Effects of Pluronic F68 Micellization on the Viability of Neuronal Cells in Culture
Author
dc.contributor.author
Samith, Vicente D.
Author
dc.contributor.author
Miño Galaz, Germán
es_CL
Author
dc.contributor.author
Ramos Moore, E.
es_CL
Author
dc.contributor.author
Arancibia Miranda, Nicolás
es_CL
Admission date
dc.date.accessioned
2014-01-08T17:15:06Z
Available date
dc.date.available
2014-01-08T17:15:06Z
Publication date
dc.date.issued
2013
Cita de ítem
dc.identifier.citation
J. APPL. POLYM. SCI. 2013
en_US
Identifier
dc.identifier.other
DOI: 10.1002/app.39426
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/119663
General note
dc.description
Artículo de publicación ISI
en_US
Abstract
dc.description.abstract
Triblock copolymers with surface-active properties, referred to as Pluronic, have shown potential medical applications
such as drug delivery to selective targets in the human body. In particular, the transport of anti-inflammatory substances to the brain
is required for illness treatment, thus the study of delivery agents that cross the blood–brain barrier is relevant. In this article we
study the effects of the micelle formation on the morphologic and cytotoxic properties of Pluronic F68. We determinate the critical
micellar concentration (CMC) by standard tensiometric and absorbance measurements, and also we analyze the morphology of polymers
by atomic force microscopy. Our observations indicate that the morphological properties of F68 are drastically modified in the
CMC range, as well as the ability to increase the viability of neuroblastoma cells maintained under culture conditions, as compared
with nontreated cells. Our conclusions highlight the close correlation between morphological and physiochemical properties of Pluronic,
which must be further understood in order to achieve highly controlled pharmacological uses. VC 2013 Wiley Periodicals, Inc. J. Appl.
Polym. Sci. 130: 2159–2164, 2013