Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi
Author | dc.contributor.author | Morello Casté, Antonio | |
Author | dc.contributor.author | Lipchenca, I. | es_CL |
Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
Author | dc.contributor.author | Speisky Cosoy, Hernán | es_CL |
Author | dc.contributor.author | Aldunate, J. | es_CL |
Author | dc.contributor.author | Repetto Scaramelli, Yolanda | es_CL |
Admission date | dc.date.accessioned | 2012-08-22T16:18:38Z | |
Available date | dc.date.available | 2012-08-22T16:18:38Z | |
Publication date | dc.date.issued | 1993-11-01 | |
Cita de ítem | dc.identifier.citation | Comp. Biochem. Physiof. Vol. 107C, No. 3, p. 367-371, 1994 | es_CL |
Identifier | dc.identifier.issn | 0742-8413 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119560 | |
Abstract | dc.description.abstract | The alkaloids boldine, glaucine, predicentrine, apomorphine, coclaurine, norarmepavine and codeine were tested against the epimastigotes of the Tulahuén and LQ strains and the DM 28c clone of Trypanosoma cruzi. The micromolar concentration to inhibit 50% of the culture growth (Tulahuén strain) for apomorphine, glaucine, predicentrine, boldine, norarmepavine, coclaurine and codeine were 29, 90, 85, 110, 310, 580 and > 1000 respectively. Similar values were obtained with theLQ strain and the DM 28c clone. The most active compounds in inhibiting culture growth also inhibited cell respiration, suggesting that these drugs may act by blocking mitochondrial electron transporto The trypanocidal effects of these alkaloids appear to be correlated with their antioxidative activities. | es_CL |
Patrocinador | dc.description.sponsorship | This research was supported by FONDECYT-Chile, DTI-Universidad de Chile and Swedish Agency for Research in Developing Countries (SAREC). | es_CL |
Lenguage | dc.language.iso | en | es_CL |
Publisher | dc.publisher | Elsevier Science Ltd. | es_CL |
Keywords | dc.subject | Alkaloids | es_CL |
Título | dc.title | Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi | es_CL |
Document type | dc.type | Artículo de revista |
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