| Author | dc.contributor.author | Gómez Jeria, Juan | |
| Author | dc.contributor.author | Morales Lagos, Demian | es_CL |
| Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
| Author | dc.contributor.author | Saavedra Aguilar, Juan Carlos | es_CL |
| Admission date | dc.date.accessioned | 2012-08-22T16:19:17Z | |
| Available date | dc.date.available | 2012-08-22T16:19:17Z | |
| Publication date | dc.date.issued | 1986 | |
| Cita de ítem | dc.identifier.citation | Quant. Struct.-Act. Relat, Vol. 5, p. 153 - 157, 1986. | es_CL |
| Identifier | dc.identifier.issn | 0722 - 3676 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119557 | |
| Abstract | dc.description.abstract | A QSAR study was carried out seeking a relationship
between the receptor binding affinities and the molecularelectronic
structures of a group of 7-substituted tryptamines.
Tbe results suggest that these molecules interact with the
rat stomach fundus serotonergic receptor by charge transfer
from the aromatic nucleus and that there are pockets in the
receptor whiCh place limits on the sizes of acceptable N-and
cx.-carbon substituents. AIso, the charge density available at
carbon atom 7 and the size of the C-7 substituent 'as estimated
by a calculated steric factor seem to make important
contributions to an optimal interaction between the IAA
and the receptor molecules. | es_CL |
| Patrocinador | dc.description.sponsorship | This work has received financial support from the University
of Chile (DIB Project Q-2442), and from tbe Fondo
Nacional de Ciencia (Project 1075). | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | QSAR World | es_CL |
| Keywords | dc.subject | Quantitative structure-activity relationships | es_CL |
| Título | dc.title | Electronic Structure and Serotonin Receptor Binding Affinity of 7-Substituted Tryptamines QSAR of 7-Substituted Tryptamines | es_CL |
| Document type | dc.type | Artículo de revista | |
