Show simple item record

Authordc.contributor.authorAraya Maturana, Ramiro 
Authordc.contributor.authorCardona, Wilson es_CL
Authordc.contributor.authorCassels Niven, Brucees_CL
Authordc.contributor.authorDelgado Castro, Tomás es_CL
Authordc.contributor.authorFerrada Parker, Jorge es_CL
Authordc.contributor.authorMiranda, Dante es_CL
Authordc.contributor.authorPavani, Mario es_CL
Authordc.contributor.authorPessoa Mahana, Hernán es_CL
Authordc.contributor.authorSoto Delgado, Jorge es_CL
Authordc.contributor.authorWeiss López, Boris es_CL
Admission datedc.date.accessioned2012-05-18T19:22:12Z
Available datedc.date.available2012-05-18T19:22:12Z
Publication datedc.date.issued2006-02-28
Cita de ítemdc.identifier.citationBioorganic & Medicinal Chemistry 14: 4664–4669, 2006.es_CL
Identifierdc.identifier.issn0968-0896
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/119406
Abstractdc.description.abstractAbstract—A series of tricyclic hydroquinones, incorporating a carbonyl group in the ortho position relative to the phenol function, were tested as inhibitors of oxygen uptake against the TA3 mouse carcinoma cell line and its multidrug-resistant variant TA3-MTX-R. The title compound, which proved to be the most active one, also exhibited low micromolar dose-dependent growth inhibition of the human tumor U937 cell line (human monocytic leukemia). A tentative structure–activity relationship is proposed for these substances. A comparison between the cytotoxicities of the title compound and 4,4-dimethyl-5,8-dihydroxynaphthalene-1- one, with their activities as inhibitors of oxygen uptake by the TA3-MTX-R cell line, is presented. Also, the inhibition of oxygen uptake by 6-(4-methylpent-3-enyl)-1,4-naphthoquinone was determined and compared with its reported cytotoxicity toward P-388 (murine lymphocytic leukemia), A-549 (human lung carcinoma), HT-29 (human colon carcinoma), and MEL-28 (human melanoma) cells. The inhibition of oxygen uptake by TA3-MTX-R cells is useful as a quick test for preliminary screening of possible anticancer activity.es_CL
Patrocinadordc.description.sponsorshipThis work was supported by FONDECYT Grant Nos. 1000859 and 1030916. W.C. thanks the DAAD for a fellowship.es_CL
Lenguagedc.language.isoenes_CL
Publisherdc.publisherElsevier Ltd.es_CL
Keywordsdc.subjectHydroquinoneses_CL
Títulodc.titleEffects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4H)-anthracenone derivatives on tumor cell respirationes_CL
Document typedc.typeArtículo de revista


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record