| Author | dc.contributor.author | Speisky Cosoy, Hernán | |
| Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
| Author | dc.contributor.author | Lissi Gervaso, Eduardo A. | es_CL |
| Author | dc.contributor.author | Videla Cabrera, Luis | es_CL |
| Admission date | dc.date.accessioned | 2012-11-12T19:41:19Z | |
| Available date | dc.date.available | 2012-11-12T19:41:19Z | |
| Publication date | dc.date.issued | 1990-11-30 | |
| Cita de ítem | dc.identifier.citation | Biochemical Pharmacology. Vol. 41, No. 11, pp. 1575-1581, 1991. | es_CL |
| Identifier | dc.identifier.issn | 0006-2952 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119591 | |
| Abstract | dc.description.abstract | Boldine, in low micromolar concentrations, was able to prevent brain bomogenate autooxidatíon,
the 2,2'·uobis(2·amidinopropane)(AAP)·induced Iipid peroxidation of red cell plasma
rnembranes, and the AAP·induced inactivation of Iysozyrne. These results are indicative of a bigh
reactivity of boldine towards free radicals. The anaJysis of the boldine effect as I function of incubation
times suggests that a rnetabolite resulting from the interaction of boldine with úee radicals also exhibits
antioxidant activity, being more efficient than boldine in brain homogenate luto-oxidation and leS5
efticient in Iysozyme protection uperiments. This behavior may,be Bccounted for in terms of the relalÍve
Jocation of the scavengers needed to afford maximal protection. | es_CL |
| Patrocinador | dc.description.sponsorship | This study was
supponed by grants from FONDECTY (987/1990), DICYT
(Universidad de Santiago de Chile) and DIUC (89004, E,
Universidad Católica de Chile). | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | Pergamon Press | es_CL |
| Título | dc.title | ANTIOXIDANT PROPERTIES OF THE ALKALOID BOLDINE IN SYSTEMS UNDERGOING LIPID PEROXIDATION AND ENZYME INACTlVATION | es_CL |
| Document type | dc.type | Artículo de revista | |
