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Autordc.contributor.authorGotteland, Martín 
Autordc.contributor.authorJiménez, Inés es_CL
Autordc.contributor.authorBrunser, Oscar es_CL
Autordc.contributor.authorGuzmán, Leda es_CL
Autordc.contributor.authorRomero, Sergio es_CL
Autordc.contributor.authorCassels Niven, Brucees_CL
Autordc.contributor.authorSpeisky Cosoy, Hernán es_CL
Fecha ingresodc.date.accessioned2012-08-09T21:32:21Z
Fecha disponibledc.date.available2012-08-09T21:32:21Z
Fecha de publicacióndc.date.issued1996-11-23
Cita de ítemdc.identifier.citationPlanta Medica, 63, p. 311-315, 1997.es_CL
Identificadordc.identifier.issn0032-0943
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/119549
Resumendc.description.abstractThe cytoprotective and anti-inflammatory effects of boldine in an experimental model of acute colitis are reported. The administration of boldine to animals with colitis induced by the intrarectal administration of acetic acid, was found to prot«t against colonic damage as expressed by major reductions in the extent of cell death. tissue disorganization, and edema. Boldine also reduced the colonic neutrophil infiltration, as measured by the myeloperoxidase activity. but it did not significantly affect tissue lipoperoxides. Boldine was found to preserve the colonic f1uidtransporto a function otherwise markedly affected in the tissue of acid-treated animals. Results presented here provide experimental evidence supporting new cytoprotective and antiinflammatory properties of boldine.es_CL
Patrocinadordc.description.sponsorshipThis work was supported in part by Fondecyt, Grant * 1950258.es_CL
Idiomadc.language.isoenes_CL
Publicadordc.publisherGeorg Thiemees_CL
Palabras clavesdc.subjectPeumus bolduses_CL
Títulodc.titleProtective Effect of Boldine in Experimental Colitises_CL
Tipo de documentodc.typeArtículo de revista


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