| Author | dc.contributor.author | Liberto, Melina Di | |
| Author | dc.contributor.author | Svetaz, Laura | es_CL |
| Author | dc.contributor.author | Furlán, Ricardo L. E. | es_CL |
| Author | dc.contributor.author | Zacchino, Susana | es_CL |
| Author | dc.contributor.author | Delporte Vergara, Carla | es_CL |
| Author | dc.contributor.author | Novoa, Marco A. | es_CL |
| Author | dc.contributor.author | Asencio, Marcelo | es_CL |
| Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
| Admission date | dc.date.accessioned | 2012-05-18T15:03:02Z | |
| Available date | dc.date.available | 2012-05-18T15:03:02Z | |
| Publication date | dc.date.issued | 2010-05-20 | |
| Cita de ítem | dc.identifier.citation | NPC Natural Product Communications, vol. 5, nº 7, p.993-1160, 2010 | es_CL |
| Identifier | dc.identifier.issn | 1555-9475 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119398 | |
| Abstract | dc.description.abstract | A saponin-rich extract of Phytolacca dioica L. berries, its acid hydrolysate, and its major aglycone, phytolaccagenin, were
assayed for antifungal activity against ATCC standard cultures of Candida albicans and Cryptococcus neoformans, and against
clinical isolates of these fungi. The activity of the extract was either low or negligible, but the hydrolysate, containing the
sapogenins, including phytolaccagenin, and also pure phytolaccagenin, showed promising antifungal potency. Hydrolysis of a
natural product extract is shown to be a useful modification leading to improved bioactivity. | es_CL |
| Patrocinador | dc.description.sponsorship | This work was funded by grants
from FONDECYT (Chile) 1080174, ICM (Chile) P05-
001-F, ANPCyT (Argentina) PICT995, and UNR
(Argentina) BIO 133. | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | EDITORIAL BOARD | es_CL |
| Keywords | dc.subject | Saponins | es_CL |
| Título | dc.title | Antifungal Activity of Saponin-rich Extracts of Phytolacca dioica and of the Sapogenins Obtained through Hydrolysis | es_CL |
| Document type | dc.type | Artículo de revista | |
