Author | dc.contributor.author | Gotteland, Martín | |
Author | dc.contributor.author | Jiménez, Inés | es_CL |
Author | dc.contributor.author | Brunser, Oscar | es_CL |
Author | dc.contributor.author | Guzmán, Leda | es_CL |
Author | dc.contributor.author | Romero, Sergio | es_CL |
Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
Author | dc.contributor.author | Speisky Cosoy, Hernán | es_CL |
Admission date | dc.date.accessioned | 2012-08-09T21:32:21Z | |
Available date | dc.date.available | 2012-08-09T21:32:21Z | |
Publication date | dc.date.issued | 1996-11-23 | |
Cita de ítem | dc.identifier.citation | Planta Medica, 63, p. 311-315, 1997. | es_CL |
Identifier | dc.identifier.issn | 0032-0943 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119549 | |
Abstract | dc.description.abstract | The cytoprotective and anti-inflammatory effects of
boldine in an experimental model of acute colitis are reported.
The administration of boldine to animals with colitis induced by
the intrarectal administration of acetic acid, was found to prot«t
against colonic damage as expressed by major reductions in the
extent of cell death. tissue disorganization, and edema. Boldine
also reduced the colonic neutrophil infiltration, as measured by
the myeloperoxidase activity. but it did not significantly affect
tissue lipoperoxides. Boldine was found to preserve the colonic
f1uidtransporto a function otherwise markedly affected in the
tissue of acid-treated animals. Results presented here provide
experimental evidence supporting new cytoprotective and antiinflammatory
properties of boldine. | es_CL |
Patrocinador | dc.description.sponsorship | This work was supported in part by Fondecyt, Grant *
1950258. | es_CL |
Lenguage | dc.language.iso | en | es_CL |
Publisher | dc.publisher | Georg Thieme | es_CL |
Keywords | dc.subject | Peumus boldus | es_CL |
Título | dc.title | Protective Effect of Boldine in Experimental Colitis | es_CL |
Document type | dc.type | Artículo de revista | |