the
embryonic line of seven to eight neuromasts and 20 afferent neurons and a second one that generates three additional lines during larval
development. The embryonic line originates from a postotic placode that produces both a migrating sensory primordium and afferent
neurons. Nothing is known about the origin and innervation of the larval lines. Here we show that a “secondary” placode can be detected
at 24 h postfertilization (hpf), shortly after the primary placode has given rise to the embryonic primordium and ganglion. The secondary
placode generates two additional sensory primordia, primD and primII, as well as afferent neurons. The primary and secondary placodes
require retinoic acid signaling at the same stage of late gastrulation, suggesting that they share a common origin. Neither primary nor
secondary neurons show intrinsic specificity for neuromasts derived from their own placode, but the sequence of neuromast deposition
ensures that neuromasts are primarily innervated by neurons derived from the cognate placode. The delayed formation of secondary
afferent neurons accounts for the capability of the fish to form a new PLL ganglion after ablation of the embryonic ganglion at 24 hpf. | es_CL |
Patrocinador | dc.description.sponsorship | This work was supported by the Agence Nationale pour la Recherche, by the Association pour la Recherche sur le
Cancer, and by a cooperation grant between the Comisión Nacional de Investigación Científica y Tecnológica (CONICYT,
Chile) and the Comité Evaluation de la Coopération Scientifique (ECOS-Sud, France). We thank M. Bronner-
Fraser for expert editorial assistance; R. Ladher, C. Baker, and G. Schlosser for helpful discussions about placodes; V.
McCabe for comments on this manuscript; and two anonymous reviewers for their stimulating comments. N.
Cubedo provided excellent fish care. | es_CL |
Lenguage | dc.language.iso | en | es_CL |
Publisher | dc.publisher | SOC NEUROSCIENCE | es_CL |
Keywords | dc.subject | RETINOIC ACID | es_CL |
Título | dc.title | Origin and Early Development of the Posterior Lateral Line System of Zebrafish | es_CL |
Document type | dc.type | Artículo de revista | |