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Protective Effect of Boldine in Experimental Colitis
Autor | dc.contributor.author | Gotteland, Martín | |
Autor | dc.contributor.author | Jiménez, Inés | es_CL |
Autor | dc.contributor.author | Brunser, Oscar | es_CL |
Autor | dc.contributor.author | Guzmán, Leda | es_CL |
Autor | dc.contributor.author | Romero, Sergio | es_CL |
Autor | dc.contributor.author | Cassels Niven, Bruce | es_CL |
Autor | dc.contributor.author | Speisky Cosoy, Hernán | es_CL |
Fecha ingreso | dc.date.accessioned | 2012-08-09T21:32:21Z | |
Fecha disponible | dc.date.available | 2012-08-09T21:32:21Z | |
Fecha de publicación | dc.date.issued | 1996-11-23 | |
Cita de ítem | dc.identifier.citation | Planta Medica, 63, p. 311-315, 1997. | es_CL |
Identificador | dc.identifier.issn | 0032-0943 | |
Identificador | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119549 | |
Resumen | dc.description.abstract | The cytoprotective and anti-inflammatory effects of boldine in an experimental model of acute colitis are reported. The administration of boldine to animals with colitis induced by the intrarectal administration of acetic acid, was found to prot«t against colonic damage as expressed by major reductions in the extent of cell death. tissue disorganization, and edema. Boldine also reduced the colonic neutrophil infiltration, as measured by the myeloperoxidase activity. but it did not significantly affect tissue lipoperoxides. Boldine was found to preserve the colonic f1uidtransporto a function otherwise markedly affected in the tissue of acid-treated animals. Results presented here provide experimental evidence supporting new cytoprotective and antiinflammatory properties of boldine. | es_CL |
Patrocinador | dc.description.sponsorship | This work was supported in part by Fondecyt, Grant * 1950258. | es_CL |
Idioma | dc.language.iso | en | es_CL |
Publicador | dc.publisher | Georg Thieme | es_CL |
Palabras claves | dc.subject | Peumus boldus | es_CL |
Título | dc.title | Protective Effect of Boldine in Experimental Colitis | es_CL |
Tipo de documento | dc.type | Artículo de revista |
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