| Author | dc.contributor.author | Gómez Jeria, Juan | |
| Author | dc.contributor.author | Lagos Arancibia, Luis | es_CL |
| Admission date | dc.date.accessioned | 2011-10-11T18:44:35Z | |
| Available date | dc.date.available | 2011-10-11T18:44:35Z | |
| Publication date | dc.date.issued | 1998-09-28 | |
| Cita de ítem | dc.identifier.citation | INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Volume: 71, Issue: 6, Pages: 505-511, 1999 | es_CL |
| Identifier | dc.identifier.issn | 0020-7608 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119326 | |
| General note | dc.description | Artículo de publicación ISI | es_CL |
| Abstract | dc.description.abstract | A quantum-chemical structure]affinity relationship for kynurenic acid
derivatives KA. acting at the GlyrNMDA site is presented. The results of this study
strongly suggest that these molecules bind to this site through three mechanisms: 1. a H
bond between the N atom and an OH group of the receptor; 2. a p]p orbital interaction
between the empty MOs of the aromatic ring of KA derivatives and occupied MOs of the
receptor; and 3. an orbital interaction between the carboxylate group and an electronaccepting
site of the receptor. | es_CL |
| Patrocinador | dc.description.sponsorship | We are grateful to Dr. Camilo Quezada, Dean of
the Faculty of Sciences of the University of Chile,
for financial help. | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | John Wiley & Sons, Inc. | es_CL |
| Keywords | dc.subject | D-ASPARTATE RECEPTOR | es_CL |
| Título | dc.title | Quantum-chemical structure-affinity studies on kynurenic acid derivatives as Gly/NMDA receptor ligands | es_CL |
| Document type | dc.type | Artículo de revista | |
