| Author | dc.contributor.author | Backhouse Erazo, Nadine | |
| Author | dc.contributor.author | Delporte Vergara, Carla | es_CL |
| Author | dc.contributor.author | Givernau, M. | es_CL |
| Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
| Author | dc.contributor.author | Valenzuela, A. | es_CL |
| Author | dc.contributor.author | Speisky Cosoy, Hernán | es_CL |
| Admission date | dc.date.accessioned | 2012-07-24T13:50:53Z | |
| Available date | dc.date.available | 2012-07-24T13:50:53Z | |
| Publication date | dc.date.issued | 1994-03-02 | |
| Cita de ítem | dc.identifier.citation | Agents Actions, Vol. 42, p. 114-117, 1994. | es_CL |
| Identifier | dc.identifier.issn | 0065-4299 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119522 | |
| Abstract | dc.description.abstract | Boldine, an antioxidant alkaloid isolated from
Peumus boldus, exhibits a dose-dependent anti-inflammatory
activity in the carrageenan-induced guinea pig paw
edema test with an oral EDso of 34 mg/kg. Boldine also
reduces bacterial pyrogen-induced hyperthermia in rabbits
to an extent which varied between 51% and 98% at
a dose of 60 mg/kg p.o. In vitro studies carried out in rat
aortal rings revealed that boldine is an effective inhibitor
of prostaglandin biosynthesis, promoting 53% inhibition
at 75 uM. The latter in vitro effect may be mechanistically
linked to the anti-inflammatory and antipyretic effects of
boldine exerted in vivo. | es_CL |
| Patrocinador | dc.description.sponsorship | This work was supported by FONDECYT
Grant No. 1047-91, University of Chile (DTI) Grant No.
Q 2945-9355 and International Foundation for Science Grant No.
F/1494-2. | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | Birkhäuser Verlag | es_CL |
| Keywords | dc.subject | Inflammation | es_CL |
| Título | dc.title | Anti-inflarnrnatory and antipyretic effects of boldine | es_CL |
| Document type | dc.type | Artículo de revista | |
