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Authordc.contributor.authorHurtado Guzmán, Claudio 
Authordc.contributor.authorFierro, Angélica es_CL
Authordc.contributor.authorIturriaga-Vásquez, Patricio es_CL
Authordc.contributor.authorSepúlveda Boza, Silvia es_CL
Authordc.contributor.authorCassels Niven, Bruce es_CL
Authordc.contributor.authorReyes Parada, Miguel es_CL
Admission datedc.date.accessioned2012-06-04T19:43:02Z
Available datedc.date.available2012-06-04T19:43:02Z
Publication datedc.date.issued2003-03-10
Cita de ítemdc.identifier.citationJournal of Enzyme Inhibition and Medicinal Chemistry, Vol. 18 (4), p. 339–347, 2003es_CL
Identifierdc.identifier.issn1475-6374
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/119450
Abstractdc.description.abstract(6)-4-Methylthioamphetamine (MTA) was resolved into its enantiomers, and a series of N-alkyl derivatives of the parent compound, as well as its a-ethyl analogue, were prepared. The monoamine oxidase (MAO) inhibitory properties of these substances were evaluated in vitro, using a crude rat brain mitochondrial suspension as the source of enzyme. All compounds produced a selective, reversible and concentration-related inhibition of MAO-A. (1)-MTA proved to be the most potent inhibitor studied, while all the other derivatives were less active than the parent compound, with (2)-MTA being about 18 times less potent than the (1) isomer. The analysis of structure–activity relationships indicates that the introduction of alkyl substituents on the amino group of MTA leads to a reduction in the potency of the derivatives as MAO-A inhibitors, an effect which increases with the size of the substituent.es_CL
Patrocinadordc.description.sponsorshipThis work was supported by the Presidential Chair in Science (BKC, 1996), ICM grant N8 P99-031-F, FONDECYT grant N8 1000776 and DICYT grant N8 029901RP.es_CL
Lenguagedc.language.isoenes_CL
Publisherdc.publisherTaylor & Francis Ltdes_CL
Keywordsdc.subjectMonoamine oxidasees_CL
Títulodc.titleMonoamine Oxidase Inhibitory Properties of Optical Isomers and N-substituted Derivatives of 4-methylthioamphetaminees_CL
Document typedc.typeArtículo de revistaes_CL


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