Author | dc.contributor.author | Lobos, Mauricio | |
Author | dc.contributor.author | Borges, Yolanda | es_CL |
Author | dc.contributor.author | González, Ernesto | es_CL |
Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
Admission date | dc.date.accessioned | 2012-08-22T16:18:54Z | |
Available date | dc.date.available | 2012-08-22T16:18:54Z | |
Publication date | dc.date.issued | 1992-03-26 | |
Cita de ítem | dc.identifier.citation | Gen. Pharmac., Vol. 23, No. 6, pp. 1139-1142, 1992. | es_CL |
Identifier | dc.identifier.issn | 0306-3623 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119554 | |
Abstract | dc.description.abstract | 1. 2C-B [2-(4-bromo-2,5-dimethoxyphenyl)ethylamine] elicits concentration-dependent contraetion
of the rat thoracic aorta (apparent pD2 = 4.55). The maximal contraction (Emax) attained wíth 2C-B is
less than that produced by either norepinephrine (NE) or serotonin (5-HT).
2. Pretreatment wíth either prazosin (5 x 10-9-10-8 M) or ketanserin (5 x 10-9_10-8 M) leads to
decreased slopes and Emax in the 2C-B dose-response curves.
3. 2.82 x 10-5M 2C-B potentiates the response to low concentrations of NE; 5 x 10-5M 2C-B shows
similar behaviour, but wíth reduced Emax• At 10-6 M 2C-B acts as a competitive 5-HT antagonist; at
2.8 x 10-5 M, however, it behaves like a non-competitive 5-HT antagonist.
4. Removal of the endotheliallining from the aortal rings on1y shifts the 2C-B dose-response curve to the
left.
5. These results suggest that 2C-B behaves as a partial agonist toward both cxl-adrenergíc and 5-HT2
serotonergíc receptors. The endothelium only seems to act as a diffusional barrier to the drug. | es_CL |
Patrocinador | dc.description.sponsorship | This work was supported by FONDECYT
Grant 915-89. | es_CL |
Lenguage | dc.language.iso | en | es_CL |
Publisher | dc.publisher | Pergamon Press Ltd. | es_CL |
Título | dc.title | THE ACTION OF THE PSYCHOACTIVE DRUG 2C-B ON ISOLATED RAT THORACIC AORTA | es_CL |
Document type | dc.type | Artículo de revista | |