| Author | dc.contributor.author | Contreras Vallejos, Erick | |
| Author | dc.contributor.author | Utreras Puratich, Elías | es_CL |
| Author | dc.contributor.author | González Billault, Christian | es_CL |
| Admission date | dc.date.accessioned | 2012-05-29T19:05:35Z | |
| Available date | dc.date.available | 2012-05-29T19:05:35Z | |
| Publication date | dc.date.issued | 2012 | |
| Cita de ítem | dc.identifier.citation | Cellular Signalling 24 (2012) 44–52 | es_CL |
| Identifier | dc.identifier.other | doi:10.1016/j.cellsig.2011.08.022 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119429 | |
| Abstract | dc.description.abstract | Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is mostly active in the
nervous system, where it regulates several processes such as neuronal migration, actin and microtubule dynamics,
axonal guidance, and synaptic plasticity, among other processes. In addition to these known functions,
in the past few years, novel roles for Cdk5 outside of the nervous system have been proposed. These
include roles in gene transcription, vesicular transport, apoptosis, cell adhesion, and migration in many cell
types and tissues such as pancreatic cells, muscle cells, neutrophils, and others. In this review, we will summarize
the recently studied non-neuronal functions of Cdk5, with a thorough analysis of the biological consequences
of these novel roles. | es_CL |
| Patrocinador | dc.description.sponsorship | This work was supported
by Fondecyt 1089095 and ICM P05-001-F (to CG-B). | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | Elsevier | es_CL |
| Keywords | dc.subject | Cdk5 | es_CL |
| Título | dc.title | Going out of the brain: Non-nervous system physiological and pathological functions of Cdk5 | es_CL |
| Document type | dc.type | Artículo de revista | |
